Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Hot Off the Press
Najumudeen AK, Posada IM, Lectez B, Zhou Y, Landor SK, Fallarero A, Vuorela P, Hancock J, Abankwa D. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. Biochemistry. 2015 Dec 15;54(49):7212-21. Pubmed
Guzmán C, Oetken-Lindholm C, Abankwa D. Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions. J Lab Autom. 2015 Sep 17. Pubmed
Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzmán C, Härmä H, Hancock JF, Aittokallio T, Abankwa D. Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation. Elife. 2015 Aug 14;4:e08905. Pubmed
Hyötyläinen T, Jerby L, Petäjä EM, Mattila I, Jäntti S, Auvinen P, Gastaldelli A, Yki-Järvinen H, Ruppin E & Orešič M. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Nature Communications 7: 8994 (2016). Pubmed.
Rosenholm JM, Gulin-Sarfraz T, Mamaeva V, Niemi R, Özliseli E, Desai D, Antfolk D, von Haartman E, Lindberg D, Prabhakar N, Näreoja T, Sahlgren C. Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo. Small. 2016 Jan 25. [Epub ahead of print] Pubmed
Desai D, Prabhakar N, Mamaeva V, Şen Karaman D, Lähdeniemi IAK, Sahlgren C, Rosenholm JM, Toivola DM. Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles. International Journal of Nanomedicine, 2016:11, 299—313. Link
Paramonov VM, Mamaeva V, Sahlgren C, Rivero-Müller A. Genetically-encoded tools for cAMP probing and modulation in living systems. Front Pharmacol. Online 2015 Sep 15. Pubmed
Rosenholm JM, Zhang J, Linden M, Sahlgren C. Mesoporous silica nanoparticles in tissue engineering - a perspective. Nanomedicine (Lond). 2016 Jan 19. [Epub ahead of print] Pubmed
Nicola De Franceschi, Antti Arjonen, Nadia Elkhatib, Konstantin Denessiouk, Antoni G Wrobel, Thomas A Wilson, Jeroen Pouwels, Guillaume Montagnac, David J Owen and Johanna Ivaska. Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nature Structural & Molecular Biology, 18 January 2016. Advance online publication
Axarli I, Muleta AW, Vlachakis D, Kossida S, Kotzia G, Maltezos A, Dhavala P, Papageorgiou AC, Labrou NE. Directed Evolution of Tau Class Glutathione Transferases Reveals A Site That Regulates Catalytic Efficiency And Masks Cooperativity. Biochem J. 2015. Pubmed
Kartiek Kanduri, Subhash Tripathi, Antti Larjo, Henrik Mannerström, Ubaid Ullah, Riikka Lund, R. David Hawkins, Bing Ren, Harri Lähdesmäki and Riitta Lahesmaa. Identification of global regulators of T-helper cell lineage specification. Genome Medicine. 2015, 7:122 Pubmed
Ortega-Martínez S. A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis. Front Mol Neurosci. 2015 August. Pubmed
Yuba Raj Pokharel, Jani Saarela, Agnieszka Szwajda, Christian Rupp, Anne Rokka, Shibendra Kumar Lal Karna, Kaisa Teittinen, Garry Corthals, Olli Kallioniemi, Krister Wennerberg, Tero Aittokallio and Jukka Westermarck. Relevance Rank Platform (RRP) for functional filtering of high content protein-protein interaction data. Molecular and Cellular Proteomics October 2015, 14 (10). Abstract
Jonna Alanko, Anja Mai, Guillaume Jacquemet, Kristine Schauer, Riina Kaukonen, Markku Saari, Bruno Goud and Johanna Ivaska. Integrin endosomal signalling suppresses anoikis. Nature Cell Biology. Published online 05 October 2015. Pubmed
Routila J, Bilgen T, Saramäki O, Grénman R, Visakorpi T, Westermarck J, Ventelä S. Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma. J Oral Pathol Med. 2015 Oct 5. [Epub ahead of print] Pubmed
Suomi T, Corthals GL, Nevalainen OS, Elo LL. Using peptide-level proteomics data for detecting differentially expressed proteins. J Proteome Res. 2015 Sep 29. Pubmed
Routila J, Mäkelä JA, Luukkaa H, Leivo I, Irjala H, Westermarck J, Mäkitie A, Ventelä S, Potential role for inhibition of protein phosphatase 2A tumor suppressor in salivary gland malignancies. Genes Chromosomes Cancer. [Epub ahead of print] Pubmed
Kaur A, Elzagheid A, Birkman EM, Avoranta T, Kytölä V, Korkeila E, Syrjänen K, Westermarck J, Sundström J. Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer. Cancer Med. 2015 Sep 17. [Epub ahead of print] Pubmed
Fatemeh Seyednasrollah, Krista Rantanen, Panu Jaakkola and Laura L. Elo. ROTS: reproducible RNA-seq biomarker detector—prognostic markers for clear cell renal cell cancer. Nucl. Acids Res. August 11, 2015 Abstract
Kauko O, Laajala TD, Jumppanen M, Hintsanen P, Suni V, Haapaniemi P, Corthals G, Aittokallio T, Westermarck J, Imanishi SY. Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling. Sci Rep. 2015 Aug 17;5:13099. Pubmed
Indira V. Chivukula, Daniel Ramsköld, Helena Storvall, Charlotte Anderberg, Shaobo Jin, Veronika Mamaeva, Cecilia Sahlgren, Kristian Pietras, Rickard Sandberg and Urban Lendahl. Decoding breast cancer tissue–stroma interactions using species-specific sequencing. Breast Cancer Research 2015, 17:109 Article
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
TEKES has awarded a FidiPro Professorship to Professor Peter James from Lund University, Department of Immunotechnology for the period 2016-2019. The Finnish host is Research Director Eleanor Coffey, Åbo Akademi, Turku Centre for Biotechnology
Arafath Kaja Najumudeen, Åbo Akademi University, 15th of January 2016: Targeting oncogenic signaling proteins - new insights using a FRET-based chemical biology approach
Asta Laiho, University of Turku, 9th of January 2016: Data analysis tools and methods for DNA microarray and high-throughput sequencing data
Sini Junttila, University of Turku, 8th of January 2016: Characterisation of Cladonia rangiferina transcriptome and genome, and the effects of dehydration and rehydration on its gene expression.
Pekka Heikkinen, University of Turku, 11th of December 2015: Modulation of TGF-β signaling by Hypoxia
Reetta Virtakoivu, University of Turku, 4th of December 2015: From epithelial to mesenchymal: regulation of invasive cancer cell motility From epithelial to mesenchymal: regulation of invasive cancer cell motility
Marika Sjöqvist, Åbo Akademi University, 13th of October 2015: Networking Notch : regulation of Notch traffic and signaling crosstalk
Mirkka Heinonen, University of Turku, 15th of September 2015: Players of Th-cell differentiation and immune dysregulation - focus on GIMAP family genes
Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis
Emilia Komulainen, Åbo Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks
Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation
Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain
Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification
Pertussis vaccine responses
Wednesday, February 10 at 11:15
PharmaCity Auditorium, ItÃ¤inen PitkÃ¤katu 4, Turku
Jay T Groves:
Signaling on membrane surfaces: the roles of space, force, and time
Thursday, February 11 at 12:00
Mauno Conference Center, President auditorium, BioCity, Turku
High resolution approaches applied to membrane proteins: said and done!
Thursday, February 11 at 12:00 - 15:15
Mauno Conference Center, President auditorium, BioCity, Turku
PET/CT in the diagnosis of cardiac implantable electronic device infections and endocarditis
Monday, February 15 at 15:00
PET Centre seminar room 1st floor (Kiinamyllynkatu 4-8, building #14)
in MC-ITN r'BIRTH project in Michale Courtneys group. Deadline for applications is February 28th, 2016.
in Academy of Finland Centre of Excellence at Turku Centre for Biotechnology led by Lahesmaa and Oresic. Deadline for applications is March 24, 2016.