Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Hot Off the Press
Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin JC, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo KR, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinun M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky JW, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF, Burgess SM, Moir SL, Gadina M, Sood R, Hershfield MS, Boehm M, Kastner DL, Aksentijevich I. Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2. N Engl J Med. 2014 Feb 19. [Epub ahead of print] Pubmed
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R. Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes. 2014 Feb 18. [Epub ahead of print] Pubmed
Zhang J, Niemelä M, Westermarck J, Rosenholm JM. Mesoporous silica nanoparticles with redox-responsive surface linkers for charge-reversible loading and release of short oligonucleotides. Dalton Trans. 2014 Jan 24. [Epub ahead of print] Pubmed
Lehtimäki S, Lahesmaa R. Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features. Front Immunol. 2013 Sep 23;4:294. Review. Pubmed
Zdrojewska, J., Coffey, E.T. The Impact of JNK on Neuronal Migration. Adv Exp Med Biol. 2014;800:37-57. Pubmed
Finn R, Ahmad T, Coffey ET, Brayden DJ, Baird AW, Boyd A. Translocation of Vibrio parahaemolyticus across an in vitro M cell model. FEMS Microbiol Lett. 2013 Nov 5. doi: 10.1111/1574-6968.12323. Pubmed
Elo LL and Schwikowski B. Analysis of Time-Resolved Gene Expression Measurements Across Individuals. PLoS ONE 8(12): e82340, 2013.
Tuomela S, Lahesmaa R.. Early T helper cell programming of gene expression in human. Semin Immunol. 2013 Nov 15;25(4):282-90. Pubmed
McDonnell LA, Walch A, Stoeckli M, Corthals GL. MSiMass List: A Public Database of Identifications for Protein MALDI MSI. J Proteome Res. 2013 Dec 6. Pubmed
Haikarainen T, Frioux C, Zhnag LQ, Li DC & Papageorgiou AC. Crystal structure and biochemical characterization of a manganese superoxide dismutase from Chaetomium thermophilum. Biochim Biophys Acta. 2013 Dec 3. Pubmed
Dominique Böcking, Oliver Wiltschka, Jenni Niinimäki, Hussein Shokry, Rolf Brenner, Mika Lindén and Cecilia Sahlgren. Mesoporous silica nanoparticle-based substrates for cell directed delivery of Notch signalling modulators to control myoblast differentiation. Nanoscale 2014 Advanced article.
Seyednasrollah F, Laiho A, Elo LL. Comparison of software packages for detecting differential expression in RNA-seq studies. Briefings in Bioinformatics 2013.
Närvä E, Pursiheimo JP, Laiho A, Rahkonen N, Emani MR, Viitala M, Laurila K, Sahla R, Lund R, Lähdesmäki H, Jaakkola P, Lahesmaa R. Continuous Hypoxic Culturing of Human embryonic Stem Cells Enhances SSEA-3 and MYC Levels. PLoS One. 2013 Nov 13;8(11):e78847. Pubmed
Sainio A, Nyman M, Lund R, Vuorikoski S, Boström P, Laato M, Boström PJ, Järveläinen H. Lack of decorin expression by human bladder cancer cells offers new tools in the therapy of urothelial malignancies. PLoS One. 2013 Oct 11;8(10):e76190. Pubmed
A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation. Vuoristo S, Toivonen S, Weltner J, Mikkola M, Ustinov J, Trokovic R, Palgi J, Lund R, Tuuri T, Otonkoski T. PLoS One. 2013 Oct 2;8(10):e76205. Pubmed
Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J.SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes.Cell Rep. 2013 Nov 5. pii: S2211-1247(13)00580-9. Pubmed
Westermarck J, Ivaska J, Corthals GL. Identification of protein interactions involved in cellular signaling. Mol Cell Proteomics. 2013 Jul;12(7):1752-63. Pubmed
Khanna A, Pimanda JE, Westermarck J. Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target. Cancer Res. 2013 Nov 7. Pubmed
Khanna A, Kauko O, Böckelman C, Schreck I, Szwadja A, Laine A, Partanen J, Pokharel Y, Helenius M, Russel M, Haglund C, Cole K, Klefström J, Aittokallio T, Weiss C, Ristimäki A, Visakorpi T and Westermarck J. Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells. Cancer Research, Published OnlineFirst September 26, 2013. Pubmed
Jendrossek, D., Hermawan, S., Subedi, B. & Papageorgiou, A.C. Biochemical analysis and structure determination of poly(3-hydroxybutyrate) (PHB) depolymerase PhaZ7 muteins reveal the PHB binding site and details of substrate-enzyme interactions. Mol. Microbiol. 2013 Sep 5 [Epub ahead of print] Pubmed
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors and x-ray crystallography. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
Minna Kyläniemi, University of Turku, 4th of October, 2013:
Regulation of lymphocyte response in vitro and in vivo
Nelly Rahkonen, University of Turku, 13th of September, 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells
Saima Ferraris, Åbo Akademi University, 13th of August, 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation
Soile Tuomela, University of Turku, 26th of April, 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.
Mari Björkman, University of Turku, 1st of March, 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
Gunilla Högnäs, University of Turku, 8th of February, 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion
Tapio Lönnberg, University of Turku, 26th of October, 2012:
System-wide approaches to uncover Th2 cell lineage commitment
Elisa Närvä, University of Turku, 19th of October, 2012:
Pluripotency and genetic stability of human pluripotent stem cells
Krista Rantanen, University of Turku, 12th of October, 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
NORDIC PROTEOMICS CONFERENCE on QUANTITATIVE PROTEOMICS
Tuesday, March 11 at 9:00 - Thursday, March 13 at 15:00
Radisson Blu Marina Palace Hotel, Turku
Whole genome sequencing of Mycobacterium tuberculosis in outbreak investigations
Wednesday, March 12 at 11:15
Auditorium of Microbiological Institute, Kiinamyllynkatu 13
IncuCyte imaging platform
Wednesday, March 12 at 14:00
Turku Center for Biotechnology seminar room, BioCity B stairs, 5th floor
Prof. Yardena Samuels:
Mutational and Functional analysis of melanoma filling in the gap
Thursday, March 13 at 12:00
Ravintola Mauno, President auditorium, Biocity, Turku
A Laboratory technician position until the end of 2016 is available in the research groups of Professor Johanna Ivaska and Professor Jukka Westermarck at Turku Centre for Biotechnology, University of Turku. The main task is to establish a novel breast cancer mouse model in cooperation with the researchers, and to participate in various types of laboratory animal work, e.g. genotyping. Also, the technician will help the researchers in several other laboratory tasks.
A PhD student position is available in the research group of Dr. Jeroen Pouwels in the Centre for Biotechnology of the University of Turku. The position is available from May first 2014. The research will focus on the characterization of Sharpin, a functional integrin inhibitor.
We are seeking an ambitious research director to establish an independent research group at the Centre. A successful candidate is expected to develop a line of independent research through competitive external funding. The candidate would be expected to train M.Sc. and doctoral students from the University of Turku and contribute to the teaching portfolio in her/his area of expertise.