Joint SyMMyS and FiDiPro Symposium

Wednesday, August  26th, 2015
More information.

Publications

Hot Off the Press

Marek A. Budzynski, Mikael C. Puustinen, Jenny Joutsen, and Lea Sistonen. Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation.  Mol. Cell. Biol. July 2015 35:2530-2540. Pubmed

Li L-L, Melero-Fernandez de Mera RM, Chen J, Ba W, Nadif Kasri N, Zhang M, Courtney MJ. Unexpected heterodivalent recruitment of NOS1AP to nNOS reveals multiple sites for pharmacological intervention in neuronal disease models. J Neurosci. 2015 May 13;35(19):7349-64. Pubmed

Papageorgiou AC, Li D. Expression, purification and crystallization of a family 55 β-1,3-glucanase from Chaetomium thermophilum. Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):680-683. Epub 2015 May 20. Pubmed

De Franceschi N, Ivaska J. Integrin bondage: filamin takes control. Nat Struct Mol Biol. 2015 May 6;22(5):355-7. Pubmed

Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T. CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. Oncotarget. 2015 Apr 19. [Epub ahead of print] Pubmed

Heinonen MT, Laine AP, Söderhäll C, Gruzieva O, Rautio S, Melén E, Pershagen G, Lähdesmäki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R; Finnish Pediatric Diabetes Registry. GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy. J Immunol. 2015 May 11. [Epub ahead of print] Pubmed

Pipsa Saharinen and Johanna Ivaska. Blocking integrin inactivation as an anti-angiogenic therapy. EMBO J. 2015 Mar 31. [Epub ahead of print] Pubmed

Reetta Virtakoivu, Anja Mai, Elina Mattila, Nicola De Franceschi, Susumu Y Imanishi, Garry Corthals, Riina Kaukonen, Markku Saari, Fang Cheng, Elin Torvaldson, Veli-Matti Kosma, Arto Mannermaa, Ghaffar Muharram, Christine Gilles, John Eriksson, Ylermi Soini, James B. Lorens, and Johanna Ivaska. Vimentin-ERK signaling uncouples Slug gene regulatory function. Cancer Res. 2015 Apr 8. [Epub ahead of print] Pubmed

Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports. 2015, 4:519-528. Pubmed

Suni V, Imanishi SY, Maiolica A, Aebersold R, Corthals GL. Confident site localization using a simulated phosphopeptide spectral library. J Proteome Res. 2015 Mar 16. [Epub ahead of print] Pubmed

Tiannan Guo, Petri Kouvonen, Ching Chiek Koh, Ludovic C Gillet, Witold E Wolski, Hannes L Röst, George Rosenberger, Ben C Collins, Lorenz C Blum, Silke Gillessen, Markus Joerger, Wolfram Jochum & Ruedi Aebersold. Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps. Nature Medicine (2015). Published online 02 March 2015 doi:10.1038/nm.38071. Pubmed

Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort with HLA-Conferred Susceptibility. Diabetes. 2015 Jan 23. pii: db140983. [Epub ahead of print] Pubmed

Labrou NE, Papageorgiou AC, Pavli O, Flemetakis E. Plant GSTome: structure and functional role in xenome network and plant stress response. Curr Opin Biotechnol. 2015 Jan 19;32C:186-194. Pubmed

Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM. KSHV Viral Cyclin Interferes with T-Cell Development and Induces Lymphoma through CDK6 and Notch Activation in vivo. Cell Cycle. 2014 Sep 19:0. [Epub ahead of print] Pubmed

Ventelä S, Sittig E, Mannermaa L, Mäkelä JA, Kulmala J, Löyttyniemi E, Strauss L, Cárpen O, Toppari J, Grénman R, Westermarck J. CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance. Oncotarget. 2014 Dec 1. [Epub ahead of print] Pubmed

Skopelitou K, Muleta AW, Papageorgiou AC, Chronopoulou E & Labrou NE. Catalytic features and crystal structure of a tau class glutathione transferase from Glycine max specifically upregulated in response to soybean mosaic virus infections. Biochim Biophys Acta. 2014 Dec 2. [Epub ahead of print] Pubmed

Hrdlickova B, Kumar V, Kanduri K, Zhernakova DV, Tripathi S, Karjalainen J, Lund RJ, Li Y, Ullah U, Modderman R, Abdulahad W, Lähdesmäki H, Franke L, Lahesmaa R, Wijmenga C, Withoff S. Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity. Genome Medicine. 2014, 6:88. Pubmed

Trehan A, Rotgers E, Coffey ET, Huhtaniemi I, Rivero-Müller A. CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures. Cell Commun Signal. 2014 Nov 4;12(1):70. Pubmed

Komulainen E, Zdrojewska J, Freemantle E, Mohammad H, Kulesskaya N, Deshpande P, Marchisella F, Mysore R, Hollos P, Michelsen KA, Mågard M, Rauvala H, James P, Coffey ET. JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination. Front Cell Neurosci. 2014 Sep 12;8:272. Pubmed

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News

Molecular Systems Immunology groups awarded 2M€ grant
The Academy of Finland Center of Excellence in Molecular Systems Immunology and Physiology "SyMMyS" groups has been awarded a 2M€ grant from Academy of Finland pHealth programme for project "Personalised medicine to predict and prevent Type 1 Diabetes" (Lahesmaa - coordinator, Knip, Lähdesmäki, Oresic, Toppari, Lahti).

Links:

http://www.aka.fi/en/research-and-science-policy/programmes/current-programmes/phealth/

http://www.utu.fi/fi/Ajankohtaista/mediatiedotteet/Sivut/kohti-sairauksien-ehkaisemista-ja-raataloityja-hoitoja.aspx

Riitta Lahesmaalle akatemiaprofessuuri
Riitta Lahesmaa aloittaa viisivuotiskautensa akatemiaprofessorina vuoden 2016 alussa. Hän tutkii T-solujen kehitystä ja toimintaa. T-solut vastaavat elimistön immuunipuolustuksesta taudinaiheuttajia ja syöpää vastaan.

Professor Johanna Ivaska selected as EMBO member 2015
EMBO today announced that 58 outstanding researchers in the life sciences were elected to its membership. Fifty of the scientists reside in Europe and neighbouring countries; eight Associate Members were elected from China, Japan, New Zealand and the United States.

The latest scientists to join EMBO come from 19 different countries and include 18 female scientists recognized for their contributions to life science research. The EMBO Membership currently comprises more than 1700 life scientists.

Link to EMBO press release:

http://www.embo.org/news/press-releases/press-releases-2015/embo-announces-new-members-for-2015

New Ways to Shut Down Signals Involved in Brain Diseases
A research team based at the University of Eastern Finland and the Turku Centre for Biotechnology have found new ways to block a pathway that may be responsible for several brain disorders, which could open the door to developing better treatments.

Recently Awarded PhDs

Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis

Emilia Komulainen, Åbo  Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks

Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation

Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain

Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification

Tomoko Asaoka, Åbo Akademi University, 13th of December 2013: Regulation of cell fate by c-FLIP phosphorylation

Minna Kyläniemi, University of Turku, 4th of October 2013:
Regulation of lymphocyte response in vitro and in vivo

Nelly Rahkonen, University of Turku, 13th of September 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells

Saima Ferraris, Åbo Akademi University, 13th of August 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation

Anni Laine, University of Turku, 14th of June 2013, The role of an oncoprotein CIP2A in breast cancer.

Antti Arjonen, University of Turku, 14th of June 2013, Integrins on the move.

Soile Tuomela,  University of Turku, 26th of April 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.

Mari Björkman, University of Turku, 1st of March 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Therapeutic Development

Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics

Gunilla Högnäs, University of Turku, 8th of February 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion

Tapio Lönnberg, University of Turku, 26th of October 2012:
System-wide approaches to uncover Th2 cell lineage commitment

Elisa Närvä, University of Turku, 19th of October 2012:
Pluripotency and genetic stability of human pluripotent stem cells

Krista Rantanen, University of Turku, 12th of October 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival

 

Events

Special Seminar

Several speakers:
Bridging Nordic Imaging - Enabling discoveries from atoms to anatomy
Thursday, August 13 at 9:00 - Friday, August 14 at 16:00
Arken, Ã…bo Akademi, Fabriksgatan 2, 20500 Ã…bo

Symposium

Several speakers:
New insights into type 1 diabetes
Wednesday, August 26 at 8:30
Mauno Conference Center, President auditorium, BioCity, Turku

Symposium

Several speakers:
The BioCity Student Symposium - Life in science
Wednesday, August 26 at 9:00 - 16:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4 B, Turku

New Personnel

Pavic Karolina

Postdoctoral Fellow
 
Group:
Westermarck Jukka - Cancer Cell Signaling

Metsälä Olli

Undergraduate student
 
Group:
Jaakkola Panu - Hypoxia Group

Kakko Lauri

Undergraduate Student
 
Group:
Microarray and Sequencing

Mäki Frans

IT-support
 
Group:
Technical staff

Mehmood Arfa

Graduate Student
 
Group:
Elo Laura - Computational Biomedicine