Molecular Systems Immunology

Group Leader

Riitta Lahesmaa, Academy Professor, Academy of Finland
Director, Turku Centre for Biotechnology (leave of absence until Dec 31, 2020)
riitta.lahesmaa [at] utu.fi

Contact Information

Molecular Immunology Group
Turku Centre for Biotechnology
P.O. Box 123, BioCity
(Street adr. Tykistökatu 6 B)
FIN-20521 Turku, Finland
+358-2-333 8601 (Riitta Lahesmaa)
+358-40-718 4813 (Mobile)
+358-2-333 8011 (Laboratory)
+358-2-2518808  (fax)

https://www.aka.fi/en/about-us/media/whats-new/2018/making-it-to-the-top-by-studying-the-regulation-of-the-immune-system/

https://www.utu.fi/en/news/press-release/researchers-discovered-new-immune-response-regulators

 

Group Members

Laboratory Manager

Anne Lahdenperä, Ph.D.
anne.lahdenpera [at] btk.fi

Visiting Professors/Scientists:

John Andersson, Karolinska Institutet, Sweden
Cisca Wijmenga, University of Groningen, Netherlands

Senior Scientists/Postdoctoral Fellows

Andrabi Syed Bilal Ahmad, Ph.D.
Santosh Bhosale, Ph.D.
Tanja Buchacher, Ph.D.
Meraj Khan, Ph.D.
Niina Lietzen, Ph.D.
Robert Moulder, Ph.D.
Omid Rasool, Ph.D., Adjunct Professor
Subhash Tripathi, Ph.D.
Ubaid Ullah, Ph.D.
Meraj Khan Ph.D.

Ph.D. Students

Karoliina Hirvonen, M.Sc. (on leave)
Kartiek Kanduri, M.Sc.
Mohd Moin Khan, M.Sc.
Essi Laajala, M.Sc. (tech)
Verna Salo, M.Sc.
Ankitha Shetty, M.Sc.

Undergraduate Students

Sonja Granroth
Sara Soikkeli

Technicians

Marjo Hakkarainen
Sarita Heinonen

Projects

Type 1 Diabetes

Th Cell Differentiation

Funding

The Academy of Finland, The Sigrid Jusélius Foundation,  The Juvenile Diabetes Research Foundation (JDRF), EU Horizon 2020, Business Finland, The Finnish Cancer Organizations, The Diabetes Foundation (Diabetessäätiö), University of Turku Graduate School (UTUGS), University of Turku.

Key Collaborations

Elo Laura, Turku Centre for Biotechnology
Galande Sanjeev, National Centre for Cell Science, NCCS, Pune, India
Knip Mikael, University of Helsinki
Lähdesmäki Harri, Turku Centre for Biotechnology and Aalto University
Toppari Jorma, University of Turku
Weissman Irving, Stanford University
Wijmenga Cisca, University of Groningen, Groningen, Netherlands

Selected Publications

Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA. Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. Cell. Jan 7, 2019.

Subhash K. Tripathi SK, Välikangas T, Shetty A, Khan MM, Moulder R, Bhosale SD, Komsi E, Salo V, Sales De Albuquerque R, Rasool O, Galande S, Elo LL, Lahesmaa R. Quantitative mass spectrometry-based proteomics reveals the dynamic protein landscape during initiation of human Th17 cell polarization (2018) iScience, in press.

Mathieu C, Lahesmaa R, Bonifacio E, Achenbach P, Tree T. (2018) Immunological biomarkers for the development and progression of type 1 diabetes. Diabetologia. 61(11):2252-2258. Review.

Schmidt A, Marabita F, Kiani NA, Gross CC, Johansson HJ, Éliás S, Rautio S, Eriksson M, Fernandes SJ, Silberberg G, Ullah U, Bhatia U, Lähdesmäki H, Lehtiö J, Gomez-Cabrero D, Wiendl H, Lahesmaa R, Tegnér J. (2018) Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3. BMC Biol. 16(1):47.

Ullah U, Andrabi SBA, Tripathi SK, Dirasantha O, Kanduri K, Rautio S, Gross CC, Lehtimäki S,  Bala K, Tuomisto J, Bhatia U, Chakroborty D, Elo L, Lähdesmäki H, Wiendl H, Rasool O, Lahesmaa R. (2018) Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells. Cell Rep. 22(8):2094-2106.

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL. (2018) Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes. Diabetologia. 61(2):381-388.

Tripathi SK, Chen Z, Larjo A, Kanduri K, Nousiainen K, Äijo T,  Ricaño-Ponce I, Hrdlickova B, Tuomela S,  Laajala E, Salo V, Vinod Kumar V, Wijmenga C, Lähdesmäki H, Lahesmaa R. (2017) Genome-wide analysis of STAT3 mediated transcription during early human Th17 cell differentiation. Cell Reports 19(9):1888-1901.

Lund RJ, Rahkonen N, Malonzo M, Kauko L, Emani MR, Kivinen V, Närvä E, Kemppainen E, Laiho A, Skottman H, Hovatta O, Rasool O, Nykter M, Lähdesmäki H, Lahesmaa R. (2017) RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Stem Cell Reports. 8(5):1442-1454.

Tuomela S, Rautio S, Ahlfors H, Öling V, Salo V, Ullah U, Chen Z, Hämälistö S, Tripathi SK, Äijö T, Rasool O, Soueidan H, Wessels L, Stockinger B, Lähdesmäki H, Lahesmaa R. (2016) Comparative analysis of human and mouse transcriptomes of Th17 cell priming. Oncotarget. 7(12):13416-28.

Kanduri K, Tripathi S, Larjo A, Mannerström H, Ullah U, Lund R, Hawkins RD, Ren B, Lähdesmäki H, Lahesmaa R. (2015) Identification of global regulators of T-helper cell lineage specification. Genome Med. 7:122. 

Heinonen MT, Laine AP, Söderhäll C, Gruzieva O, Rautio S, Melén E, Pershagen G, Lähdesmäki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R; Finnish Pediatric Diabetes Registry. (2015) GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy. J Immunol. 194(12):5885-94.

Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. (2015) Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility. Diabetes. 64(6):2265-78.

Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. (2015) The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports. 4(3):519-528.

Tripathi SK, Lahesmaa R. (2014) Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev. 261(1):62-83.

Tuomela S, Lahesmaa R. (2013) Early T helper cell programming of gene expression in human. Semin Immunol. 25(4):282-90.

Hawkins RD, Larjo A, Tripathi SK, Wagner U, Luu Y, Lönnberg T, Raghav SK, Lee LK, Lund R, Ren B, Lähdesmäki H, Lahesmaa R. (2013) Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity. 38(6):1271-84.

Tahvanainen J, Kyläniemi MK, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, Rajavuori A, Rasool O, Koskinen PJ, Rao KV, Lähdesmäki H, Lahesmaa R. (2013) Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation. J Biol Chem. 288(5):3048-58.

Lund RJ, Närvä E, Lahesmaa R. (2012) Genetic and epigenetic stability of human pluripotent stem cells. Nat Rev Genet. 13(10):732-44

Tuomela S, Salo V, Tripathi SK, Chen Z, Laurila K, Gupta B, Äijö T, Oikari L, Stockinger B, Lähdesmäki H, Lahesmaa R. (2012) Identification of early gene expression changes during human Th17 cell differentiation. Blood. 119(23):e151-60.

Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R. (2011) RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. Stem Cells. 30(3):452-60

O’Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y. (2011) Genomic views of STAT function in CD4(+) T helper cell differentiation. Nature Reviews Immunology. 11:239-250

Hussein S, Batada N, Vuoristo S, Ching R, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, Bazett-Jones D, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T. (2011) Copy number variation and selection during reprogramming to pluripotency. Nature. 471:58-62

Koh KP, Yabuuchi A, Rao S, Cunniff K, Laiho A, Tahiliani M, Huang Y, Thompson E, Nardone J, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SO, Rodig SJ, Daley GQ, Rao A. (2011) Tet1 and related 5-methylcytocine hydroxylases modulate pluripotency and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 8:200-213

Elo LL, Järvenpää H, Tuomela S, Raghav S, Ahlfors H, Laurila K, Gupta B, Lund RJ, Tahvanainen J, Hawkins RD, Oresic M, Lähdesmäki H, Rasool O, Rao KV, Aittokallio T, Lahesmaa R. (2010) Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity. 32:852-62.

Närvä E, Autio R, Rahkonen N, Kong L, Harrison N, Kitsberg D, Borghese L, Itskovitz-Eldor J, Rasool O, Dvorak P, Hovatta O, Otonkoski T, Tuuri T, Cui W, Brüstle O, Baker D, Maltby E, Moore HD, Benvenisty N, Andrews PW, Yli-Harja O, Lahesmaa R. (2010) High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nature Biotechnology. 28:371-379.

Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R. (2010) Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling. J Autoimmun. 35(1):70-6.

Link to all publications