Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Hot Off the Press
Skopelitou K, Muleta AW, Papageorgiou AC, Chronopoulou EG, Pavli O, Flemetakis E, Skaracis GN, Labrou NE. Int J Biol Macromol. 2016 Pubmed
Christophe Côme, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimente, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H. Busch, Markus W. Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4) e0152996. Link
Padzik A*, Deshpande P*, Hollos P*, Franker M, Rannikko EH, Cai D, Prus P, Mågård M, Westerlund N, Verhey KJ, James P, Hoogenraad CC, Coffey ET. KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons. Front Cell Neurosci. 2016 Mar 15;10:57. *equal contribution. Pubmed
MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers. Sami Ventelä, Juho-Antti Mäkelä, Rosalie Sears C, Jorma Toppari, Jukka Westermarck. Matters, Mar 03, 2016. Link
A K Najumudeen, A Jaiswal, B Lectez, C Oetken-Lindholm, C Guzmán, E Siljamäki, I MD Posada, E Lacey, T Aittokallio, D Abankwa. Cancer stem cell drugs target K-ras signaling in a stemness-context. Oncogene. 2016 Mar 14. [Epub ahead of print] Pubmed
Guzman C, Oetken-Lindholm C, Abankwa D. Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions. J Lab Autom 21(2):238-45 Pubmed
Ratcliffe CD*, Sahgal P*, Parachoniak CA, Ivaska J, Park M. * equal contribution. Regulation of cell migration and ß1 integrin trafficking by the endosomal adaptor GGA3. Traffic 2016 Mar 3 [Epub ahead of print] Pubmed
Mamaeva V, Niemi R, Beck M, Özliseli E, Desai D, Landor S, Gronroos T, Kronqvist P, Pettersen IK, McCormack E, Rosenholm JM, Linden M, Sahlgren C. Inhibiting Notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ- secretase inhibitors. Mol Ther. 2016 Feb 26. [Epub ahead of print]. Pubmed
Najumudeen AK, Posada IM, Lectez B, Zhou Y, Landor SK, Fallarero A, Vuorela P, Hancock J, Abankwa D. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. Biochemistry. 2015 Dec 15;54(49):7212-21. Pubmed
Guzmán C, Oetken-Lindholm C, Abankwa D. Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions. J Lab Autom. 2015 Sep 17. Pubmed
Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzmán C, Härmä H, Hancock JF, Aittokallio T, Abankwa D. Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation. Elife. 2015 Aug 14;4:e08905. Pubmed
Hyötyläinen T, Jerby L, Petäjä EM, Mattila I, Jäntti S, Auvinen P, Gastaldelli A, Yki-Järvinen H, Ruppin E & Orešič M. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Nature Communications 7: 8994 (2016). Pubmed.
Rosenholm JM, Gulin-Sarfraz T, Mamaeva V, Niemi R, Özliseli E, Desai D, Antfolk D, von Haartman E, Lindberg D, Prabhakar N, Näreoja T, Sahlgren C. Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo. Small. 2016 Jan 25. [Epub ahead of print] Pubmed
Desai D, Prabhakar N, Mamaeva V, Şen Karaman D, Lähdeniemi IAK, Sahlgren C, Rosenholm JM, Toivola DM. Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles. International Journal of Nanomedicine, 2016:11, 299—313. Link
Paramonov VM, Mamaeva V, Sahlgren C, Rivero-Müller A. Genetically-encoded tools for cAMP probing and modulation in living systems. Front Pharmacol. Online 2015 Sep 15. Pubmed
Rosenholm JM, Zhang J, Linden M, Sahlgren C. Mesoporous silica nanoparticles in tissue engineering - a perspective. Nanomedicine (Lond). 2016 Jan 19. [Epub ahead of print] Pubmed
Nicola De Franceschi, Antti Arjonen, Nadia Elkhatib, Konstantin Denessiouk, Antoni G Wrobel, Thomas A Wilson, Jeroen Pouwels, Guillaume Montagnac, David J Owen and Johanna Ivaska. Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nature Structural & Molecular Biology, 18 January 2016. Advance online publication
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
Hasan Mohammad, Åbo Akademi University, 6th of April, 2016: JNK regulation of neurogenesis, neuroplasticity and anxiety-related behaviors in mice.
Nicola De Franceschi, University of Turku, 12th of February 2016: Integrin cytoplasmic tail interactors: the insiders' game.
Arafath Kaja Najumudeen, Åbo Akademi University, 15th of January 2016: Targeting oncogenic signaling proteins - new insights using a FRET-based chemical biology approach
Asta Laiho, University of Turku, 9th of January 2016: Data analysis tools and methods for DNA microarray and high-throughput sequencing data
Sini Junttila, University of Turku, 8th of January 2016: Characterisation of Cladonia rangiferina transcriptome and genome, and the effects of dehydration and rehydration on its gene expression.
Pekka Heikkinen, University of Turku, 11th of December 2015: Modulation of TGF-β signaling by Hypoxia
Reetta Virtakoivu, University of Turku, 4th of December 2015: From epithelial to mesenchymal: regulation of invasive cancer cell motility From epithelial to mesenchymal: regulation of invasive cancer cell motility
Marika Sjöqvist, Åbo Akademi University, 13th of October 2015: Networking Notch : regulation of Notch traffic and signaling crosstalk
Mirkka Heinonen, University of Turku, 15th of September 2015: Players of Th-cell differentiation and immune dysregulation - focus on GIMAP family genes
Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis
Emilia Komulainen, Åbo Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks
Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation
Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain
Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification
Zhi Jane Chen:
Signal transduction pathways and transcriptional regulation in the control of Th17 cell differentiation
Wednesday, May 4 at 11:15
PharmaCity Auditorium, ItÃ¤inen PitkÃ¤katu 4, Turku
New Research Opportunities Opened by Optogenetic Technologies
Monday, May 9 at 15:00
PET Centre seminar room 1st floor (Kiinamyllynkatu 4-8, building #14)
43rd Annual meeting of the Scandinavian Society of Immunology and Summer School
Tuesday, May 10 at 9:00 - Monday, June 13 at 14:00
Radisson Blu Marina Palace Hotel, Linnankatu 32