Selected Publications
Khanna A*, Böckelman C*, Hemmes A, Junttila MR, Wiksten J-P, Lundin P, Junnila S, Murphy D, Evan GI, Haglund C, Westermarck J*, and Ristimäki A* (2009). C-Myc-dependent regulation and prognostic role of CIP2A in gastric cancer. Journal of The National Cancer Institute, 101:793-805.
Wu J, Ovaska K, Vallenius T, Westermarck J, Mäkelä TP, and Hautaniemi S; Protein-protein interaction portal for network level analysis. Nature Methods, 6, 75-77, 2009.
Tahvanainen J, Kallonen T, Lähteenmäki H , Heiskanen K, Westermarck J, Rao KVS, and Lahesmaa R; PRELI, a novel mitochondrial regulator of human primary T helper cell apoptosis, STAT6 and Th2 cell differentiation. Blood, 113, 1268-1277, 2009.
Blomster, H.A., Hietakangas, V., Wu, J., Kouvonen, P., Hautaniemi, S. & Sistonen, L. (2009). Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites. Mol. Cell. Proteomics, 8:1382-1390.
Westerheide, S.D.*, Anckar, J.*, Stevens, S.M.Jr., Sistonen, L. & Morimoto, R.I. (2009). Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science, 323:1063-1066.
Cho SH, Goenka S, Henttinen T, Gudapati P, Reinikainen A, Lahesmaa R, Boothby M. (2009) PARP-14, a member of the B aggressive lymphoma (BAL) family, transduces survival signals in primary B cells. Blood. 113:2416-2425.
Filén JJ, Filén S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Björkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R. (2009). Quantitative Proteomics Reveals GIMAP Family Proteins 1 and 4 to Be Differentially Regulated during Human T Helper Cell Differentiation. Mol Cell Proteomics, 8:32-44.
Brandt, DT., Baarlink, C., Kitzing, TM., Kremmer, E., Ivaska, J., Nollau, P. and Grosse, R. (2009). SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of b1-integrin. Nat. Cell. Biol., 11:557-568.
Tuomi, S., Mai, A., Nevo, J., Öhman, T.J., Gahmberg, C.G., Parker, P.J. and Ivaska, J. (2009) a5-integrin-ZO-1 complex controls a migration switch in cancer cells (In Press, Science Signaling).
Morfini, G.A., You, Y.M., Pollema, S.L., Kaminska, A., Liu, K., Yoshioka, K., Björkblom, B., Coffey, E.T., Bagnato, C., Han, D., Huang, C.F., Banker, G., Pigino, G. & Brady, S.T. 2009. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat. Neurosci., 12:864-871.
Rosenholm, J.M., Peuhu, E., Eriksson, J.E., Sahlgren, C. & Lindén, M. 2009. Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems. Nano Lett., 9:3308-3311.
Cheng, F., Weidner-Glunde, M., Varjosalo, M., Rainio, E.M., Lehtonen, A., Schulz, T.F., Koskinen, P.J., Taipale, J. & Ojala, P.M. 2009. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathog., 5(3):e1000324.
Pellinen T., Tuomi, S., Arjonen, A., Wolf, M., Edgren, H., Meyer, H., Grosse, R., Kitzing, T., Rantala, JK., Kallioniemi O., Fässler, R., Kallio, M., and Ivaska, J. (2008) Integrin traffic regulated by Rab21 is necessary for cytokinesis. (Dev. Cell, 15:371-385.).
Varjosalo M, Björklund M, Cheng F, Syvänen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He, W-W, Ojala P, Taipale J. Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling. Cell 133, 537 – 548, 2008
Oresic, M., Simell, S., Sysi-Aho, M., Näntö-Salonen, K., Seppänen-Laakso, T., Parikka, V., Katajamaa, M., Hekkala, A., Mattila, I., Keskinen, P., Yetukuri, L., Reinikainen, A., Lähde, J., Suortti, T., Hakalax, J., Simell, T., Hyöty, H., Veijola, R., Ilonen, J., Lahesmaa, R., Knip, M. & Simell, O. (2008). Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J. Exp. Med., 205:2975-2984.
Åkerfelt, M*., Henriksson, E*., Laiho, A., Vihervaara, A., Rautoma, K., Kotaja, N. & Sistonen, L. (2008). Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2. Proc. Natl. Acad. Sci. U S A, 105:11224-11229.
Semanova, M.M., Mäki-Hokkanen, A.M.J., Cao, C., Komarovski, V., Forsberg, K.M., Koistinaho, M., Coffey, E.T., Courtney, M.J. (2007) Rho mediates calcium-dependent activation of p38a and subsequent excitotoxic cell death. Nature Neuroscience, 10(4):436-443.
Imanishi, S.Y., Kochin, V., Ferraris, S.E., de Thonel, A., Pallari, H.M., Corthals, G.L. & Eriksson, J.E. (2007). Reference-facilitated phosphoproteomics: fast and reliable phosphopeptide validation by microLC-ESI-Q-TOF MS/MS. Mol.Cell. Proteomics, 6:1380-1391.
Rautajoki, K.J., Marttila, E.M., Nyman, T.A., Lahesmaa, R. (2007).Interleukin-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human T helper 2 cell differentiation. Mol. Cell. Proteomics, 6:238-251.
Junttila, MR., Puustinen, P., Niemelä, M., Ahola, R., Nielsen, C., Kallunki, T., Ivaska, J., Arnold, H., Lu, SL., Wang, XJ., Kähäri, VM., Westermarck, J. (2007) CIP2A inhibits PP2A in Human Malignancies. Cell 130:51-62.
Taussig MJ, Stoevesandt O, Borrebaeck CAK, Kallioniemi O, Saviranta P et al. (41 authors). ProteomeBinders: Planning a European resource of affinity reagents for analysis of the human proteome. Nature Methods 4(1), 13 – 17, 2007
Nagy, E., Balogi, Z., Gombos, I., Åkerfelt, M., Björkbom, A., Balogh, G., Torok, Z., Maslyanko, A., Fiszer-Kierzkowska, A., Lisowska, K., Slotte, P.J., Sistonen, L., Horvath, I. & Vigh, L. (2007). Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line. Proc. Natl. Acad. Sci. U S A, 104:7945-7950.
Junttila, MR*, Puustinen P*, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Li S, Chan EKL, Wang X-J, Grenman R, Kast J, Kallunki T, Sears R, Kähäri V-M, Westermarck J; CIP2A Inhibits PP2A in Human Malignancies. Cell, 130, 51–62, 2007.
Tararuk T, Ostman N, Li W, Bjorkblom B, Padzik A, Zdrojewska J, Hongisto V, Herdegen T, Konopka W, Courtney MJ, Coffey E.T.* (2006) JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. Journal of Cell Biology, 173(2):265-77.
Nieminen, M., Henttinen, T., Merinen, M., Marttila-Ichihara, F., Eriksson, J.E. & Jalkanen, S. (2006). Vimentin function in lymphocyte adhesion and transcellular migration. Nat. Cell Biol., 8:156-162.
Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J. (2006) Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J. Cell Biol. 173:767-80.
Rischer, H., Oresic, M., Seppänen-Laakso, T., Katajamaa, M., Lammertyn, F., Ardiles-Diaz, W., Van Montagu, M.C., Inze, D., Oksman-Caldentey, K.M. & Goossens, A. (2006). Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proc. Natl. Acad. Sci. USA, 103:5614-5619.
Edgren H, Kallioniemi O (2006). Integrated breast cancer genomics. Cancer Cell 6: 453-455
Hietakangas, V*., Anckar, J*., Blomster, H.A., Fujimoto, M., Palvimo, J.J., Nakai, A. & Sistonen, L. (2006). PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl. Acad. Sci. USA, 103:45-50.
Chang,Y*., Östling, P*., Åkerfelt, M., Trouillet, D., Rallu, M., Gitton, Y., El Fatimy, R., Fardeau, V., Le Crom, S., Morange, M., Sistonen, L. & Mezger, V. (2006). Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression. Genes Dev., 20:836-847.
Cao, J., Viholainen, J.I., Dart, C., Warwick, H.K., Leyland, M.L. and Courtney, M.J. (2005) The nNOS-PSD95 interface - a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J. Cell Biol. 168, 117-126.
Mattila E., Pellinen, T., Nevo, J., Vuoriluoto, K. Arjonen, A. and Ivaska, J (2005) Negative regulation of EGFR signalling via integrin a1b1-mediated activation of protein tyrosine phosphatase TCPTP. Nature Cell Biol. 7:78-85.
Ivaska, J., Vuoriluoto, K., Huovinen, T., Izawa, I., Inagiki, K., and Parker, PJ. (2005) PKCe mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J. 24:3834-3845.
Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol. 2005,15:1078-89.
Skotheim RI, Lind GE, Monni O, Nesland JM, Abeler VM, Fossa SD, Duale N, Brunborg G, Kallioniemi O, Andrews PW, Lothe RA. Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. Cancer Res. 2005 Jul 1;65(13):5588-98.
Technau, U., Rudd, S., Maxwell, P., Gordon, P.M.K., Saina, M., Grasso, L.C., Hayward, D.C., Sensen, C.W., Saint, R., Holstein, T.W., Ball, E.E. & Miller, D.J. (2005). Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians. Trends Genet. 21:633-639.
Laitinen, R., Immanen, J., Auvinen, P., Rudd, S., Alatalo, A., Paulin, L., Ainasoja, M., Kotilainen, M., Koskela, S., Teeri, T.H. & Elomaa, P. (2005). Analysis of the floral transcriptome uncovers new regulators of organ determination and gene families related to flower organ differentiation in Gerbera hybrida (Asteraceae). Genome Research 15:475-486.
Tran, S.E.F., Meinander, A. & Eriksson, J.E. (2004). Instant decisions: transcription-independent control of death-receptor-mediated apoptosis. Trends Biochem. Sci. 29:601-608.
Kallioniemi O. Profile of a tumour. Nature. 428: 379-382, 2004.
Hutter, R., Valdiviezo, C., Sauter, B.V., Savontaus, M., Chereshnev, I., Carrick, F.E., Bauriedel, G., L?deritz, B., Fallon, J.T., Fuster, V. & Badimon, J.J. (2004). Caspase-3 and tissue factor expression in lipid-rich plaque macrophages. Circulation 109:2001-2008.
McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol. 2004,14:131-7.
Huusko P, Ponciano-Jackson D, Wolf M, Kiefer JA, Azorsa DO, Tuzmen S, Weaver D, Robbins C, Moses T, Allinen M, Hautaniemi S, Chen Y, Elkahloun A, Basik M, Bova GS, Bubendorf L, Lugli A, Sauter G, Schleutker J, Ozcelik H, Elowe S, Pawson T, Trent JM, Carpten JD, Kallioniemi OP, Mousses S. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet. 2004 Aug 8 [Epub]
Peltola, K.J., Paukku, K., Aho, T.L.T., Ruuska, M., Silvennoinen, O. & Koskinen, P.J. (2004). Pim-1 kinase inhibits Stat5-dependent transcription via its interactions with SOCS1 and SOCS3. Blood 103:3744-3750.
Sandqvist, A. & Sistonen, L. (2004). Nuclear stress granules: the awakening of a sleeping beauty? J. Cell Biol. 164:15-17.
Papageorgiou, A.C. & Wikman, L. (2004). Is JAK3 a new drug target for immunomodulation-based therapies? Trends Pharmacol. Sci. 25:558-562.
Lai, J., Dey, N., Kim, C.-S., Bharti, A., Rudd, S., Mayer, K.F.X., Larkins, B., Becraft, P. & Messing, J. (2004). Characterization of the maize endosperm transcriptome and its comparison to the rice genome. Genome Research 10A:1932-1937.