Turku Centre for Biotechnology

Turun Biotekniikan Keskus          Åbo Bioteknikcentrum

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Molecular and Systems Immunology and Stem Cell Biology

Contact Information

Molecular Immunology Group
Turku Centre for Biotechnology
P.O. Box 123, BioCity
(Street adr. Tykistökatu 6 B)
FIN-20521 Turku, Finland
+358-2-333 8601 (Riitta Lahesmaa)
+358-40-718 4813 (Mobile)
+358-2-333 8011 (Laboratory)
+358-2-333 8000 (fax)

Projects

Type 1 Diabetes

Th Cell Differentiation

Stem Cells

Group Members

Funding

The Academy of Finland, National Technology Agency of Finland (TEKES), Sigrid Jusélius Foundation, The Finnish Cancer Organizations, JDRF, EU FP6 (ESTOOLS), http://www.estools.eu/, Turku University Hospital Fund, Graduate Schools (TuBS, DDGS, ISB), University of Turku, Åbo Akademi University, EUFP7 EraSysBioPlus, SYBILLA, http://www.sybilla-t-cell.de , NANOMMUNE, DIABIMMUNE, http://www.diabimmune.org

Key Collaborations

Aebersol Ruedi, ETHZ, Zürich, Switzerland
Aittokallio Tero, University of Turku 
Alenius Harri, Finnish Institute of Occupational Health, Helsinki
Andrews Peter, University of Sheffield, UK
Autio Reija, Tampere University of Technology
Burge Christopher, MIT, Cambridge, USA
Fadeel Bengt, Karolinska Institute, Stockholm, Sweden
Galande Sanjeev, National Centre for Cell Science, NCCS, Pune, India
Goodlett David, University of Washington, USA
Gstaiger Matthias, ETHZ, Zürich, Switzerland
Hawkins David, Turku Centre for Biotechnology
Hovatta Outi, Karolinska Institute, Stockholm, Sweden
Hyöty Heikki, University of Tampere
Ilonen Jorma, University of Turku 
Jaakkola Panu, Turku Centre for Biotechnology
Kere Juha, Karolinska Institute, Stockholm, Sweden
Knip Mikael, University of Helsinki
Lähdesmäki Harri, Tampere University of Technology and Aalto University
Nevalainen Olli, University of Turku
Oresic Matej, VTT Technical Research Centre of Finland, Turku
Otonkoski Timo, University of Helsinki
Rao Anjana, Immune Disease Institute, Harvard Medical School, Boston, USA
Rao Kanury, ICGEB, Delhi, India
Ren Bing, Ludwig Institute for Cancer Research, University of California, San Diego, USA
Simell Olli, University of Turku
Stockinger Brigitta, NIMR, London, UK
Tushl Thomas, Rockefeller University, New York, USA
Yli-Harja Olli, Tampere University of Technology

Selected Publications

Tuomela S, Salo V, Tripathi SK, Chen Z, Laurila K, Gupta B, Äijö T,
Oikari L, Stockinger B, Lähdesmäki H, Lahesmaa R. Identification of early gene expression changes during human Th17 cell differentiation. (2012) Blood [Epub ahead of print]

Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R. RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. (2011) Stem Cells 30(3):452-60

Tripathi P, Sahoo N, Ullah U, Kallionpää H, Suneja A, Lahesmaa R, Rao KVS. (2011) MAP kinase initiates digital regimens of signal sensing to control specificity and amplitude of human Th2 cell differentiation. Immunol Cell Biol. doi: 10.1038/icb.2011/87 [Epub ahead of print]

O'Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y. Genomic views of STAT function in CD4(+) T helper cell differentiation. (2011) Nature Reviews Immunology, 11:239-250

Hussein S, Batada N, Vuoristo S, Ching R, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, Bazett-Jones D, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T. Copy number variation and selection during reprogramming to pluripotency. (2011) Nature, 471:58-62

Koh KP, Yabuuchi A, Rao S, Cunniff K, Laiho A, Tahiliani M, Huang Y, Thompson E, Nardone J, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SO, Rodig SJ, Daley GQ, Rao A. Tet1 and related 5-methylcytocine hydroxylases modulate pluripotency and cell lineage specification in mouse embryonic stem cells. (2011) Cell Stem Cell, 8:200-213

Elo LL, Järvenpää H, Tuomela S, Raghav S, Ahlfors H, Laurila K, Gupta B, Lund RJ, Tahvanainen J, Hawkins RD, Oresic M, Lähdesmäki H, Rasool O, Rao KV, Aittokallio T, Lahesmaa R. Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity. 2010 32:852-62

Ahlfors H, Limaye A, Elo-Uhlgrén L, Notani D, Gottimukkala K, Burute M, Tuomela S, Rasool O, Galande S* & Lahesmaa R*.  SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation. Submitted. *Equal contribution. Blood. 2010 116:1443-53.

Moulder R*, Lönnberg T*, Filén J-J, Elo L, Rainio E, Corthals G, Oresic M, Nyman TA, Aittokallio T, Lahesmaa R (*equal contribution). Quantitative Proteomics Analysis of the Nuclear Fraction of Human CD4+ Cells in the Early Phases of IL-4 Induced Th2 Differentiation. Molecular Cellular Proteomics. 2010 9:1937-53.

Närvä E, Autio R, Rahkonen N, Kong L, Harrison N, Kitsberg D, Borghese L, Itskovitz-Eldor J, Rasool O, Dvorak P, Hovatta O, Otonkoski T, Tuuri T, Cui W, Brüstle O, Baker D, Maltby E, Moore HD, Benvenisty N, Andrews PW, Yli-Harja O, Lahesmaa R. High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nature Biotechnology. 2010 28:371-379.

Filén S, Ylikoski E, Tripathi S, West A, Björkman M, Nyström J, Ahlfors H, Coffey E, Rao KV, Rasool O, Lahesmaa R. Activating transcription factor 3 is a positive regulator of human IFNG gene expression. J Immunol. 2010 May 1;184(9):4990-9. Epub 2010 Mar 19.

Cho SH, Goenka S, Henttinen T, Gudapati P, Reinikainen A, Lahesmaa R, Boothby M. PARP-14, a member of the B aggressive lymphoma (BAL) family, transduces survival signals in primary B cells. Blood. 2009 Mar 12;113(11):2416-25. Epub 2009 Jan 15.

Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R. Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling. J Autoimmun. 2010 Mar 29. [Epub ahead of print]

Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med. 2008 Dec 22;205(13):2975-84. Epub 2008 Dec 15.

Rautajoki K, Tuomela S, Moulder R, Nyman T, Lahesmaa R. Identification of novel Stat6 regulated proteins in IL-4 treated mouse lymphocytes. Proteomics. 2009 Feb;9(4):1087-98.

Tahvanainen J, Kallonen T, Lähteenmäki H, Heiskanen K, Westermarck J, Rao KV and Lahesmaa R. PRELI is a mitochondrial regulator of human primary T helper cell apoptosis, STAT6 and Th2 cell differentiation. Blood, Oct 22. (Epub ahead of printing)

Filén JJ, Filén S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Björkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R. Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation. Mol Cell Proteomics. 2008 Aug 12. (Epub ahead of printing)

Kumar D, Srikanth R, Ahlfors H, Lahesmaa R, Rao KV. Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response. Molecular Systems Biology, 2007:3:150. 

Lund RJ*, Loytomaki M*, Naumanen T, Dixon C, Chen Z, Ahlfors H, Tuomela S, Tahvanainen J, Scheinin J, Henttinen T, Rasool O, Lahesmaa R. Genome Wide Identification of Novel Genes Involved in Early Th1 and Th2 Cell Differentiation. J Immunol. 2007Mar 15;178(6):3648-60. *Equal contribution

Rautajoki KJ, Marttila EM, Nyman TA, Lahesmaa R.  IL-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human Th2 cell differentiation. Mol Cell Proteomics. 2007 Feb;6(2):238-251. Epub 2006 Nov 17.

Hahtola S, Tuomela S, Elo L, Hakkinen T, Karenko L, Nedoszytko B, Heikkila H, Saarialho-Kere U, Roszkiewicz J, Aittokallio T, Lahesmaa R, Ranki A. Th1 response and cytotoxicity genes are down-regulated in cutaneous T-cell lymphoma. Clin Cancer Res. 2006, 12(16):4812-21.

Tahvanainen J, Pykalainen M, Kallonen T, Lahteenmaki H, Rasool O, Lahesmaa R. Enrichment of nucleofected primary human CD4+ T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation. J Immunol Meth 2006, 310(1-2):30-9.

Pykäläinen M, Kinos R, Valkonen S, Rydman P, Kilpeläinen M,  Laitinen LA, Karjalainen J, Nieminen M, Hurme M, Kere J, Laitinen T, Lahesmaa R. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol. 2005 115:80-7.

Skottman H, Mikkola M, Lundin K, Olsson C, Strömberg A-M, Tuuri T, Otonkoski T, Hovatta O, Lahesmaa R. Gene expression signatures of seven individual human embryonic stem cell lines. Stem Cells 2005, 23 (9):1343-56.

Lund R, Chen Z, Scheinin J, Lahesmaa, R. Early target genes of IL-12/STAT4 signaling in T helper cells. J. Immunol., 2004;  172:6775-82.

Lund, R, Aittokallio, T, Nevalainen, O and Lahesmaa, R. Identification of novel genes regulated by IL-12, IL-4 and TGFb during the early polarization of CD4+ lymphocytes. J. Immunol., 2003, 171:5328-5336.

Chen Z, Lund R, Aittokallio T, Kosonen M, Nevalainen O, Lahesmaa R. Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol., 2003, 171:3627-3635.

Hamalainen H, Zhou H, Chou W, Hashizume H, Heller R, Lahesmaa R. Distinct gene expression profiles of human type 1 and type 2 T helper cells.
Genome Biol. 2001;2(7):RESEARCH0022.

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