Publications

Hot Off the Press

Hrdlickova B, Kumar V, Kanduri K, Zhernakova DV, Tripathi S, Karjalainen J, Lund RJ, Li Y, Ullah U, Modderman R, Abdulahad W, Lähdesmäki H, Franke L, Lahesmaa R, Wijmenga C, Withoff S. Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity. Genome Medicine. 2014, 6:88. Pubmed

Trehan A, Rotgers E, Coffey ET, Huhtaniemi I, Rivero-Müller A. CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures. Cell Commun Signal. 2014 Nov 4;12(1):70. Pubmed

Komulainen E, Zdrojewska J, Freemantle E, Mohammad H, Kulesskaya N, Deshpande P, Marchisella F, Mysore R, Hollos P, Michelsen KA, Mågard M, Rauvala H, James P, Coffey ET. JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination. Front Cell Neurosci. 2014 Sep 12;8:272. Pubmed

Heinonen MT, Kanduri K, Lähdesmäki HJ, Lahesmaa R, Henttinen TA. Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation. Immunol Cell Biol. 2014 Oct 7. doi: 10.1038/icb.2014.86. Pubmed

Kallionpää H, Laajala E, Oling V, Härkönen T, Tillmann V, Dorshakova NV, Ilonen J, Lähdesmäki H, Knip M, Lahesmaa R; DIABIMMUNE Study Group; DIABIMMUNE Study Group. Standard of hygiene and immune adaptation in newborn infants. Clin Immunol. 2014 Sep 22;155(1):136-147. Pubmed

Kumar V, Gutierrez-Achury J, Kanduri K, Almeida R, Hrdlickova B, Zhernakova DV, Westra HJ, Karjalainen J, Ricaño-Ponce I, Li Y, Stachurska A, Tigchelaar EF, Abdulahad WH, Lähdesmäki H, Hofker MH, Zhernakova A, Franke L, Lahesmaa R, Wijmenga C, Withoff S. Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels. Hum Mol Genet. 2014 Sep 4. pii: ddu453. [Epub ahead of print] Pubmed

Elsing AN, Aspelin C*, Björk JK*, Bergman HA, Himanen SV, Kallio MJ, Roos-Mattjus P, Sistonen L (2014) Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. J. Cell. Biol., 206, 735-749. *equal contribution Pubmed

Tripathi SK, Lahesmaa R. Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev. 2014 Sep;261(1):62-83. Pubmed

Kyläniemi MK, Kaukonen R, Myllyviita J, Rasool O, Lahesmaa R. The Regulation and Role of c-FLIP in Human Th Cell Differentiation. PLoS One. 2014 Jul 14;9(7):e102022. Pubmed

van Montfrans J, Zavialov A, Zhou Q. Mutant ADA2 in Vasculopathies. N Engl J Med. 2014 Jul 31;371(5):478-481. Pubmed

Äijö T, Butty V, Chen Z, Salo V, Tripathi S, Burge CB, Lahesmaa R, Lähdesmäki H. Methods for time series analysis of RNA-seq data with application to human Th17 cell differentiation. Bioinformatics. 2014 Jun 15;30(12):i113-i120. Pubmed

Kelkka T, Kienhoefer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R. Reactive oxygen species deficiency induces autoimmunity with downstream interferon signature. Antioxid Redox Signal. 2014 Apr 30. [Epub ahead of print] Pubmed

Coffey, E. Nuclear and cytosolic JNK signalling in neurons. Nat. Rev. Neurosci. 2014 Apr 17;15(5):285-99. Pubmed

Laine A, Westermarck J. Molecular Pathways: Harnessing E2F1 Regulation for Prosenescence Therapy in p53 Defective Cancer Cells. Clin Cancer Res. 2014 May 1. [Epub ahead of print] Pubmed

Guzmán C, Solman M, Abankwa D. Nanoclustering and heterogeneous membrane diffusion of Ras studied by FRAP and RICS analysis. Methods Mol Biol. 2014;1120:307-26. Pubmed

Papageorgiou AC & Mattsson J. Protein structure validation and analysis with x-ray crystallography. Methods Mol Biol. 2014; 1129:397-421. Pubmed

Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C. PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res. 2014 Mar 25 [Epub ahead of print]. Pubmed

Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol. 2014 Apr;15(4):384-92. Pubmed

Hämäläinen S, Nurminen N, Ahlfors H, Oikarinen S, Sioofy-Khojine AB, Frisk G,
Oberste MS, Lahesmaa R, Pesu M, Hyöty H. Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity. J Med Virol. 2014 Feb 20. [Epub ahead of print] Pubmed

Munukka E, Pekkala S, Wiklund P, Rasool O, Borra R, Kong L, Ojanen X, Cheng SM, Roos C, Tuomela S, Alen M, Lahesmaa R, Cheng S. Gut-adipose tissue axis in hepatic fat accumulation in humans. J Hepatol. 2014 Mar 5. pii: S0168-8278(14)00128-7. [Epub ahead of print] Pubmed

Noisa P, Lund C, Kanduri K, Lund R, Lähdesmäki H, Lahesmaa R, Lundin K,
Chokechuwattanalert H, Otonkoski T, Tuuri T, Raivio T. Notch signaling regulates neural crest differentiation from human pluripotent
stem cells. J Cell Sci. 2014 Feb 25. [Epub ahead of print] Pubmed

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Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!

News

Miljoonarahoitus aivosyövän uuden hoitostrategian kehittämiseen
Jane ja Aatos Erkon Säätiö on myöntänyt lähes miljoonan euron rahoituksen Turun ja Helsingin yliopistojen yhteiselle tutkijaryhmälle, joka pyrkii ratkaisemaan aivosyövän hoidon haasteita. Onnistuessaan hanke loisi mahdollisuudet merkittäviin läpimurtoihin syöpähoidoissa. Työryhmän johtaja Turun yliopiston professori Jukka Westermarck on yksi johtavista tämän tyyppisten syöpään vaikuttavien mekanismien tutkijoista. Westermarck työskentelee Turun Biotekniikan keskuksessa.

Johanna Ivaskasta Akatemiaprofessori
Suomen Akatemia myönsi viisivuotisen akatemiaprofessuurin molekulaarisen solubiologian professori Johanna Ivaskalle.

Recently Awarded PhDs

http://www.doria.fi/handle/10024/96595

Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain

Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification

Tomoko Asaoka, Åbo Akademi University, 13th of December 2013: Regulation of cell fate by c-FLIP phosphorylation

Minna Kyläniemi, University of Turku, 4th of October 2013:
Regulation of lymphocyte response in vitro and in vivo

Nelly Rahkonen, University of Turku, 13th of September 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells

Saima Ferraris, Åbo Akademi University, 13th of August 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation

Anni Laine, University of Turku, 14th of June 2013, The role of an oncoprotein CIP2A in breast cancer.

Antti Arjonen, University of Turku, 14th of June 2013, Integrins on the move.

Soile Tuomela,  University of Turku, 26th of April 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.

Mari Björkman, University of Turku, 1st of March 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Therapeutic Development

Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics

Gunilla Högnäs, University of Turku, 8th of February 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion

Tapio Lönnberg, University of Turku, 26th of October 2012:
System-wide approaches to uncover Th2 cell lineage commitment

Elisa Närvä, University of Turku, 19th of October 2012:
Pluripotency and genetic stability of human pluripotent stem cells

Krista Rantanen, University of Turku, 12th of October 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival

 

Events

Frontiers of Science Seminar

Prof. Anne Cooke:
Factors governing onset of Type 1 diabetes
Thursday, November 27 at 12:00
Mauno Conference Center, President auditorium, BioCity, Turku

Turku Centre for Systems Biology Seminar

Matti Nykter:
Chromatin organization in prostate cancer progression
Tuesday, December 2 at 12:15
PharmaCity Auditorium, Itäinen Pitkäkatu 4 B, Turku

MIKRO Seminars of Infection Biology and Infectious Diseases

Jukka Hytönen:
Lyme borreliosis: Susceptibility, pathogenesis and diagnostics
Wednesday, December 3 at 11:15
Auditorium of Mikro, Kiinamyllynkatu 13

Careers

Project researcher position

in Riitta Lahesmaa's research group to work on type 1 diabetes. The position must be applied by the 8th of December, 2014 using the electronic system.

New Personnel

Hong Ye

Graduate Student
 
Group:
Coffey Eleanor - Kinase Function in Brain

Garcia Munoz Virginia

Exchange Student
 
Group:
Coffey Eleanor - Kinase Function in Brain

Laurén Lassi

Under Graduate
 
Group:
Coffey Eleanor - Kinase Function in Brain