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A Senior researcher/ Postdoctoral Fellow at The Finnish Microarray and Sequencing Centre (FMSC)


at the Turku Centre for Biotechnology for the period of September 1, 2010 – December 31, 2012.

We are seeking for a scientist to be responsible for implementing and developing data analysis methods for new next-generation and single molecule sequencing platforms for epigenetic and transcriptomics applications together with our senior scientists. Participation to collaborative research projects as well as establishing an indpendent line of reserach is highly encouraged.

FMSC is an internationally recognized Functional Genomics Core Facility with state-of-the-art research platforms for next generation and single molecule sequencing.  FMSC is part of the Turku Centre for Biotechnology (www.btk.fi), a joint institute of the University of Turku and Åbo Akademi University and a vibrant research Centre with state-of-the-art core facilities.

Successful candidates are expected to have Ph.D. in bioinformatics, computational systems biology, computer sciences, mathematics/statistics and publication track record in a relevant field. Candidates with prior experience in interdisciplinary research projects are preferred.

Salary
The salary is in accordance with the State’s salary system (Universities) for teaching and research personnel level 5-6 (Senior Researcher/postdoctoral fellow), where the work specific salary component is between 2636 – 3132 €/month. In addition, there is a share increase based on the personal performance, which is, at most, 46% of the base salary.

Applications
Please send your CV, list of publications, a brief statement of your research interests/reserach plan /(max. 3 pages) and contact information for three references by e-mail to coordinator Satu Alanko at satu.alanko (at) btk.fi

Application period has been prolonged and the new closing date for the applications is September 13, 2010 at 3.45 pm.

For further information please contact Riitta Lahesmaa, e-mail: riitta.lahesmaa (at) btk.fi. For more information about the Centre: www.btk.fi

PhD and Postdoctoral Projects at the Centre for Biotechnology (CBT) in Turku


PhD and Postdoctoral Projects - A novel, fundamental mechanism of how small GTPases operate on the membrane

We are looking for highly motivated and ambitious candidates for PhD students, as well as Postdocs, who are interested to join our young and interactive research group at the Centre for Biotechnology (CBT) in Turku/Abo.

The CBT offers state-of-the-art research facilities for bioimaging, proteomics, genomics, crystallography, which support excellence in research in Turku. The Cell Imaging Core boasts top equipment for life-cell imaging, high-contentent and confocal microscopy, as well as state of the art FACS service and high-throughput flow cytometry. It currently also serves as the Nordic reference site for the Leica STimulated Emission Depletion (STED)- superresolution microscope.

Our research focuses on the membrane organization and signaling activity of small GTPases of the Ras-, Rho- and Rab-family. We have recently described a novel membrane-orientation switch III region for Ras proteins, which profoundly influences their biology (Abankwa D et al. (2008) A novel switch region regulates H-ras membrane orientation and signal output. Embo J 27(5): 727-735; Abankwa D et al. (2010) Ras membrane orientation and nanodomain localization generate isoform diversity. Proc Natl Acad Sci U S A 107(3): 1130-1135). We propose a model that explains the long standing biological question of how specificity of the more than 150 small GTPases is structurally defined.

We are planning to address several exciting questions around this newly discovered mechanism that touch on the fundamentals of small GTPase biology. We will be using cutting-edge imaging (Fluorescence Lifetime Imaging Microscopy, FLIM and STED), high- throughput methodological approaches (high-content and cytometer chemical- and RNAi- screening, curvature assay on vesicles) and animal models.

There will be possibilities to visit our collaborators during in Australia, Europe and the USA in the projects!

We are looking for:
Biochemists, Chemists, (Bio)Physicists or Bioinformations with experience and/or interest in the following areas:
•Protein purification
•Fluorescence imaging (confocal microscopes or wide field)
•Flow cytometry
•Animal cancer models
•Molecular biology
•Cell biology (transformation assays)
•Programming (ideally image data treatment)

Experience in at least one of the above areas is required for a candidate to be considered.

Please send preferably as one merged pdf: a short CV that highlights your most outstanding achievements, as well as the email contacts of 1-2 referees (these may also be course advisors) and a brief description of your motivation to join the group (less than an A4 page) to daniel.abankwa-at-btk.fi  with the subject line ‘research candidate’. For more information, visit: http://www.btk.fi/   (group webpage updated shortly)


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