Publications

Molony Leukemia Virus (MLV retrovirus)

Mohammad, H#, Marchisella, F#, Ortega-Martinez, S#, Hollos, P, Eerola, K, Komulainen, E, Kulesskay, N, Savontous, E, Rauvala, H, Peterson, B, Van Praag, H, Coffey, ET. JNK1 controls adult hippocampal neurogenesis and imposes cell autonomous control of anxiety behaviour from the hippocampal neurogenic niche. Molecular Psychiatry, NPG, 2016 in press. # equal contribution.

This study uses retroviruses to specifically target immature granule cells of the hippocampus and finds that kinase disruption in under 200 neurogenic niche cells lowers anxiety and depressive behaviour.

Lenti Vectors

Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET. JNK Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells. Molecular and Cellular Biology. 2012 Mol Cell Biol. 32(17):3513-26

This study using Lenti vectors to generate stable knockdown cell lines. These approaches help establish the importance of MARCKSL1 and JNK in cancer cell migration.

Boström P, Sainio A, Kakko T, Savontaus M, Söderström M, Järveläinen H. Localization of decorin gene expression in normal human breast tissue and in benign and malignant tumors of the human breast. Histochem Cell Biol. 2013 Jan;139(1):161-71.

Laine A, Sihto H, Come C, Rosenfeldt MT, Zwolinska A, Niemelä M, Khanna A, Chan EK, Kähäri VM, Kellokumpu-Lehtinen PL, Sansom OJ, Evan GI, Junttila MR, Ryan KM, Marine JC, Joensuu H, Westermarck J. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov. 2013 Jan 10.

Adeno Vectors

Toivonen R, Koskenvuo J, Merentie M, Söderström M, Ylä-Herttuala S, Savontaus M.Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5. Virol J. 2012 29;9:296.

Histochem Cell Biol. 2010 133(3):349-57. Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart. Toivonen R, Mäyränpää MI, Kovanen PT, Savontaus M.

Dias JD, Guse K, Nokisalmi P, Eriksson M, Chen DT, Diaconu I, Tenhunen M, Liikanen I, Grénman R, Savontaus M, Pesonen S, Cerullo V, Hemminki A. Multimodal approach using oncolytic adenovirus, cetuximab, chemotherapy and  radiotherapy in HNSCC low passage tumour cell cultures. Eur J Cancer. 2010 46(3):625-35.

Suominen E, Toivonen R, Grenman R, Savontaus M. Head and neck cancer cells are efficiently infected by Ad5/35 hybrid virus. J Gene Med. 2006 8(10):1223-31.

Moilanen AM, Rysä J, Mustonen E, Serpi R, Aro J, Tokola H, Leskinen H, Manninen A, Levijoki J, Vuolteenaho O, Ruskoaho H. Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms. Circ Heart Fail. 2011 4(4):483-95.

Serpi R, Tolonen AM, Huusko J, Rysä J, Tenhunen O, Ylä-Herttuala S, Ruskoaho H. Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats. Cardiovasc Res. 2011 Jan 1;89(1):204-13.

Ala-Kopsala M, Moilanen AM, Rysä J, Ruskoaho H, Vuolteenaho O. Characterization of molecular forms of N-terminal B-type natriuretic peptide in vitro. Clin Chem. 2010 56(12):1822-9

Rysä J, Tenhunen O, Serpi R, Soini Y, Nemer M, Leskinen H and Ruskoaho H. (2010) GATA-4 is an angiogenic survival factor of the infracted heart. Circ. Heart Fail. 3(3):440-50.

Endo H, Niioka M, Sugioka Y, Itoh J, Kameyama K, Okazaki I, Ala-Aho R, Kähäri VM, Watanabe T. Matrix metalloproteinase-13 promotes recovery from experimental liver cirrhosis in rats. Pathobiology. 2011;78(5):239-52.