Publications

Hot Off the Press

Mahesh Tambe*, Sofia Pruikkonen*, Jenni Mäki-Jouppila, Ping Chen, Bente Vilming Elgaaen, Anne Hege Straume, Kaisa Huhtinen, Olli Cárpen, Per Eystein Lønning, Ben Davidson, Sampsa Hautaniemi and Marko J. Kallio. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel. Oncotarget Mar 2, 2016. *equal contribution. PubMed

Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Söderström M, Emani MR, Stubb A, Närvä E, Ghimire B, Laiho A, Järveläinen H, Lahesmaa R, Lähdesmäki H, Hawkins RD, Lund RJ. Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells. Sci Rep. 2016 Feb 25;6:22190. Pubmed

Kohtala S, Theilmann W, Suomi T, Wigren HK, Porkka-Heiskanen T, Elo LL, Rokka A, Rantamäki T. Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus. ACS Chem Neurosci. 2016 Apr 28. [Epub ahead of print] Pubmed

Conesa A, Madrigal P, Tarazona S, Gomez-Cabrero D, Cervera A, McPherson A, Szcześniak MW, Gaffney DJ, Elo LL, Zhang X, Mortazavi A. A survey of best practices for RNA-seq data analysis. Genome Biol. 2016 Jan 26;17:13. Pubmed

Santio N, Landor S, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi S, Corthals G, Varjosalo M, Manoharan G, Uri A, Lendahl U, Sahlgren C* &  Koskinen P*. Pim kinases regulate oncogenic Notch1 signaling. Oncotarget. Link

Braune EB, Tsoi YL, Phoon YP, Landor S, Silva Cascales H, Ramsköld D, Deng Q, Lindqvist A, Lian X, Sahlgren C, Jin SB, Lendahl U. Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells. Stem Cell Reports. 2016 Apr 4. E-pub ahead of print. Pubmed

Ba W, Selten MM, van der Raadt J, van Veen H, Li LL, Benevento M, Oudakker AR, Lasabuda RS, Letteboer SJ, Roepman R, van Wezel RJ, Courtney MJ, van Bokhoven H, Nadif Kasri N. ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function. Cell Rep. 2016 Feb 16;14(6):1355-68. Pubmed

Skopelitou K, Muleta AW, Papageorgiou AC, Chronopoulou EG, Pavli O, Flemetakis E, Skaracis GN, Labrou NE. Int J Biol Macromol. 2016 Pubmed

Christophe Côme, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimente, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H. Busch, Markus W. Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4) e0152996. Link

Padzik A*, Deshpande P*, Hollos P*, Franker M, Rannikko EH, Cai D, Prus P, Mågård M, Westerlund N, Verhey KJ, James P, Hoogenraad CC, Coffey ET. KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons.  Front Cell Neurosci. 2016 Mar 15;10:57. *equal contribution. Pubmed

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers. Sami Ventelä, Juho-Antti Mäkelä, Rosalie Sears C, Jorma Toppari, Jukka Westermarck. Matters, Mar 03, 2016. Link

A K Najumudeen, A Jaiswal, B Lectez, C Oetken-Lindholm, C Guzmán, E Siljamäki, I MD Posada, E Lacey, T Aittokallio, D Abankwa. Cancer stem cell drugs target K-ras signaling in a stemness-context. Oncogene. 2016 Mar 14. [Epub ahead of print] Pubmed

Guzman C, Oetken-Lindholm C, Abankwa D. Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions. J Lab Autom 21(2):238-45 Pubmed

Ratcliffe CD*, Sahgal P*, Parachoniak CA, Ivaska J, Park M. * equal contribution. Regulation of cell migration and ß1 integrin trafficking by the endosomal adaptor GGA3. Traffic 2016 Mar 3 [Epub ahead of print] Pubmed

Mamaeva V, Niemi R, Beck M, Özliseli E, Desai D, Landor S, Gronroos T, Kronqvist P, Pettersen IK, McCormack E, Rosenholm JM, Linden M, Sahlgren C. Inhibiting Notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ- secretase inhibitors. Mol Ther. 2016 Feb 26. [Epub ahead of print]. Pubmed

Najumudeen AK, Posada IM, Lectez B, Zhou Y, Landor SK, Fallarero A, Vuorela P, Hancock J, Abankwa D. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. Biochemistry. 2015 Dec 15;54(49):7212-21. Pubmed

Guzmán C, Oetken-Lindholm C, Abankwa D. Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein-Protein Interactions. J Lab Autom. 2015 Sep 17. Pubmed

Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzmán C, Härmä H, Hancock JF, Aittokallio T, Abankwa D. Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation. Elife. 2015 Aug 14;4:e08905. Pubmed

General information on Turku can be found here.

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We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.

Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!

News

Biomathematician Laura Elo Received Highly Competitive ERC Funding
Adjunct professor of Biomathematics Laura Elo from University of Turku has received a grant from the European Research Council (ERC). The grant is one of the most highly competitive grants in Europe. The ERC Starter Grant is 1.5 million euros.

New Experimental Drug Blocks One of the Most Notorious Cancer Drivers

Laura Elo mukana Nainen + Laskennallinen tiede = Täydellinen yhtälö -kampanjassa

Linnéa Linko received quality improvement award

Some of Our Recently Awarded PhDs

Riina Kaukonen, University of Turku, 22nd of April 2016, Filopodia and stromal extracellular matrix as regulators of cancer cell invasion and growth

Hasan Mohammad, Åbo Akademi University, 6th of April, 2016: JNK regulation of neurogenesis, neuroplasticity and anxiety-related behaviors in mice

Nicola De Franceschi,  University of Turku, 12th of February 2016: Integrin cytoplasmic tail interactors: the insiders' game.  

Arafath Kaja Najumudeen, Åbo Akademi University, 15th of January 2016: Targeting oncogenic signaling proteins - new insights using a FRET-based chemical biology approach

Asta Laiho, University of Turku, 9th of January 2016: Data analysis tools and methods for DNA microarray and high-throughput sequencing data

Sini Junttila, University of Turku, 8th of January 2016: Characterisation of Cladonia rangiferina transcriptome and genome, and the effects of dehydration and rehydration on its gene expression.

Pekka Heikkinen, University of Turku, 11th of December 2015: Modulation of TGF-β signaling by Hypoxia

Reetta Virtakoivu, University of Turku, 4th of December 2015: From epithelial to mesenchymal: regulation of invasive cancer cell motility From epithelial to mesenchymal: regulation of invasive cancer cell motility

Marika Sjöqvist, Åbo Akademi University, 13th of October 2015: Networking Notch : regulation of Notch traffic and signaling crosstalk

Mirkka Heinonen,  University of Turku, 15th of September 2015:  Players of Th-cell differentiation and immune dysregulation - focus on GIMAP family  genes

Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis

Emilia Komulainen, Åbo  Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks

Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation

Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain

Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification

Events

BioCity Turku Guest seminar

Christa E. Müller :
Medicinal Chemistry of Purinergic Signalling Focusing on Inflammation and Cancer
Thursday, June 2 at 12:00
PharmaCity Auditorium, Itäinen Pitkäkatu 4, Turku

Special Seminar

Several speakers:
NMR in Turku: versatile possibilities of NMR in several fields of science and new prospects in future research
Thursday, June 2 at 12:15
Arcanum lecture hall Arc1

BioCity Turku Research Programme event

CompLifeSci Research Programme kick off meeting
Friday, June 3 at 9:00
Alpha Auditorium, ICT building, Joukahaisenkatu 3-5, Turku

Lost In Imaging Seminar

Markku Saari:
Contrast methods in light microscopy
Friday, June 3 at 14:00
Turku Centre for Biotechnology seminar room, BioCity B stairs, 5th floor

Special Seminar

Cristina Scielzo:
Molecular and functional characterization of HS1 protein: a prognostic factor and therapeutic target in Chronic Lymphocytic Leukemia
Monday, June 6 at 10:15
PharmaCity Auditorium, Itäinen Pitkäkatu 4, Turku

BioCity Turku Research Programme event

Several speakers:
New BioCity Turku Research Programmes
Monday, June 6 at 13:00
Mauno Conference Center, President auditorium, BioCity, Turku

TuDMM Summer School

TuDMM Summer School 2016:
Microbes R Us
Tuesday, June 7 at 12:15
Dentalia Auditorium (Arje Scheinin), 2nd floor, Lemminkäisenkatu 2

Careers

Postdoctoral researcher in Computational Biomedicine

is open for applications in the Computational Biomedicine Group of Dr. Laura Elo. The position must be applied by June 5th, 2016.

New Personnel

Tripathi Subhash

Postdoctoral Fellow
 
Group:
Lahesmaa Riitta - Molecular Immunology

Nikita Tiwari

Undergraduate Student
 
Group:
Coffey Eleanor - Kinase Function in Brain

Klén Riku

Postdoctoral Fellow
 
Group:
Elo Laura - Computational Biomedicine

Dickens Alex

Postdoctoral Fellow
 
Group:
Oresic Matej - Systems Medicine

Starskaia Inna

Graduate Student
 
Group:
Chen Zhi Jane - Lymphocytes and Inflammation

Shetty Ankitha

Graduate Student
 
Group:
Lahesmaa Riitta - Molecular Immunology

Laporte Sophie

Trainee
 
Group:
Papageorgiou Tassos - Protein Crystallography