Instrumentation

Instrumentation for protein identification and quantification involves several ESI-MS/MS devices.

Mass spectrometers:

 

  • Q Exactive HF

    ESI-hybrid quadrupole-orbitrap (Thermo Scientific)

 

  • Q Exactive

    ESI-hybrid quadrupole-orbitrap (Thermo Scientific)

    Used for protein quantitation and PTM analysis.

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  • TSQ Vantage

    ESI-triple stage quadrupole (Thermo Scientific)

    Used for targeted protein quantitation (SRM).

 

  • LTQ Orbitrap Velos Pro

    with ETD, ESI-hybrid ion trap-orbitrap (Thermo Scientific)

    Used for protein identification, quantitation, PTM analysis and structural studies.

     

Pressure Cycling Technology sample preparation System:

  • Barocycler

    Barocycler is a sample preparation instrument working with pressure cycling technology. For rapid and reproducible extraction of proteins from a wide variety of cells and tissues, particularly those considered “hard-to-lyse”.

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    Application:
    • Guo et al. Nature medicine 2015 [PubMed]