Westermarck J.Phosphatases catching up with the level of knowledge; finally druggable? ScienceDirect. 2018. Link to text
Lund RJ et al. DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer. Sci Rep. 2017. Pubmed
Nguyen EV et al. Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells. Mol Cell Proteomics 16. 2017. Pubmed
Peuhu E et al. Epithelial vimentin plays a functional role in mammary gland development. Development 144. 2017. Link to text
Peuhu E et al. Integrin beta1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice. Plos One. 2017. Link to text
Li Z et al. AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis. Brain Behav Immun. 62. 2017. Pubmed
Haataja S et al. Rationally designed chemically modified glycodendrimer inhibits Streptococcus suis adhesin SadP at picomolar concentrations. Chemistry [Epub ahead of print]. 2017. Pubmed
Liu Y et al. PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. Dev Cell. 2017. Pubmed
Kaukonen R et al. Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment. Nature Protocols 12. 2017. Link to text
Sents W et al. PP2A inactivation mediated by PPP2R4 haploinsufficiency promotes cancer development. Cancer Res. 2017. Pubmed
Lindqvist J et al. Nestin contributes to skeletal muscle homeostasis and regeneration. J. Cell Sci. 2017. Pubmed
Gullmets J et al. Internal epithelia in Drosophila display rudimentary competence to form cytoplasmic networks of transgenic human vimentin. FASEB J. 2017. Pubmed
Cheng F, Eriksson JE. Intermediate Filaments and the Regulation of Cell Motility during Regeneration and Wound Healing. Cold Spring Harb Perspect Biol. 2017. Pubmed
Tanaka T N et al. Whole-tissue biopsy phenotyping of three-dimensional tumours reveals cancer heterogeneity. Nature Biomedical Engineering. 2017. Link to text
Mauretti A et al. Spheroid 3D culture and hypoxia activate Notch signaling in cardiac progenitor cells MRS Communication. 2017.
Sahlgren C et al. Tailored approaches in drug development and diagnostics ? from molecular design to biological model systems. Advanced Health Care Materials. 2017
Seyednasrollah F et al. A DREAM Challenge to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer. JCO Clinical Cancer Informatics, no. 1 (September 2017) 1-15.
Posada IMD et al. Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1. Sci Rep. 2017.
Pasumarthy KP et al. Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements. Stem Cell Rep. 2017. Link to text
Anniina Vihervaara et al. Transcriptional response to stress is pre-wired by promoter and enhancer architecture. Nature Communications, 2017. Pubmed
Ilkka Paatero et al. Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes. Scientific Reports 2017. Link to Text
Valensisi C et al. Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases. Cell Rep. 2017.
Rautakorpi LK et al. End-of-life chemotherapy use at a Finnish university hospital: a retrospective cohort study. Acta Oncol. 2017.
Välikangas T et al. A comprehensive evaluation of popular proteomics software workflows for label-free proteome quantification and imputation. Brief Bioinform. 2017.
Suomi T et al. ROTS: An R package for reproducibility-optimized statistical testing. PLOS Computational Biology 2017.Link to text
Rautakorpi LK et al. Assessing the utilization of radiotherapy near end of life at a Finnish University Hospital: a retrospective cohort study. Acta Oncol. 2017.
Fatemeh Seyednasrollah et al. How Reliable are Trial-based Prognostic Models in Real-world Patients with Metastatic Castration-resistant Prostate Cancer? European Urology, Feb 8, 2017.
Seyednasrollah F et al. Prediction of adulthood obesity using genetic and childhood clinical risk factors in the Cardiovascular Risk in Young Finns Study. To appear in Circ Cardiovasc Genet.
Meraj H. Khan et al. The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex. J Cell Sci 2017. Link to tex
Perveen S et al. Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique dimeric structure. FEBS Open Bio. 2017. Pubmed
Jacquemet G et al. FiloQuant reveals increased filopodia density during breast cancer progression. J Cell Biol. 2017. Link to text
Melero-Fernandez de Mera RM et al. A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs. Nat. Commun. 2017 Link to text
Daniel Antfolk, Marika Sjöqvist, Fang Chenga, Kimmo Isoniemi Camille L. Duran, Adolfo Rivero-Muller, Christian Antila, Rasmus Niemi Sebastian Landor, Carlijn V. C. Bouten, Kayla J. Bayless, John E. Eriksson, and Cecilia M. Sahlgren. Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. PNAS Early Edition, pnas.1703057114. Pubmed
Lund R, Rahkonen N, Malonzo M, Kauko L, Emani MR, Kivinen V, Närvä E, Kemppainen E, Laiho A, Skottman H, Hovatta O, Rasool O, Nykter M, Lähdesmäki H, Lahesmaa R. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Stem Cell Rep. 09 May, 2017. Link to text
Papageorgiou AC, Chen J, Li D. Crystal structure and biological implications of a glycoside hydrolase family 55 β-1,3-glucanase from Chaetomium thermophilum. Biochim Biophys Acta. 2017 May 4. Epub ahead of print. Pubmed
Li LL, Cisek K, Courtney MJ. Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element. Front. Mol. Neurosci. 10:58. Link to full text, PMID
von Ossowski L, Li LL, Möykkynen T, Coleman SK, Courtney MJ, Keinänen K. Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors. PLoS One. Feb 2;12(2):e0171489. Link to full text, PMID
Lund RJ, Huhtinen K, Salmi J, Rantala J, Nguyen EV, Moulder R, Goodlett DR, Lahesmaa R, Carpén O. DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer. Sci Rep. 04 May 2017. Link
Marek A. Budzynski, Tim Crul, Samu Himanen, Noemi Toth, Ferenc Otvos, Lea Sistonen, Laszlo Vigh. Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility. Cell Stress and Chaperones. First Online: 04 May 2017. Link
Marek A. Budzynski and Lea Sistonen. Versatile Functions of Heat Shock Factors: It is Not All About Stress. Current Immunology Reviews. E-pub Ahead of Print. Link
Iris A K Lähdeniemi, Julia O Misiorek, Christian J M Antila, Sebastian K-J Landor, Carl-Gustaf A Stenvall, Lina E Fortelius, Linda K Bergström, Cecilia Sahlgren and Diana M Toivola. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death & Differentiation, 5 May 2017, Advance online publication. Link
Chatzikonstantinou M, Vlachakis D, Chronopoulou E, Papageorgiou L, Papageorgiou AC, Labrou NE. 2017. The glutathione transferase family of Chlamydomonas reinhardtii : Identification and characterization of novel sigma class-like enzymes. Algal Research 24, 237–250. Link
Kellici TF, Mavromoustakos T, Jendrossek D, Papageorgiou AC. Crystal structure analysis, covalent docking and molecular dynamics calculations reveal a conformational switch in PhaZ7 PHB depolymerase. Proteins. 2017 [Epub ahead of print] Pubmed
Maria Georgiadou, Johanna Lilja, Guillaume Jacquemet, Camilo Guzmán, Maria Rafaeva, Charlotte Alibert, Yan Yan, Pranshu Sahgal, Martina Lerche, Jean‑Baptiste Manneville, Tomi P. Mäkelä and Johanna Ivaska. AMPK negatively regulates tensin-dependent integrin activity. Journal of Cell Biology. Published online 13th March 2017. Pubmed