Hot Off the Press

Skopelitou K, Muleta AW, Papageorgiou AC, Chronopoulou EG, Pavli O, Flemetakis E, Skaracis GN, Labrou NE. Int J Biol Macromol. 2016 Pubmed

Christophe Côme, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimente, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H. Busch, Markus W. Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4) e0152996. Link

Padzik A*, Deshpande P*, Hollos P*, Franker M, Rannikko EH, Cai D, Prus P, Mågård M, Westerlund N, Verhey KJ, James P, Hoogenraad CC, Coffey ET. KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons.  Front Cell Neurosci. 2016 Mar 15;10:57. *equal contribution. Pubmed

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers. Sami Ventelä, Juho-Antti Mäkelä, Rosalie Sears C, Jorma Toppari, Jukka Westermarck. Matters, Mar 03, 2016. Link

A K Najumudeen, A Jaiswal, B Lectez, C Oetken-Lindholm, C Guzmán, E Siljamäki, I MD Posada, E Lacey, T Aittokallio, D Abankwa. Cancer stem cell drugs target K-ras signaling in a stemness-context. Oncogene. 2016 Mar 14. [Epub ahead of print] Pubmed

Guzman C, Oetken-Lindholm C, Abankwa D. Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions. J Lab Autom 21(2):238-45 Pubmed

Ratcliffe CD*, Sahgal P*, Parachoniak CA, Ivaska J, Park M. * equal contribution. Regulation of cell migration and ß1 integrin trafficking by the endosomal adaptor GGA3. Traffic 2016 Mar 3 [Epub ahead of print] Pubmed

Mamaeva V, Niemi R, Beck M, Özliseli E, Desai D, Landor S, Gronroos T, Kronqvist P, Pettersen IK, McCormack E, Rosenholm JM, Linden M, Sahlgren C. Inhibiting Notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ- secretase inhibitors. Mol Ther. 2016 Feb 26. [Epub ahead of print]. Pubmed

Najumudeen AK, Posada IM, Lectez B, Zhou Y, Landor SK, Fallarero A, Vuorela P, Hancock J, Abankwa D. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. Biochemistry. 2015 Dec 15;54(49):7212-21. Pubmed

Guzmán C, Oetken-Lindholm C, Abankwa D. Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions. J Lab Autom. 2015 Sep 17. Pubmed

Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzmán C, Härmä H, Hancock JF, Aittokallio T, Abankwa D. Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation. Elife. 2015 Aug 14;4:e08905. Pubmed

Hyötyläinen T, Jerby L, Petäjä EM, Mattila I, Jäntti S, Auvinen P, Gastaldelli A, Yki-Järvinen H, Ruppin E & Orešič M. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Nature Communications 7: 8994 (2016). Pubmed.

Rosenholm JM, Gulin-Sarfraz T, Mamaeva V, Niemi R, Özliseli E, Desai D, Antfolk D, von Haartman E, Lindberg D, Prabhakar N, Näreoja T, Sahlgren C. Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo. Small. 2016 Jan 25. [Epub ahead of print] Pubmed

Desai D, Prabhakar N, Mamaeva V, Şen Karaman D, Lähdeniemi IAK, Sahlgren C, Rosenholm JM, Toivola DM. Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles. International Journal of Nanomedicine, 2016:11, 299—313. Link

Paramonov VM, Mamaeva V, Sahlgren C, Rivero-Müller A. Genetically-encoded tools for cAMP probing and modulation in living systems. Front Pharmacol. Online 2015 Sep 15. Pubmed

Rosenholm JM, Zhang J, Linden M, Sahlgren C. Mesoporous silica nanoparticles in tissue engineering - a perspective. Nanomedicine (Lond). 2016 Jan 19. [Epub ahead of print] Pubmed

Nicola De Franceschi, Antti Arjonen, Nadia Elkhatib, Konstantin Denessiouk, Antoni G Wrobel, Thomas A Wilson, Jeroen Pouwels, Guillaume Montagnac, David J Owen and Johanna Ivaska. Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nature Structural & Molecular Biology, 18 January 2016. Advance online publication

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Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!

Some of Our Recently Awarded PhDs

Hasan Mohammad, Åbo Akademi University, 6th of April, 2016: JNK regulation of neurogenesis, neuroplasticity and anxiety-related behaviors in mice.

Nicola De Franceschi,  University of Turku, 12th of February 2016: Integrin cytoplasmic tail interactors: the insiders' game.  

Arafath Kaja Najumudeen, Åbo Akademi University, 15th of January 2016: Targeting oncogenic signaling proteins - new insights using a FRET-based chemical biology approach

Asta Laiho, University of Turku, 9th of January 2016: Data analysis tools and methods for DNA microarray and high-throughput sequencing data

Sini Junttila, University of Turku, 8th of January 2016: Characterisation of Cladonia rangiferina transcriptome and genome, and the effects of dehydration and rehydration on its gene expression.

Pekka Heikkinen, University of Turku, 11th of December 2015: Modulation of TGF-β signaling by Hypoxia

Reetta Virtakoivu, University of Turku, 4th of December 2015: From epithelial to mesenchymal: regulation of invasive cancer cell motility From epithelial to mesenchymal: regulation of invasive cancer cell motility

Marika Sjöqvist, Åbo Akademi University, 13th of October 2015: Networking Notch : regulation of Notch traffic and signaling crosstalk

Mirkka Heinonen,  University of Turku, 15th of September 2015:  Players of Th-cell differentiation and immune dysregulation - focus on GIMAP family  genes

Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis

Emilia Komulainen, Åbo  Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks

Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation

Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain

Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification


MIKRO Seminars of Infection Biology and Infectious Diseases

Zhi Jane Chen:
Signal transduction pathways and transcriptional regulation in the control of Th17 cell differentiation
Wednesday, May 4 at 11:15
PharmaCity Auditorium, Itäinen Pitkäkatu 4, Turku

PET seminar

Michael Courtney:
New Research Opportunities Opened by Optogenetic Technologies
Monday, May 9 at 15:00
PET Centre seminar room 1st floor (Kiinamyllynkatu 4-8, building #14)


Several speakers:
43rd Annual meeting of the Scandinavian Society of Immunology and Summer School
Tuesday, May 10 at 9:00 - Monday, June 13 at 14:00
Radisson Blu Marina Palace Hotel, Linnankatu 32

New Personnel

Dickens Alex

Postdoctoral Fellow
Oresic Matej - Systems Medicine

Shetty Ankitha

Graduate Student
Lahesmaa Riitta - Molecular Immunology

Laporte Sophie

Papageorgiou Tassos - Protein Crystallography

Rytkönen Kalle

Postdoctoral Fellow
Elo Laura - Computational Biomedicine

Merisaari Joni

Graduate Student
Westermarck Jukka - Cancer Cell Signaling

Sharma Mukund

Graduate Student
Abankwa Daniel - GTPases Mechanisms