The 24th Sigrid Juselius Symposium

POST-TRANSLATIONAL MODIFICATION NETWORKS AS SURVIVAL DETERMINANTS

 
Hanasaari – The Swedish-Finnish Cultural Centre

Espoo, Finland,  June 10-13, 2011

Post-translational modifications (PTMs) modulate the activity of most eukaryotic proteins and are responsible for producing highly complex proteomes from relatively simple genomes. While the proteome-wide analysis of these modifications represents daunting challenges, this type of analysis will be critical to resolve the true functions of signal processing units in the cell. A major task of the cellular signaling machinery is to handle the multitude of stimuli that are related to various forms of developmental, stress, disease, or aging cues.

In the outlined symposium program, our goal is to exemplify by a selection of signaling systems how different PTM networks work together to control key processes in the cell. We also want to demonstrate that by deciphering these PTM networks important information can be obtained to understand the key signaling events underlying a broad spectrum of disease conditions ranging from immunological disorders and infectious diseases to cancer as well as aging and age-related diseases. Furthermore, the symposium will highlight how identification of critical nodes of these PTM networks can be employed for development of new therapies and drugs.

In summary, we believe that this interdisciplinary and integrating view of signaling is very timely. The speakers represent the absolute elite in their respective fields of research, many of them being founders or discoverers of the signaling systems or phenomena that they are about to describe. By bringing these experts together we also hope that we may reach a synergistic “enlightening” effect by the symposium that would be hard to achieve by any other means.

Organizers:

John Eriksson and Lea Sistonen, Åbo Akademi University

Other members of the organizing committee:

Jorma Palvimo, University of Eastern Finland

Jukka Westermarck, University of Turku

NB! Participation in this symposium is by invitation only.

PROGRAM

Friday, June 10

13:00-16:00    Arrival, Registration, Poster Set-up

16:00    Opening of the Symposium
              Caj Haglund, Secretary of the Medical Board of the Sigrid Juselius Foundation

Session 1: p53 as a Signal Integrator and Pharmaceutical Target

Chair: Jukka Westermarck

16:20    David Lane, Institute of Molecular and Cell Biology, A*Star, Singapore:
Controlling p53 Protein Levels in Cancer and Normal Cells
16:55    Jean-Christophe Marine, University of Leuven, Leuven, Belgium:
Selective Killing of Cancer Cells by Targeting Synthetic Lethal Partners of Tumor Suppressor p53
17:30    Lyubomir Vassilev, Roche Cancer Center, Nutley, NJ, USA:
Pharmacological Intervention in p53 Regulation by MDM2 Antagonists

18:30    Piano Recital: Antti Hotti

19:00    Welcome Dinner

20:30    Get-together at the Posters

 

Saturday, June 11

Session 2: Survival Nodes among Kinase Networks

Chair: Jorma Palvimo

08:30    Tony Hunter, Salk Institute for Biological Studies, La Jolla, CA, USA:
Why Nature Chose to Use Protein Phosphorylation as a Regulatory Mechanism
09:05    Dirk Bohmann, University of Rochester Medical Center, NY, USA:
Extracellular Signaling Networks Regulating FGF Activity
09:40    Rosalie Sears, Oregon Health & Science University, Portland, OR, USA:
Post-translational Regulations of c-Myc Stability and Oncogenic Activity

10:15    Coffee/Tea

10:40    Jukka Westermarck, Turku Centre for Biotechnology, University of Turku, Finland:
Novel Role for Protein Phosphatase 2A (PP2A) Inhibitor CIP2A in DNA Damage Response
11:15    Kari Vaahtomeri, Institute for Biotechnology, University of Helsinki, Finland:
LKB1 Tumor Suppressor in Control of Actin Stress Fibers
11:30    Markko Pesu, University of Tampere, Finland:
Proprotein Convertase Furin in T Cell Biology
11:45    Grzegorz Sarek, Biomedicum Helsinki, University of Helsinki, Finland:
Viral Lytic Replication Compromises Apoptotic Response to p53 Reactivation in KSHV
Lymphomas

12:00    Lunch

Session 3: Ubiquitin in Cell Death and Survival

Chair: Cecilia Sahlgren

13:30    Ivan Dikic, Goethe University School of Medicine, Frankfurt, Germany:
Ubiquitin and Autophagy Networks
14:05    Pascal Meier, The Breakthrough Toby Robins Cancer Research Centre, London, UK:
IAPs: from Caspase Inhibitors to Modulators of NF-κB, Inflammation and Cancer
14:40    Ramin Massoumi, Lund University, Malmö, Sweden:
The Role of Deubiquitination in Cell Signaling and Cancer

15:15    Coffee/Tea

15:45    Urban Lendahl, Karolinska Institute, Stockholm, Sweden:
Notch and Hypoxia Cross-talk in Development and Cancer
16:20    John Silke, La Trobe University, Victoria, Australia:
The Regulation of TNF Signaling
16:55    Jeffrey L. Brodsky, University of Pittsburgh, PA, USA:
Critical Mediators of Ubiquitinated Protein Turnover during ER Associated Degradation (ERAD)

18:00    Poster Session

19:30    Dinner

21:00    A Journey through the Roots of Jazz: Anders Östling Trio
(Anders Östling, guitar; Jouni Hokkanen, bass; Anthony Johnson, violin & guitar)

 

Sunday, June 12

Session 4: SUMO and Ubiquitin-like Switches

Chair: Ville Hietakangas

08:30    Anne Dejean, Pasteur Institute, Paris, France:
Role of SUMOylation in Intestinal Homeostasis and Cancer
09:05    Ron T. Hay, University of Dundee, UK:
How SUMO Talks to Ubiquitin
09:40    Jorma J. Palvimo, University of Eastern Finland, Kuopio, Finland:
Modulation of Steroid Signaling by SUMOylation

10:15    Coffee/Tea

10:45    Stefan Jentsch, Max Planck Institute, Martinsried, Germany:
Role of Ubiquitin-like Protein in RNA Splicing
11:20    Andrea Pichler, Max Planck Institute of Immunobiology, Freiburg, Germany:
Ubc9 Sumoylation in Saccharomyces cerevisiae

12:00    Lunch

Session 5: Decisions between Survival and Death

Chair: Juha Klefström

13:30    Marja Jäättelä, Danish Cancer Society, Copenhagen, Denmark:
Lyosomes in the Control of Cancer Cell Invasiveness and Survival
14:05    Henning Walczak, Imperial College London, London, UK:
Linear Ubiquitination in the TNF Superfamily Signaling
14:40    Mart Saarma, Institute of Biotechnology, University of Helsinki, Finland:
Novel Neurotrophic Factors Rescue Neuronal Death

15:15    Coffee/Tea

Session 6: Cytoskeleton-Signaling Interactions

Chair: Diana Toivola

15:45    M. Bishr Omary, University of Michigan Medical School, Ann Arbor, MI, USA:
Post-translational Regulation of Keratins in Simple Epithelia
16:20    E. Birgit Lane, Institute of Medical Biology, A*Star, Singapore:
Keratin Modulation in Response to Stress: Clues from Genetic Skin Disorders
16:55    Robert D. Goldman, Northwestern University School of Medicine, Chicago, IL, USA:
Signal Transduction along Intermediate Filament Networks: Regulation of Cell Shape and
Motility
17:30    John E. Eriksson, Åbo Akademi University, Turku, Finland:
Intermediate Filaments as Signaling Modules

19:00    Helsinki Cruise & Dinner

 

Monday, June 13

Session 7: Stress Responses and Protein Homeostasis

Chair: Carina Holmberg-Still

08:30    Richard I. Morimoto, Northwestern University, Evanston, IL, USA:
Healthy Proteostasis: Protecting the Proteome against Aging and Disease
09:05    M. Gabriella Santoro, University of Rome Tor Vergata, Rome, Italy:
HSF1 at the Crossroad of Inflammatory and Survival Signaling
09:40    Lea Sistonen, Åbo Akademi University, Turku, Finland:
Post-translational Modifications Regulating the Activity and Expression of HSFs

10:15    Coffee/Tea

10:40    Carmen Garrido, University of Bourgogne, Dijon, France:
Hsp27 Induces HIF2alpha Proteasomal Degradaton in a VHL-Independent Manner
11:15    Anne Brunet, Stanford University School of Medicine, Stanford, CA, USA:
FoxO Transcription Factors in Aging and Stem Cells
11:50    Andrew Dillin, The Salk Institute for Biological Studies, La Jolla, CA, USA:
Proteostasis in Aging and Stem Cells

12:30    Closing Remarks
              Lea Sistonen

13:00    Lunch

14:00    Departure