The Protein Crystallography Core Facility assists investigators in the determination of the 3-D structure of biological macromolecules and their complexes. The Facility utilizes state-of-the-art technology to understand the structural basis of biological function.
has been installed
have arrived for use in thermal shift assays
now available in our facility
new material on integrative structural biology added
Our core facility is part of the Structural Biology Infrastructure Network...details
X-ray crystallography is the major method for structure determination of macromolecules. About 85% of all known structures deposited in the Protein Data Bank have been determined by X-ray crystallography. Knowing the structure of a protein helps in understanding better how the protein works, how it interacts with other proteins and small molecules in the cell and what kind of conformational changes it undergoes to exert its function. Even subtle changes in protein structures can have tremendous consequences on human health, causing serious diseases. A major application therefore of X-ray crystallography is in the design of new drugs.
A crystal structure determination is not a trivial task. It mainly involves five steps with the first two being the most difficult ("bottlenecks"):
The Facility has long expertise in all these steps and we are able to undertake projects from Academic groups and companies, either as a collaborative effort or as a service.
combined with the Finnish Synchrotron Radiation Users Organization (FSRUO) meeting, Turku, December 4-5 ...details soon
regarding the International Year of Crystallography...details
We offer training and learning modules for every step of the crystal structure determination process, from simple to challenging cases.