News

Crystal imager

has been installed

New screens for protein stability

have arrived for use in thermal shift assays

LCP kit for membrane crystallization

now available in our facility

Course on X-ray crystallography techniques (4 ects)

new material on integrative structural biology added

Unipucks for Diamond Light Source (UK) available in our facility....

recently purchased...details

Member of Biocenter Finland

Our core facility is part of the Structural Biology Infrastructure Network...details

Crystallography

X-ray crystallography is the major method for structure determination of macromolecules. About 85% of all known structures deposited in the Protein Data Bank have been determined by X-ray crystallography. Knowing the structure of a protein helps in understanding better how the protein works, how it interacts with other proteins and small molecules in the cell and what kind of conformational changes it undergoes to exert its function. Even subtle changes in protein structures can have tremendous consequences on human health, causing serious diseases. A major application therefore of X-ray crystallography is in the design of new drugs.

A crystal structure determination is not a trivial task. It mainly involves five steps with the first two being the most difficult ("bottlenecks"):

  • Protein purification
  • Crystallisation
  • Data collection and processing
  • Determination of the phases ('the phase problem')
  • Model building, refinement and analysis

The Facility has long expertise in all these steps and we are able to undertake projects from Academic groups and companies, either as a collaborative effort or as a service. 

 

 

Education

Structural biology courses in Finland

as part of the Finnish-INSTRUCT NAC...details

INSTRUCT training courses

...details

Next FINNBOX meeting

combined with the Finnish Synchrotron Radiation Users Organization (FSRUO) meeting, Turku, December 4-5 ...details soon

Crystallography matters! A leaflet from IUCR

regarding the International Year of Crystallography...details

Learn or train in crystallography?

We offer training and learning modules for every step of the crystal structure determination process, from simple to challenging cases.