List of publications

2017

Kaukonen R, Jacquemet G, Hamidi H, Ivaska J (2017) Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment.  Nat Protoc 12(11):2376-2390

Peuhu E, Virtakoivu R, Mai A, Wärri A, Ivaska J (2017) Epithelial vimentin plays a functional role in mammary gland development. Development  [Epub ahead of print]

Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J (2017) FiloQuant reveals increased filopodia density during breast cancer progression. J Cell Biol 216(10): 3387-3403

Georgiadou M, Ivaska J (2017) Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation. Trends Cell Biol pii: S0962-8924(17)30103-4

Närvä E, Stubb A, Guzmán C, Blomqvist M, Balboa D, Lerche M, Saari M, Otonkoski T, Ivaska J (2017) A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion. Stem Cell Reports 9(1):67-76

Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J (2017) AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol 216(4):1107-1121

Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J (2017) SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nat Cell Biol 19(4):292-305

Peuhu E, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attieh Y, Silva KA, Betz T, Sundberg JP, Salmi M, Deugnier MA, Eliceiri KW, Ivaska J (2017) SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. EMBO J 36(2):165-182

Hamidi H, Ivaska J (2017) Vascular Morphogenesis: An Integrin and Fibronectin Highway. Curr Biol 27(4):R158-R161

2016

Jacquemet G, Baghirov H, Georgiadou M, Sihto H, Peuhu E, Cettour-Janet P, He T, Perälä M, Kronqvist P, Joensuu H, Ivaska J (2016) L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nat Commun 7:13297

Hamidi H, Pietilä M, Ivaska J (2016) The complexity of integrins in cancer and new scopes for therapeutic targeting. Br J Cancer 115:1017-1023

Rantakari P, Jäppinen N, Lokka E, Mokkala E, Gerke H, Peuhu E, Ivaska J, Elima K, Auvinen K, Salmi M (2016) Fetal liver endothelium regulates the seeding of tissue-resident macrophages.  Nature 538:392-396

Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J (2016) Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.  Nat Commun 7:12237.

Cheng F, Shen Y, Mohanasundaram P, Lindström M, Ivaska J, Ny T, Eriksson JE (2016) Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β-Slug signaling. Proc Natl Acad Sci U S A 113(30):E4320-7

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robert-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J, Kermorgant S (2016) Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun  7:11942.

Ratcliffe CD, Sahgal P, Parachoniak CA, Ivaska J, Park M (2016) Regulation of cell migration and β1 integrin trafficking by the endosomal adaptor GGA3. Traffic 17:670-688

De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel AG, Wilson TA, Pouwels J, Montagnac G, Owen DJ, Ivaska J (2016) Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nat Struct Mol Biol23(2):172-9.

Alanko J, Ivaska J (2016) Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling. Trends Cell Biol 26(6):391-8

2015

De Franceschi N, Peuhu E, Parsons M, Rissanen S, Vattulainen I, Salmi M, Ivaska J, Pouwels J (2015) Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. PLoS One 10(11):e0143423

Alanko J, Mai A, Jacquemet G, Schauer K, Kaukonen R, Saari M, Goud B, Ivaska J (2015) Integrin endosomal signalling suppresses anoikis. Nat Cell Biol 17(11):1412-21

Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015) Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCαDev Cell 34(4):475-83

Jacquemet G, Hamidi H, Ivaska J (2015) Filopodia in cell adhesion, 3D migration and cancer cell invasion. Curr Opin Cell Biol 36:23-31

Virtakoivu R, Mai A, Mattila E, De Franceschi N, Imanishi SY, Corthals G, Kaukonen R, Saari M, Cheng F, Torvaldson E, Kosma VM, Mannermaa A, Muharram G, Gilles C, Eriksson J, Soini Y, Lorens JB, Ivaska J (2015) Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function. Cancer Res 75(11):2349-62

De Franceschi N, Hamidi H, Alanko J, Sahgal P, Ivaska J (2015) Interin traffic – the update. J Cell Sci 128(5):839-52

Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P (2015) Endothelial destabilization by angiopoietin-2 via integrin b1 activation. Nat Commun 30;6:5962

Weber-Boyvat M, Kentala H, Lilja J, Vihervaara T, Hanninen R, Zhou Y, Peränen J, Nyman TA, Ivaska J, Olkkonen VM (2014) OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Exp Cell Res pii: S0014-4827(14)00480-7

2014

Muharram G, Sahgal P, Korpela T, De Franceschi N, Kaukonen R, Clark K, Tulasne D, Carpén O, Ivaska J (2014) Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells.  Dev Cell  29(4):421-36

Mai A, Muharram G, Barrow-McGee R, Baghirov H, Rantala J, Kermorgant S, Ivaska J (2014) Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1.  J Cell Sci 127(Pt 9):1938-52

Eskova A, Knapp B, Matelska D, Reusing S, Arjonen A, Lisauskas T, Pepperkok R, Russell R, Eils R, Ivaska J, Kaderali L, Erfle H, Starkuviene V (2014) RNAi screen identifies KIF15 as a novel regulator of integrin endocytic trafficking.  J Cell Sci 127(Pt 11):2433-47

Arjonen A, Kaukonen R, Mattila E,  Rouhi P, Högnäs G, Sihto H, Miller BW, Morton JP, Bucher E, Taimen P, Virtakoivu R, Cao Y, Sansom OJ, Joensuu H, Ivaska J (2014) Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.  J Clin Invest  24(3):1069–1082

2013

Pouwels J, De Franceschi N. Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg J, Hogg N, Gahmberg CG, Salmi M, Ivaska J (2013) SHARPIN regulates uropod detachment in migrating lymphocytes. Cell Rep 5:619-28

Ylilauri M, Mattila E, Nurminen EM, Käpylä J, Niinivehmas SP, Määttä JA, Pentikäinen U, Ivaska J, Pentikäinen OT (2013) Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone. Biochim Biophys Acta 1834:1988-97

Högnäs G, Tuomi S, Mattil E, Laine JO, Vilkki V, Murumägi A, Edgren H, Kallioniemi O and Ivaska, J (2013) Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation. Carcinogenesis 9:2000-2009

Costa P, Scales TM, Ivaska J, Parsons M. (2013) Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion. PLoS One 8(9):e74659

Hämälistö S, Pouwels J, de Franceschi N, Saari M, Ivarsson Y, Zimmermann P, Brech A, Stenmark H and Ivaska J (2013) A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin. PLOS one 8(8):e70696

Bouvard D, Pouwels J, De Franceschi N. and Ivaska J. (2013) Integrin inactivators: balancing cellular functions in vitro and in vivo. Nat Rev Mol Cell Biol 14:430-442

Westermarck J, Ivaska J and Corthals GL. (2013) Identification of Protein Interactions Involved in Cellular Signalling. Mol Cell Proteomics 12(7):1752-1763

2012

Högnäs G, Tuomi S, Veltel S, Mattila E, Murumägi A, Edgren H, Kallioniemi O and Ivaska J (2012) Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivoOncogene 31:3597-3606

Arjonen A, Alanko J, Veltel S, Ivaska J (2012) Distinct Recycling of Active and Inactive β1 Integrins. Traffic 13:610-25 

Rintanen N, Karjalainen M, Alanko J, Paavolainen L, Mäki A, Nissinen L, Lehkonen M, Kallio K, Cheng RH, Upla P, Ivaska J and Marjomäki V (2012) Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway. Mol Biol Cell 23:448-463

Pellinen T, Rantala JK, Arjonen A, Mpindi JP, Kallioniemi O and Ivaska J (2012) A functional genetic screen reveals new regulators of β1-integrin activity. J Cell Sci 125:649-661

Virtakoivu R, Pellinen T, Rantala JK, Perälä M and Ivaska J (2012) Distinct roles of AKT isoforms in regulating β1-integrin activity, migration and invasion in prostate cancer. Mol Biol Cell 17:3357-3369

Sandri C, Caccavari F, Valdembri D, Camillo C, Veltel S, Santambrogio M, Lanzetti L, Bussolino F, Ivaska J, Serini G (2012) The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res 10:1479-1501

Ivaska J (2012) Unanchoring integrins in focal adhesions. Nat Cell Biol 14:981-983 (Invited commentary)

Pouwels J, Nevo J, Pellinen T, Ylänne J and Ivaska J (2012) Negative regulators of integrin activity. J Cell Sci 125:3271-3280

2011

Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi JP, Nevo J, Gjerdrum C, Lorens JB and Ivaska J (2011) Vimentin regulates EMT induction and migration by governing Axl expression in breast cancer. Oncogene 30:1436-1448

Vuoriluoto K, Högnäs G, Meller P, Lahti K and Ivaska J (2011) Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP. Matrix Biology 30:207-217

Mai A, Veltel S, Pellinen T, Padzik A, Coffey E, Marjomäki V and Ivaska J (2011) Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor trafficking in migrating cancer cells. J Cell Biol 194:291-306

Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Potter C, Duffy T, Sundberg JP, Askari JA, Humphries M, Kallioniemi O, Parsons M, Salmi M. and Ivaska J (2011) Sharpin is an endogenous inhibitor of beta1-integrin activation. Nat Cell Biol 13:1315-1324

Arjonen A, Kaukonen R and Ivaska J (2011) Filopodia and adhesion in cancer cell motility. Cell Adh Migr 5:421-430

Ivaska J. and  Heino J (2011) Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis. Annu Rev Cell Dev Biol 27:291-320

Ivaska J (2011) Vimentin – central hub in EMT induction? Small GTPasesSmall GTPases 2:51-54

Mattila E, Ivaska J (2011) High-Throughput Methods in Identification of Protein Tyrosine Phosphatase Inhibitors and Activators. Anticancer Agents Med Chem 2011 11:141-150

2010

Mattila E, Marttila H, Sahlberg N, Kohonen P, Tahtinen S, Halonen P, Perala M, Ivaska J (2010) Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase. BMC Cancer 10(1):7

Vihinen PP, Hernberg M, Vuoristo MS, Tyynelä K, Laukka M, Lundin J, Ivaska J, Pyrhönen S. (2010) A phase II trial of bevacizumab with dacarbazine and daily low-dose interferon-alpha2a as first line treatment in metastatic melanoma. Melanoma Res 20:318-25

Nevo J, Mai A, Tuomi S, Pellinen T, Pentikäinen OT, Heikkilä P, Lundin J, Joensuu H, Bono P. and Ivaska J (2010) Mammary derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion. Oncogene 29:6452-63 

Plantard, L. Arjonen, A, Lock, J.G, Nurani, G, Ivaska J and Strömblad S (2010) PtdIns(3,4,5)P3 is a regulator of Myosin-X localization and filopodia formation. J. Cell Sci 123:3525-34

Ivaska J, and Heino J (2010) Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes. Cell Tissue Res 339:111-120

2009

Tuomi S, Mai A, Nevo J, Laine JO, Vilkki V, Öhman TJ, Gahmberg CG,  Parker PJ and Ivaska J (2009) PKCepsilon Regulation of an alpha5 Integrin–ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells. Science Signaling 2 (77): ra32

Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P and Grosse R (2009) SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol 11(5):557-68

Côme C, Laine A, Chanrion M, Edgren H, Mattila E, Liu X, Jonkers J, Ivaska J, Isola J, Darbon J, Kallioniemi O, Thézenas S and Westermarck J (2009) CIP2A is associated with human breast cancer aggressivity. Clin Cancer Res 15: 5092-5100 

Nevo J, Mattila E, Pellinen T, Yamamoto DL, Sara H, Iljin K, Kallioniemi O, Bono P, Joensuu H, Wärri A and Ivaska J (2009) Mammary Derived growth inhibitor facilitates escape from EGFR inhibitory therapy. Clin Cancer Res 15:6570-6578

Selivanova G, Ivaska J (2009) Integrins and mutant p53 on the road to metastasis. Cell 139:1220-1222 

2008

Lehto M, Mäyräpää MI, Pellinen T, Ihalmo P, Lehtonen S, Kovanen PT, Groop PH, Ivaska J and Olkkonen VM (2008) A novel R-Ras interaction partner, OSBP related protein 3 (ORP3), regulates cell adhesion. J Cell Sci 121:695-705

Mattila E, Koskinen K, Salmi M. and Ivaska J (2008) Protein tyrosine phosphatase TCPTP controls VEGFR-2 signalling. J Cell Sci 121:3570-80

Vuoriluoto K, Jokinen J, Salmivirta M, Heino J and Ivaska J (2008) Syndecan-1 supports integrin α2β1 mediated adhesion to collagen. Exp Cell Res 314:3369-81

Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A and Zent R. (2008) Crosstalk between integrins α1β1 and α2β1 in renal epithelial cells. Exp Cell Res 314:3593-604

Pellinen T, Tuomi S, Arjonen A, Wolf M, Edgren H, Meyer H, Grosse R, Kitzing T, Rantala JK, Kallioniemi O, Fässler R, Kallio M, and Ivaska J (2008) Integrin traffic regulated by Rab21 is necessary for cytokinesis. Dev Cell 15:371-385

2007

Junttila MR, Puustinen P, Niemelä M, Ahola R, Nielsen C, Kallunki T, Ivaska J, Arnold H, Lu SL, Wang XJ, Kähäri VM, Westermarck J (2007) CIP2A inhibits PP2A in Human Malignancies. Cell 130:51-62

Vihinen P, Kallioinen M, Vuoristo MS, Ivaska J, Syrjänen KJ, Hahka-Kemppinen M, Kellokumpu-Lehtinen PL, Pyrhönen SO (2007) Serum angiogenin levels predict treatment response in patients with stage IV melanoma. Clin Exp Metastasis 24:567-74

Ivaska J, Pallari HM, Nevo J, Eriksson JE (2007) Novel functions of vimentin in cell adhesion, migration, and signaling. Exp Cell Res 313:2050-62

2006

Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J (2006) Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol 173:767-80 

Pellinen T and Ivaska J (2006) Integrin traffic, invited commentary. J Cell Sci 119:3723-31

2005

Mattila E, Pellinen T, Nevo J, Vuoriluoto K, Arjonen A and Ivaska J (2005) Negative regulation of EGFR signalling via integrin α1β1-mediated activation of protein tyrosine phosphatase TCPTP. Nature Cell Biol 7:78-85

Ivaska J, Vuoriluoto, K, Huovinen, T, Izawa, I, Inagiki, K, and Parker, PJ. (2005) PKCepsilon mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J 24:3834-3845

2004

Upla P, Marjomäki V, Kankaanpää P, Ivaska J, Hyypiä T, van der Goot FG and Heino J (2004) Clustering induces a lateral redistribution of ?2?1 integrin from membrane rafts to caveolae and PKC-dependent internalization. Mol Biol Cell 15:625-636

Jokinen J, Dadu E, Nykvist P, Käpylä J, White DJ, Ivaska J, Vehvilainen P, Reunanen H, Larjava H, Hakkinen L, Heino J (2004) Integrin mediated cell adhesion to type I collagen fibrils. J Biol Chem 279:31956-31963

Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris R.C, Pozzi A and Zent R. (2004) Differential expression of collagen and laminin binding integrins mediate ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol-Renal 287:F602-11

Book Chapters:

Alanko J, Hamidi H and Ivaska J. Signaling from Endosomes (2015). In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 2: Organisational Cell Biology, Waltham, MA: Academic Press, pp. 211-224

Iljin K, Kilpinen S, Ivaska J and Kallioniemi O (2008) Meta-analysis of gene expression microarray data: degradome genes in healthy and cancer tissues. D.Edwards et al., (eds.) The Cancer Degradome. Springer Science+Business Media p.633-649