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Chronopoulou EG, Papageorgiou AC, Markoglou A, Labrou NE. Inhibition of human glutathione transferases by pesticides: Development of a simple analytical assay for the quantification of pesticides in water. J. Mol. Catal. B (2012) DOI

Tuomela S, Salo V, Tripathi SK, Chen Z, Laurila K, Gupta B, Äijö T, Oikari L, Stockinger B, Lähdesmäki H and Lahesmaa R. Identification of early gene expression changes during human Th17 cell differentiation. Blood [Epub ahead of print] Pubmed

Skopelitou K, Dhavala P, Papageorgiou AC, Labrou NE. A glutathione transferase from Agrobacterium tumefaciens reveals a novel class of bacterial GST superfamily. PLoS One. 2012; 7(4): e34263 Pubmed

Niemelä M, Kauko O, Sihto H, Mpindi J-P, Nicorici D, Pernilä P, Kallioniemi O-P, Joensuu H, Hautaniemi S, and Westermarck J. CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes. Oncogene, [Epub ahead of print], 2012. Pubmed

Ventelä S, Mäkelä J-A, Kulmala J, Westermarck J, and Toppari J. Identification and regulation of a stage-specific stem cell niche enriched by Nanog positive spermatogonial stem cells in the mouse testis. STEM CELLS, in press, 2012. Pubmed

Ventelä S, Come C, Mäkelä J-A, Hobbs RM, Mannermaa L, Kallajoki M, Chan EK, Pandolfi PP, Toppari J, and Westermarck J; CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice. PLoS ONE, 7(3), e33209, 2012. Pubmed

Elo LL, Kallio A, Laajala TD, Hawkins RD, Korpelainen E, Aittokallio T. Optimized detection of transcription factor binding sites in ChIP-seq experiments. Nucleic Acids Res. 40(1): e1, 2012. Pubmed

Elo LL, Schwikowski B. Mining proteomic data for biomedical research. Invited review in WIREs Data Mining Knowl. Discov. 2(1): 1-13, 2012.

Korhonen JT, Puolakkainen M, Häivälä R, Penttilä T, Haveri A, Markkula E, Lahesmaa R. Flotillin-1/reggie-2 contributes to Chlamydia pneumoniae growth and associates with bacterial inclusion. Infect Immun. 2012 Jan 3. [Epub ahead of print] Pubmed

Korhonen JT, Puolakkainen M, Haveri A, Tammiruusu A, Sarvas M, Lahesmaa R. Chlamydia pneumoniae entry into epithelial cells by clathrin-independent endocytosis. Microb Pathog. 2011 Dec 21. [Epub ahead of print] Pubmed

Rosenholm JM, Mamaeva V, Sahlgren C, Lindén M. Nanoparticles in targeted cancer therapy: mesoporous silica nanoparticles entering preclinical development stage. Nanomedicine (Lond). 2012 Jan;7(1):111-20. Pubmed

Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R. RNA Binding Protein L1TD1 Interacts with LIN28 via RNA and is Required for Human Embryonic Stem Cell Self-Renewal and Cancer Cell Proliferation. Stem Cells. 2011 Dec 12. doi: 10.1002/stem.1013. [Epub ahead of print] Pubmed

Li DC, Li AN, Papageorgiou AC. Cellulases from thermophilic fungi: recent insights and biotechnological potential. Enzyme Res. 2011;2011:308730. Pubmed

Vähämaa H, Koskinen VR, Hosia W, Moulder R, Nevalainen OS, Lahesmaa R, Aittokallio T, Salmi J. PolyAlign: A Versatile LC-MS Data Alignment Tool for Landmark-Selected and -Automated Use. Int J Proteomics. 2011;2011:450290. Epub 2011 Apr 19. Pubmed

Landor SK, Mutvei AP, Mamaeva V, Jin S, Busk M, Borra R, Grönroos TJ, Kronqvist P, Lendahl U, Sahlgren CM. Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms. Proc Natl Acad Sci U S A. 2011 Nov 7. [Epub ahead of print]. Pubmed

Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Mattila E, Potter CS, Duffy T, Sundberg JP, Kallioniemi O, Askari JA, Humphries MJ, Parsons M, Salmi M, Ivaska J. SHARPIN is an endogenous inhibitor of β-integrin activation. Nat. Cell. Biol. [Epub ahead of print] Pubmed

Tripathi P, Sahoo N, Ullah U, Kallionpää H, Suneja A, Lahesmaa R, Rao KVS. MAP kinase initiates digital regimes of signal sensing to control specificity and
amplitude of human Th2 cell differentiation. Immunol Cell Biol. 2011 Oct 11. doi: 10.1038/icb.2011.87. [Epub ahead of print]

Skopelitou K, Muleta AW, Pavli O, Skaracis GN, Flemetakis E, Papageorgiou AC, Labrou NE. Overlapping protective roles for gluta- thione transferase gene family members in chemical and oxidative stress response in Agrobacterium tumefaciens. Funct Integr Genomics. 2011 Sep 10. Pubmed

Mai, A., Veltel, S., Pellinen, T., Padzik, A., Coffey, E., Marjomäki, V. and Ivaska, J. (2011) Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor trafficking in migrating cancer cells. J. Cell Biol. 194:291-306. Pubmed

Ivaska J. and Heino J (2011) Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis. Annu. Rev. Cell Dev. Biol. Jun 10. [Epub ahead of print]. Pubmed

Mamaeva V, Rosenholm JM, Bate-Eya LT, Bergman L, Peuhu E, Duchanoy A, Fortelius LE, Landor S, Toivola DM, Lindén M, Sahlgren C. Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer. Mol Ther. 2011 May 31. [Epub ahead of print] Pubmed

Rosenholm JM, Sahlgren C, Lindén M. Multifunctional Mesoporous Silica Nanoparticles for Combined Therapeutic, Diagnostic and Targeted Action in Cancer Treatment. Curr. Drug Targets 2011 Mar 28. Pubmed

Haikarainen T, Thanassoulas A, Stavros P, Nounesis G, Haataja S, Papageorgiou AC. Structural and thermodynamic characterization of metal ion binding in Streptococcus suis Dpr. 2011 J Mol Biol. 405(2):448-60. Pubmed

Haikarainen T, Paturi P, Lindén J, Haataja S, Meyer-Klaucke W, Finne J, Papageorgiou AC. Magnetic properties and structural characterization of iron oxide nanoparticles formed by Streptococcus suis Dpr and four mutants. 2011 J Biol Inorg Chem. 2011 Apr 13. Pubmed

Leivonen SK, Rokka A, Ostling P, Kohonen P, Corthals GL, Kallioniemi O, Perälä M. Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact. Mol. Cell Proteomics. 2011 April 21. Pubmed

Rodrigues AJ, Neves-Carvalho A, Teixeira-Castro A, Rokka A, Corthals G, Logarinho E, Maciel P. Absence of Ataxin-3 Leads to Enhanced Stress Response in C. elegans. PLoS One. 2011 April 19;6(4):e18512. Pubmed

Kouvonen P, Rainio EM, Suni V, Koskinen P, Corthals GL. Enrichment and sequencing of phosphopeptides using indium tin oxide coated glass slides. Mol. Biosyst. 2011 April 27. Pubmed

O'Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y. Genomic views of STAT function in CD4(+) T helper cell differentiation. Nat Rev Immunol. 2011 Apr; 11(4):239-50. Pubmed

Hussein S.M., Batada N.N., Vuoristo S , Ching R.W. , Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M,Oliver Brüstle, Bazett-Jones D.P. , Alitalo K, Lahesmaa R , Nagy A & Otonkoski T, Copy number variation and selection during reprogramming to pluripotency, Nature (2011) 471:58-62. Published on-line 3.3.2011.

Westerlund N, Zdrojewska J, Padzik A, Komulainen E, Björkblom B, Rannikko E, Tararuk T, Garcia-Frigola C, Sandholm J, Nguyen L, Kallunki T, Courtney MJ, Coffey ET. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate.Nat Neurosci. February 6th, 2011. Pubmed

Koh KP, Yabuuchi A, Rao S, Cunniff K, Laiho A, Tahiliani M, Huang Y, Thompson E, Nardone J, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A., Tet1 and related 5-methylcytosine hydroxylases modulate pluripotency and cell lineage specification in mouse embryonic stem cells. (2011) Cell Stem Cell, 8, 200-213.

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News

Watch interview with Systems Biologist Leroy Hood
Watch the video - click the green button 'katso video': http://www.ts.fi/uutiset/kotimaa/333098/Laaketieteen+

Turkulaiselle syöpätutkimukselle yli miljoonan euron rahoitus
Sigrid Juséliuksen säätiö myönsi apurahoja lääketieteelliseen tutkimukseen. Turun yliopiston syöpäbiologian professori Jukka Westermarckin tutkimukseen myönnettiin viisivuotinen apuraha, jonka kokonaissumma nousee 1,25 miljoonaan euroon.

A new protein required for human embryonic stem cell renewal discovered
A research group lead by Professor Riitta Lahesmaa at Turku Centre for Biotechnology has discovered a new protein L1TD1 exploiting genome wide transcriptomics. This RNA binding protein is highly expressed by human embryonic stem cells (hESC) and is required for their renewal.

Ihmisen alkion kantasoluille välttämätön proteiini löytyi
Turkulainen tutkimusryhmä on löytänyt ihmisen alkion kantasoluille välttämättömän uuden proteiinin. Professori Riitta Lahesmaan ryhmä Turun Biotekniikan keskuksessa löysi uuden proteiinin nimeltä L1TD1 ihmisen genomin kattavalla geenien ilmenemistä mittaavilla DNA-mikrosiruilla.

A Warburg challenge
A study led by Academy Research Fellow Cecilia Sahlgren shifts the Warburg paradigm on cancer cell metabolism. The metabolic phenotype of cancer cells described by Nobel laureate Otto Warburg in the 1930s has considerably influenced the cancer research field and therapeutic approaches. Metabolic reprogramming in cancer is characterized by an increase in glycolysis over oxidative phosphorylation - the Warburg effect. The study by Landor et al. PNAS 2011 challenges the link between glycolysis and cancer progression and demonstrates that metabolic flexibility rather than increased glycolysis drives aggressive cancer growth.

Researchers from professor Johanna Ivaska's group at CBT have found SHARPIN
Researchers from professor Johanna Ivaska's group at CBT have found SHARPIN, a novel ubiquitiously expressed inhibitor of integrin activity, using HTS RNAi screening. There paper published in Nature Cell Biology November 2011 demonstrates that SHARPIN regulates integrin activity in vitro and in vivo in many different cells types. Mice lacking SHARPIN display a complex phenotype and have abnormally elevated integrin activity in their epidermis and leukocytes. Thus Sharpin is a critical molecule involved in switching integrins to inactive forms.

Professor Johanna Ivaska is awarded the Anders Jahre Prize for Young Scientists
Professor Johanna Ivaska from VTT and University of Turku is awarded an esteemed Nordic prize for medical research in 2011, the Anders Jahre Prize for Young Scientists. She shares the prize of 400,000 NOK with Professor Søren Paludan, University of Aarhus.

New Centre of Excellence resolving connections between immune system and inflammatory diseases
The Finnish Academy chose Molecular Systems Immunology and Physiology Research Group as one of its new Centres of Excellence for the period of 2012 – 2017. Solving the mechanisms how type 1 diabetes develops is one of the main focuses of the venture.

The SYBILLA project in FP7 of the EU
The SYBILLA project - “Systems Biology of T-cell activation in health and disease” - is a multidisciplinary consortium of 17 scientific and industrial partners that is funded by the European Union for 5 years. Its goal is to understand at the systems level, how T-cells discriminate foreign from autoantigens by activating quantitatively distinct signalling pathways. Applying a systems biology approach, based on new transcriptomic, proteomic and biochemical technologies, SYBILLA investigates complex molecular networks with unprecedented precision. Progress during the first 2.5 years has allowed to discover new mechanisms of how T cells distinguish self from foreign antigens and how the TCR becomes activated upon antigen-binding. Novel proteins and mRNAs have been identified that play a role in T cell activation and differentiation. Further large scale proteomics and transcriptomics studies are in progress. One of the goals is to generate a “virtual T-cell” that enables prediction of physiological and pathophysiological cellular response and aids in the design of new therapeutical approaches. Further information; http://www.sybilla-t-cell.de/ and http://www.btk.fi/research/research-groups/lahesmaa-riitta-molecular-immunology/

Researchers have shed new light on how brain cells control their movement to form the cerebral cortex.
Incorrect placement of neurons during brain development may leave us at risk of diseases and conditions ranging from epilepsy and mental retardation to schizophrenia and dyslexia. If a neuron moves too fast during this journey, it may not take the correct route or reach its destination. The way neurons control their speed of migration has not been clear. This study, led by Academy Research Fellow Eleanor Coffey at Turku Centre for Biotechnology, identifies new players that put the brakes on. They show in mice that lack the star player "JNK1", newborn neurons spend much less time in the multipolar stage, which is when the cells prepare for subsequent expedition, possibly choosing the route to be taken. Having hurried through this stage, they move off at high speed to reach their final destinations in the cortex days earlier and less precisely than in a normal mouse. The results of their study are published in the latest issue of Nature Neuroscience.

Researchers have found how brain cells control their movement to form the cerebral cortex
A study led by Academy Research Fellow Eleanor Coffey identifies new players that put the brakes on. They show in mice that lack the star player "JNK1", that newborn neurons spend less time in the multipolar stage, which is when the cells prepare for subsequent expedition, possibly choosing the route to be taken. Having hurried through this stage, they move off at high speed to reach their final destinations in the cortex days earlier and less precisely than in a normal mouse. The results of their study are published in the latest issue of Nature Neuroscience.

Proteiinit ja syöpä – suomalaistutkijoiden työ etenee (05.01.2011)
Pari vuotta sitten suomalaiset syöpätutkijat tekivät mullistavan löydön. Syövän syntyyn vaikuttaa proteiini, joka häiritsee solun kasvua hillitsevien proteiinien toimintaa. Siten se vauhdittaa solun kasvua syöpäsoluksi. Tutkimus etenee ja tuon CIP2A-proteiinin touhuista ja esiintymisestä tiedetään huomattavasti enemmän.