Cytoskeletal and survival signaling

Group Leader

John Eriksson
Professor
Department of Biosciences
Åbo Akademi University
john.eriksson[at]abo.fi  john.eriksson[at]btk.fi

Contact Information

Turku Centre for Biotechnology
P.O. Box 123, BioCity
(Street addr. Tykistökatu 6 B)
FIN-20521 Turku, Finland
+358-2-215-3313 (John Eriksson)
+358-2-333-8603 (Departmental Office)
+358-2-215-4061 (Main PhD Student Office)
+358-2-333-8000 (Fax Attn. John Eriksson)

Conferences

Gordon Research Conference 2014: Intermediate Filaments at the Crossroads Between Health and Disease

The 24th Sigrid Juselius Symposium

Research Area and Interests

Post-translational modifications (PTMs) modulate the activity of most eukaryotic proteins and are responsible for producing highly complex proteomes from relatively simple genomes. We use a selection of signaling networks that represent the core of our expertise to identify PTM targets and interactions when a cell is embarking upon fate-determining responses, such as activating defense and survival mechanisms or triggering death machineries.  Our main models are apoptotic, stress-mediated, and cytoskeletal signaling and we are also interested in their interrelationship. By exploring the interactions between these completely different signaling modalities, we hope to advance our understanding how critical intracellular signals are processed and integrated.

Selected publications

Projects

Intermediate filaments as signaling determinants

Signal transduction in receptor-mediated apoptosis and cell survival

Technology transfer

Group Members

John Eriksson
Hend Abdelkader
Fang “Rose” Cheng
Josef Gullmets
Alia Joko
Henok Karvonen
Julia Lindqvist
Ponnuswamy Mohanasundaram
Erik Niemelä
Preethy Paul
Leila Rato
Rajendran Senthil Kumar
Michael Silva
Maria Sippola-Thiele
Elin Torvaldson
Arun Venu
Num Wistbacka

Funding

The Academy of Finland, Tekes, European Union, Sigrid Juselius Foundation, Åbo Akademi University Foundation, Finnish Cancer Foundations