Publications

Hot Off the Press

Äijö T, Butty V, Chen Z, Salo V, Tripathi S, Burge CB, Lahesmaa R, Lähdesmäki H. Methods for time series analysis of RNA-seq data with application to human Th17 cell differentiation. Bioinformatics. 2014 Jun 15;30(12):i113-i120. Pubmed

Kelkka T, Kienhoefer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R. Reactive oxygen species deficiency induces autoimmunity with downstream interferon signature. Antioxid Redox Signal. 2014 Apr 30. [Epub ahead of print] Pubmed

Coffey, E. Nuclear and cytosolic JNK signalling in neurons. Nat. Rev. Neurosci. 2014 Apr 17;15(5):285-99. Pubmed

Laine A, Westermarck J. Molecular Pathways: Harnessing E2F1 Regulation for Prosenescence Therapy in p53 Defective Cancer Cells. Clin Cancer Res. 2014 May 1. [Epub ahead of print] Pubmed

Guzmán C, Solman M, Abankwa D. Nanoclustering and heterogeneous membrane diffusion of Ras studied by FRAP and RICS analysis. Methods Mol Biol. 2014;1120:307-26. Pubmed

Papageorgiou AC & Mattsson J. Protein structure validation and analysis with x-ray crystallography. Methods Mol Biol. 2014; 1129:397-421. Pubmed

Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C. PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res. 2014 Mar 25 [Epub ahead of print]. Pubmed

Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol. 2014 Apr;15(4):384-92. Pubmed

Hämäläinen S, Nurminen N, Ahlfors H, Oikarinen S, Sioofy-Khojine AB, Frisk G,
Oberste MS, Lahesmaa R, Pesu M, Hyöty H. Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity. J Med Virol. 2014 Feb 20. [Epub ahead of print] Pubmed

Munukka E, Pekkala S, Wiklund P, Rasool O, Borra R, Kong L, Ojanen X, Cheng SM, Roos C, Tuomela S, Alen M, Lahesmaa R, Cheng S. Gut-adipose tissue axis in hepatic fat accumulation in humans. J Hepatol. 2014 Mar 5. pii: S0168-8278(14)00128-7. [Epub ahead of print] Pubmed

Noisa P, Lund C, Kanduri K, Lund R, Lähdesmäki H, Lahesmaa R, Lundin K,
Chokechuwattanalert H, Otonkoski T, Tuuri T, Raivio T. Notch signaling regulates neural crest differentiation from human pluripotent
stem cells. J Cell Sci. 2014 Feb 25. [Epub ahead of print] Pubmed

Kannaste O, Suomi T, Salmi J, Uusipaikka E, Nevalainen O, Corthals GL. Cross-correlation of spectral count ranking to validate quantitative proteome measurements. J Proteome Res. 2014 Mar 10. [Epub ahead of print] PubMed

Araújo JE, Oliveira EJ, Kouvonen P, Corthals GL, Lodeiro C, Santos HM, Capelo JL. A journey through PROTEOSONICS. In Press PubMed

Guzmán C, Bagga M, Kaur A, Westermarck J, Abankwa D. ColonyAreaw: An ImageJ plugin to automatically quantify colony formation in clonogenic assays. In press, PLoS One.

Guzmán C, Solman M, Ligabue A, Blazevitš O, Andrade DM, Reymond L, Eggeling C, Abankwa D. The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer specific nanoclustering. "Paper of the week". J Biol Chem. 2014 Feb 28. [Epub ahead of print] Pubmed  Press Release

Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin JC, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo KR, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinun M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky JW, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF, Burgess SM, Moir SL, Gadina M, Sood R, Hershfield MS, Boehm M, Kastner DL, Aksentijevich I. Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2. N Engl J Med. 2014 Feb 19. [Epub ahead of print] Pubmed

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Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!

News

Miljoonarahoitus aivosyövän uuden hoitostrategian kehittämiseen
Jane ja Aatos Erkon Säätiö on myöntänyt lähes miljoonan euron rahoituksen Turun ja Helsingin yliopistojen yhteiselle tutkijaryhmälle, joka pyrkii ratkaisemaan aivosyövän hoidon haasteita. Onnistuessaan hanke loisi mahdollisuudet merkittäviin läpimurtoihin syöpähoidoissa. Työryhmän johtaja Turun yliopiston professori Jukka Westermarck on yksi johtavista tämän tyyppisten syöpään vaikuttavien mekanismien tutkijoista. Westermarck työskentelee Turun Biotekniikan keskuksessa.

Johanna Ivaskasta Akatemiaprofessori
Suomen Akatemia myönsi viisivuotisen akatemiaprofessuurin molekulaarisen solubiologian professori Johanna Ivaskalle.

Recently Awarded PhDs

Tomoko Asaoka, Åbo Akademi University, 13th of December 2013: Regulation of cell fate by c-FLIP phosphorylation

Minna Kyläniemi, University of Turku, 4th of October 2013:
Regulation of lymphocyte response in vitro and in vivo

Nelly Rahkonen, University of Turku, 13th of September 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells

Saima Ferraris, Åbo Akademi University, 13th of August 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation

Anni Laine, University of Turku, 14th of June 2013, The role of an oncoprotein CIP2A in breast cancer.

Antti Arjonen, University of Turku, 14th of June 2013, Integrins on the move.

Soile Tuomela,  University of Turku, 26th of April 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.

Mari Björkman, University of Turku, 1st of March 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Therapeutic Development

Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics

Gunilla Högnäs, University of Turku, 8th of February 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion

Tapio Lönnberg, University of Turku, 26th of October 2012:
System-wide approaches to uncover Th2 cell lineage commitment

Elisa Närvä, University of Turku, 19th of October 2012:
Pluripotency and genetic stability of human pluripotent stem cells

Krista Rantanen, University of Turku, 12th of October 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival

 

Events

TuDMM Summer School

Several Speakers:
Epigenetics
Wednesday, August 13 at 11:15 - 13:00
Auditorium of Microbiological Institute, Kiinamyllynkatu 13

Special Seminar

Several speakers:
How to utilize new CSC computing resources in your research
Tuesday, August 19 at 10:00
Gamma Seminar room, ICT building

Symposium

Several Speakers:
The 25th Anniversary Symposium of Turku Centre for Biotechnology: Multidisciplinary approaches to battle cancer and immune mediated disease
Wednesday, August 20 at 8:30 - 17:30
Mauno Conference Center, President auditorium, BioCity, Turku

New Personnel

Ali Fawad

Trainee
 
Group:
Papageorgiou Tassos - Protein Crystallography

Beklen Arzu

Postdoctoral Fellow
 
Group:
Chen Zhi Jane - Lymphocytes and Inflammation

Rathinakannan Venkat

Trainee
 
Group:
Microarray and Sequencing