Molecular Systems Immunology

Group Leader

Riitta Lahesmaa, Academy Professor, Academy of Finland
Director, Turku Centre for Biotechnology (leave of absence until Dec 31, 2020)
riitta.lahesmaa [at] utu.fi

Contact Information

Molecular Immunology Group
Turku Centre for Biotechnology
P.O. Box 123, BioCity
(Street adr. Tykistökatu 6 B)
FIN-20521 Turku, Finland
+358-2-333 8601 (Riitta Lahesmaa)
+358-40-718 4813 (Mobile)
+358-2-333 8011 (Laboratory)
+358-2-2518808  (fax)

Group Members

Laboratory Manager

Anne Lahdenperä, Ph.D.
anne.lahdenpera [at] btk.fi

Visiting Professors/Scientists:

John Andersson, Karolinska Institutet, Sweden
Cisca Wijmenga, University of Groningen, Netherlands

Senior Scientists/Postdoctoral Fellows

Rafael Sales De Albuquerque, Ph.D.
Tanja Buchacher, Ph.D.
Henna Kallionpää, Ph.D.
Lingjia Kong, Ph.D.
Niina Lietzen, Ph.D.
Robert Moulder, Ph.D.
Senthil Palani, Ph.D.
Omid Rasool, Ph.D., Adjunct Professor
Subhash Tripathi, Ph.D.
Ubaid Ullah, Ph.D.

Ph.D. Students

Bilal Andrabi, M.Sc.
Santosh Bhosale, M.Sc.
Karoliina Hirvonen, M.Sc.
Kartiek Kanduri, M.Sc.
Mohd Moin Khan, M.Sc.
Essi Laajala, M.Sc. (tech)
Verna Salo, M.Sc.
Ankitha Shetty, M.Sc.

Undergraduate Students

Victoria Hinkkanen
Sameer Jagirdar
Elina Komsi

Technicians

Marjo Hakkarainen
Sarita Heinonen
Päivi Junni

Projects

Type 1 Diabetes

Th Cell Differentiation

Funding

The Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (http://www.symmys.fi/index.html), The Academy of Finland, The Sigrid Jusélius Foundation,  The Juvenile Diabetes Research Foundation (JDRF), EUFP7, National Technology Agency of Finland (TEKES), The Finnish Cancer Organizations, University of Turku Graduate School (UTUGS), Turku University Hospital Fund, University of Turku, Åbo Akademi University.

Key Collaborations

Burge Christopher, MIT, Cambridge, USA
Galande Sanjeev, National Centre for Cell Science, NCCS, Pune, India
Goodlett David, University of Baltimore and Turku Centre for Biotechnology
Knip Mikael, University of Helsinki
Lähdesmäki Harri, Turku Centre for Biotechnology and Aalto University
Rao Anjana, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Ren Bing, Ludwig Institute for Cancer Research, University of California, San Diego, USA
Toppari Jorma, University of Turku
Weissman Irving, Stanford University
Wijmenga Cisca, University of Groningen, Groningen, Netherlands

Selected Publications

Tuomela S, Rautio S, Ahlfors H, Öling V, Salo V, Ullah U, Chen Z, Hämälistö S, Tripathi SK, Äijö T, Rasool O, Soueidan H, Wessels L, Stockinger B, Lähdesmäki H, Lahesmaa R. (2016) Comparative analysis of human and mouse transcriptomes of Th17 cell priming. Oncotarget. 7(12):13416-28.

Kanduri K, Tripathi S, Larjo A, Mannerström H, Ullah U, Lund R, Hawkins RD, Ren B, Lähdesmäki H, Lahesmaa R. (2015) Identification of global regulators of T-helper cell lineage specification. Genome Med. 7:122. 

Heinonen MT, Laine AP, Söderhäll C, Gruzieva O, Rautio S, Melén E, Pershagen G, Lähdesmäki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R; Finnish Pediatric Diabetes Registry. (2015) GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy. J Immunol. 194(12):5885-94.

Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. (2015) Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility. Diabetes. 64(6):2265-78.

Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. (2015) The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports. 4:519-528.

Tripathi SK, Lahesmaa R. (2014) Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev. 261(1):62-83.

Tuomela S, Lahesmaa R. (2013) Early T helper cell programming of gene expression in human. Semin Immunol. 25(4):282-90.

Hawkins RD, Larjo A, Tripathi SK, Wagner U, Luu Y, Lönnberg T, Raghav SK, Lee LK, Lund R, Ren B, Lähdesmäki H, Lahesmaa R. (2013) Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity. 38(6):1271-84.

Tahvanainen J, Kyläniemi MK, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, Rajavuori A, Rasool O, Koskinen PJ, Rao KV, Lähdesmäki H, Lahesmaa R. (2013) Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation. J Biol Chem. 288(5):3048-58.

Aijö T, Edelman SM, Lönnberg T, Larjo A, Kallionpää H, Tuomela S, Engström E, Lahesmaa R, Lähdesmäki H. (2012) An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation. BMC Genomics. 13:572.

Lund RJ, Närvä E, Lahesmaa R. (2012) Genetic and epigenetic stability of human pluripotent stem cells. Nat Rev Genet. 13(10):732-44

Tuomela S, Salo V, Tripathi SK, Chen Z, Laurila K, Gupta B, Äijö T, Oikari L, Stockinger B, Lähdesmäki H, Lahesmaa R. (2012) Identification of early gene expression changes during human Th17 cell differentiation. Blood. 119(23):e151-60.

Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R. (2011) RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. Stem Cells 30(3):452-60

O’Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y. (2011) Genomic views of STAT function in CD4(+) T helper cell differentiation. Nature Reviews Immunology. 11:239-250

Hussein S, Batada N, Vuoristo S, Ching R, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, Bazett-Jones D, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T. (2011) Copy number variation and selection during reprogramming to pluripotency. Nature, 471:58-62

Koh KP, Yabuuchi A, Rao S, Cunniff K, Laiho A, Tahiliani M, Huang Y, Thompson E, Nardone J, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SO, Rodig SJ, Daley GQ, Rao A. (2011) Tet1 and related 5-methylcytocine hydroxylases modulate pluripotency and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell, 8:200-213

Elo LL, Järvenpää H, Tuomela S, Raghav S, Ahlfors H, Laurila K, Gupta B, Lund RJ, Tahvanainen J, Hawkins RD, Oresic M, Lähdesmäki H, Rasool O, Rao KV, Aittokallio T, Lahesmaa R. (2010) Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity. 32:852-62.

Ahlfors H, Limaye A, Elo-Uhlgrén L, Notani D, Gottimukkala K, Burute M, Tuomela S, Rasool O, Galande S* & Lahesmaa R*.  (2010) SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation. *Equal contribution. Blood. 116:1443-53.

Moulder R*, Lönnberg T*, Filén J-J, Elo L, Rainio E, Corthals G, Oresic M, Nyman TA, Aittokallio T, Lahesmaa R (*equal contribution). (2010) Quantitative Proteomics Analysis of the Nuclear Fraction of Human CD4+ Cells in the Early Phases of IL-4 Induced Th2 Differentiation. Molecular Cellular Proteomics. 9:1937-53.

Närvä E, Autio R, Rahkonen N, Kong L, Harrison N, Kitsberg D, Borghese L, Itskovitz-Eldor J, Rasool O, Dvorak P, Hovatta O, Otonkoski T, Tuuri T, Cui W, Brüstle O, Baker D, Maltby E, Moore HD, Benvenisty N, Andrews PW, Yli-Harja O, Lahesmaa R. (2010) High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nature Biotechnology. 2010 28:371-379.

Filén S, Ylikoski E, Tripathi S, West A, Björkman M, Nyström J, Ahlfors H, Coffey E, Rao KV, Rasool O, Lahesmaa R. (2010) Activating transcription factor 3 is a positive regulator of human IFNG gene expression. J Immunol. 184(9):4990-9.

Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R. (2010) Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling. J Autoimmun. 35(1):70-6.

Cho SH, Goenka S, Henttinen T, Gudapati P, Reinikainen A, Lahesmaa R, Boothby M.  (2009) PARP-14, a member of the B aggressive lymphoma (BAL) family, transduces survival signals in primary B cells. Blood. 113(11):2416-25.

Tahvanainen J, Kallonen T, Lähteenmäki H, Heiskanen K, Westermarck J, Rao KV and Lahesmaa R. (2009) PRELI is a mitochondrial regulator of human primary T helper cell apoptosis, STAT6 and Th2 cell differentiation. Blood. 113(6):1268-77.

Filén JJ, Filén S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Björkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R. (2009) Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation. Mol Cell Proteomics. 8(1):32-4.

Link to all publications