Selected recent publications
Key publications
Ahlfors H, Limaye A, Elo-Uhlgrén L, Notani D, Gottimukkala K, Burute M, Tuomela S, Rasool O, Galande S* & Lahesmaa R*. SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation. Submitted. *Equal contribution. (Accepted for Blood)
Moulder R*, Lönnberg T*, Filén J-J, Elo L, Rainio E, Corthals G, Oresic M, Nyman TA, Aittokallio T, Lahesmaa R (*equal contribution). Quantitative Proteomics Analysis of the Nuclear Fraction of Human CD4+ Cells in the Early Phases of IL-4 Induced Th2 Differentiation. Molecular Cellular Proteomics, accepted for publication.
Närvä E, Autio R, Rahkonen N, Kong L, Harrison N, Kitsberg D, Borghese L, Itskovitz-Eldor J, Rasool O, Dvorak P, Hovatta O, Otonkoski T, Tuuri T, Cui W, Brüstle O, Baker D, Maltby E, Moore HD, Benvenisty N, Andrews PW, Yli-Harja O, Lahesmaa R. High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nature Biotechnology. 2010 Mar 28. [Epub ahead of print]
Filén S, Ylikoski E, Tripathi S, West A, Björkman M, Nyström J, Ahlfors H, Coffey E, Rao KV, Rasool O, Lahesmaa R. Activating transcription factor 3 is a positive regulator of human IFNG gene expression. J Immunol. 2010 May 1;184(9):4990-9. Epub 2010 Mar 19.
Cho SH, Goenka S, Henttinen T, Gudapati P, Reinikainen A, Lahesmaa R, Boothby M. PARP-14, a member of the B aggressive lymphoma (BAL) family, transduces survival signals in primary B cells. Blood. 2009 Mar 12;113(11):2416-25. Epub 2009 Jan 15.
Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R. Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling. J Autoimmun. 2010 Mar 29. [Epub ahead of print]
Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med. 2008 Dec 22;205(13):2975-84. Epub 2008 Dec 15.
Rautajoki K, Tuomela S, Moulder R, Nyman T, Lahesmaa R. Identification of novel Stat6 regulated proteins in IL-4 treated mouse lymphocytes. Proteomics. 2009 Feb;9(4):1087-98.
Tahvanainen J, Kallonen T, Lähteenmäki H, Heiskanen K, Westermarck J, Rao KV and Lahesmaa R. PRELI is a mitochondrial regulator of human primary T helper cell apoptosis, STAT6 and Th2 cell differentiation. Blood, Oct 22. (Epub ahead of printing)
Filén JJ, Filén S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Björkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R. Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation. Mol Cell Proteomics. 2008 Aug 12. (Epub ahead of printing)
Kumar D, Srikanth R, Ahlfors H, Lahesmaa R, Rao KV. Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response. Molecular Systems Biology, 2007:3:150.
Lund RJ*, Loytomaki M*, Naumanen T, Dixon C, Chen Z, Ahlfors H, Tuomela S, Tahvanainen J, Scheinin J, Henttinen T, Rasool O, Lahesmaa R. Genome Wide Identification of Novel Genes Involved in Early Th1 and Th2 Cell Differentiation. J Immunol. 2007Mar 15;178(6):3648-60. *Equal contribution
Rautajoki KJ, Marttila EM, Nyman TA, Lahesmaa R. IL-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human Th2 cell differentiation. Mol Cell Proteomics. 2007 Feb;6(2):238-251. Epub 2006 Nov 17.
Hahtola S, Tuomela S, Elo L, Hakkinen T, Karenko L, Nedoszytko B, Heikkila H, Saarialho-Kere U, Roszkiewicz J, Aittokallio T, Lahesmaa R, Ranki A. Th1 response and cytotoxicity genes are down-regulated in cutaneous T-cell lymphoma. Clin Cancer Res. 2006, 12(16):4812-21.
Tahvanainen J, Pykalainen M, Kallonen T, Lahteenmaki H, Rasool O, Lahesmaa R. Enrichment of nucleofected primary human CD4+ T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation. J Immunol Meth 2006, 310(1-2):30-9.
Pykäläinen M, Kinos R, Valkonen S, Rydman P, Kilpeläinen M, Laitinen LA, Karjalainen J, Nieminen M, Hurme M, Kere J, Laitinen T, Lahesmaa R. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol. 2005 115:80-7.
Skottman H, Mikkola M, Lundin K, Olsson C, Strömberg A-M, Tuuri T, Otonkoski T, Hovatta O, Lahesmaa R. Gene expression signatures of seven individual human embryonic stem cell lines. Stem Cells 2005, 23 (9):1343-56.
Lund R, Chen Z, Scheinin J, Lahesmaa, R. Early target genes of IL-12/STAT4 signaling in T helper cells. J. Immunol., 2004; 172:6775-82.
Lund, R, Aittokallio, T, Nevalainen, O and Lahesmaa, R. Identification of novel genes regulated by IL-12, IL-4 and TGFb during the early polarization of CD4+ lymphocytes. J. Immunol., 2003, 171:5328-5336.
Chen Z, Lund R, Aittokallio T, Kosonen M, Nevalainen O, Lahesmaa R. Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol., 2003, 171:3627-3635.
Hamalainen H, Zhou H, Chou W, Hashizume H, Heller R, Lahesmaa R. Distinct gene expression profiles of human type 1 and type 2 T helper cells.
Genome Biol. 2001;2(7):RESEARCH0022.