Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Hot Off the Press
Marchisella, F., Coffey, ET, Hollos, P. Microtubules and microtubule associated proteins in psychiatric disease. Cytoskeleton 2016 Apr 26. Pubmed
Mahesh Tambe*, Sofia Pruikkonen*, Jenni Mäki-Jouppila, Ping Chen, Bente Vilming Elgaaen, Anne Hege Straume, Kaisa Huhtinen, Olli Cárpen, Per Eystein Lønning, Ben Davidson, Sampsa Hautaniemi and Marko J. Kallio. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel. Oncotarget Mar 2, 2016. *equal contribution. PubMed
Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Söderström M, Emani MR, Stubb A, Närvä E, Ghimire B, Laiho A, Järveläinen H, Lahesmaa R, Lähdesmäki H, Hawkins RD, Lund RJ. Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells. Sci Rep. 2016 Feb 25;6:22190. Pubmed
Kohtala S, Theilmann W, Suomi T, Wigren HK, Porkka-Heiskanen T, Elo LL, Rokka A, Rantamäki T. Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus. ACS Chem Neurosci. 2016 Apr 28. [Epub ahead of print] Pubmed
Conesa A, Madrigal P, Tarazona S, Gomez-Cabrero D, Cervera A, McPherson A, Szcześniak MW, Gaffney DJ, Elo LL, Zhang X, Mortazavi A. A survey of best practices for RNA-seq data analysis. Genome Biol. 2016 Jan 26;17:13. Pubmed
Santio N, Landor S, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi S, Corthals G, Varjosalo M, Manoharan G, Uri A, Lendahl U, Sahlgren C* & Koskinen P*. Pim kinases regulate oncogenic Notch1 signaling. Oncotarget. Link
Braune EB, Tsoi YL, Phoon YP, Landor S, Silva Cascales H, Ramsköld D, Deng Q, Lindqvist A, Lian X, Sahlgren C, Jin SB, Lendahl U. Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells. Stem Cell Reports. 2016 Apr 4. E-pub ahead of print. Pubmed
Ba W, Selten MM, van der Raadt J, van Veen H, Li LL, Benevento M, Oudakker AR, Lasabuda RS, Letteboer SJ, Roepman R, van Wezel RJ, Courtney MJ, van Bokhoven H, Nadif Kasri N. ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function. Cell Rep. 2016 Feb 16;14(6):1355-68. Pubmed
Skopelitou K, Muleta AW, Papageorgiou AC, Chronopoulou EG, Pavli O, Flemetakis E, Skaracis GN, Labrou NE. Int J Biol Macromol. 2016 Pubmed
Christophe Côme, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimente, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H. Busch, Markus W. Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck. CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection. PLoS ONE 11(4) e0152996. Link
Padzik A*, Deshpande P*, Hollos P*, Franker M, Rannikko EH, Cai D, Prus P, Mågård M, Westerlund N, Verhey KJ, James P, Hoogenraad CC, Coffey ET. KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons. Front Cell Neurosci. 2016 Mar 15;10:57. *equal contribution. Pubmed
MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers. Sami Ventelä, Juho-Antti Mäkelä, Rosalie Sears C, Jorma Toppari, Jukka Westermarck. Matters, Mar 03, 2016. Link
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
Biomathematician Laura Elo Received Highly Competitive ERC Funding
Adjunct professor of Biomathematics Laura Elo from University of Turku has received a grant from the European Research Council (ERC). The grant is one of the most highly competitive grants in Europe. The ERC Starter Grant is 1.5 million euros.
Jouko Sandholm, University of Turku, 10th of June 2016, Toll-like receptor 9 in breast cancer
Heidi Högel, University of Turku, 20th of May 2016, Life without PHD? - PHD oxygen sensor proteins in hypoxic carcinoma cell survival
Riina Kaukonen, University of Turku, 22nd of April 2016, Filopodia and stromal extracellular matrix as regulators of cancer cell invasion and growth
Hasan Mohammad, Åbo Akademi University, 6th of April, 2016: JNK regulation of neurogenesis, neuroplasticity and anxiety-related behaviors in mice
Nicola De Franceschi, University of Turku, 12th of February 2016: Integrin cytoplasmic tail interactors: the insiders' game.
Arafath Kaja Najumudeen, Åbo Akademi University, 15th of January 2016: Targeting oncogenic signaling proteins - new insights using a FRET-based chemical biology approach
Asta Laiho, University of Turku, 9th of January 2016: Data analysis tools and methods for DNA microarray and high-throughput sequencing data
Sini Junttila, University of Turku, 8th of January 2016: Characterisation of Cladonia rangiferina transcriptome and genome, and the effects of dehydration and rehydration on its gene expression.
Pekka Heikkinen, University of Turku, 11th of December 2015: Modulation of TGF-β signaling by Hypoxia
Reetta Virtakoivu, University of Turku, 4th of December 2015: From epithelial to mesenchymal: regulation of invasive cancer cell motility From epithelial to mesenchymal: regulation of invasive cancer cell motility
Marika Sjöqvist, Åbo Akademi University, 13th of October 2015: Networking Notch : regulation of Notch traffic and signaling crosstalk
11th Seili Virus-Cell Interactions Symposium
Monday, August 15 at 10:15 - Wednesday, August 17 at 12:45
Seili Archipelago Research Institute, Nauvo
TuDMM Summer School 2016:
Microbes R Us
Wednesday, August 17 at 11:15
Dentalia Auditorium (Arje Scheinin), 2nd floor, LemminkÃ¤isenkatu 2
Frank Furnari :
The EGFR/PTEN signaling axis in glioblastoma: opportunities for therapeutic targeting and the uncoupling of heterogeneity
Thursday, August 18 at 12:00
Mauno Conference Center, President auditorium, BioCity, Turku