Melero-Fernandez de Mera RM*, Li LL*, Popinigis A, Cisek K, Tuittila M, Yadav L, Serva A, Courtney MJ (2017) A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs. *equal contribution. Nat. Commun. 8, 15017. Link to text    Pubmed

Daniel Antfolk, Marika Sjöqvist, Fang Chenga, Kimmo Isoniemi Camille L. Duran, Adolfo Rivero-Muller, Christian Antila, Rasmus Niemi Sebastian Landor, Carlijn V. C. Bouten, Kayla J. Bayless, John E. Eriksson, and Cecilia M. Sahlgren. Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. PNAS      Early Edition, pnas.1703057114. Pubmed

Lund R, Rahkonen N, Malonzo M, Kauko L, Emani MR, Kivinen V, Närvä E, Kemppainen E, Laiho A, Skottman H, Hovatta O, Rasool O, Nykter M, Lähdesmäki H, Lahesmaa R. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Stem Cell Rep. 09 May, 2017. Link to text

Papageorgiou AC, Chen J, Li D. Crystal structure and biological implications of a glycoside hydrolase family 55 β-1,3-glucanase from Chaetomium thermophilum. Biochim Biophys Acta. 2017 May 4. Epub ahead of print. Pubmed

Li LL, Cisek K, Courtney MJ. Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element. Front. Mol. Neurosci. 10:58. Link to full textPMID

von Ossowski L, Li LL, Möykkynen T, Coleman SK, Courtney MJ, Keinänen K. Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors. PLoS One. Feb 2;12(2):e0171489. Link to full text,  PMID

Lund RJ, Huhtinen K, Salmi J, Rantala J, Nguyen EV, Moulder R, Goodlett DR, Lahesmaa R, Carpén O. DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer. Sci Rep. 04 May 2017. Link

Marek A. Budzynski, Tim Crul, Samu Himanen, Noemi Toth, Ferenc Otvos, Lea Sistonen, Laszlo Vigh. Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility. Cell Stress and Chaperones. First Online: 04 May 2017. Link

Marek A. Budzynski and Lea Sistonen. Versatile Functions of Heat Shock Factors: It is Not All About Stress. Current Immunology Reviews. E-pub Ahead of Print. Link

Iris A K Lähdeniemi, Julia O Misiorek, Christian J M Antila, Sebastian K-J Landor, Carl-Gustaf A Stenvall, Lina E Fortelius, Linda K Bergström, Cecilia Sahlgren and Diana M Toivola. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death & Differentiation, 5 May 2017, Advance online publication. Link

Chatzikonstantinou M, Vlachakis D, Chronopoulou E, Papageorgiou L, Papageorgiou AC, Labrou NE. 2017. The glutathione transferase family of Chlamydomonas reinhardtii : Identification and characterization of novel sigma class-like enzymes. Algal Research 24, 237–250. Link

Kellici TF, Mavromoustakos T, Jendrossek D, Papageorgiou AC. Crystal structure analysis, covalent docking and molecular dynamics calculations reveal a conformational switch in PhaZ7 PHB depolymerase. Proteins. 2017  [Epub ahead of print] Pubmed

Maria Georgiadou, Johanna Lilja, Guillaume Jacquemet, Camilo Guzmán, Maria Rafaeva, Charlotte Alibert, Yan Yan, Pranshu Sahgal, Martina Lerche, Jean‑Baptiste Manneville, Tomi P. Mäkelä and Johanna Ivaska. AMPK negatively regulates tensin-dependent integrin activity. Journal of Cell Biology. Published online 13th March 2017. Pubmed

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We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network providing services for local as well as national and international scientists.

Drop by anytime to learn how TCB can advance your research in ways previously unforeseen!


09.06.2017 13:15

Academy of Finland awarded Guillaume Jacquemet (Ivaska lab) with Academy Postdoctoral Fellow funding 259 054 € for 2017-2020

Academy of Finland awarded Guillaume Jacquemet (Ivaska lab) with Academy Postdoctoral Fellow...

02.06.2017 10:50

Academy of Finland awarded Maria Georgiadou (Ivaska lab) with Academy Postdoctoral Fellow funding 261 109 € for 2017-2020

Academy of Finland awarded Maria Georgiadou (Ivaska lab) with Academy Postdoctoral Fellow funding...

30.05.2017 12:19

Researchers invented a tools to decode and control signalling circuits in living cells with flashes of light

Researchers at the Turku Centre for Biotechnology have invented new tools to decode and control...

TCB presents

Core facility of the month - Bioinformatics Unit