Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
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Guillaume Jacquemet, Habib Baghirov, Maria Georgiadou, Harri Sihto, Emilia Peuhu, Pierre Cettour-Janet, Tao He, Merja Perälä, Pauliina Kronqvist, Heikki Joensuu & Johanna Ivaska. L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nature Communications 7, Article number: 13297 (2016). Link
Suomi T, Elo LL. Accurate Detection of Differential Expression and Splicing Using Low-Level Features. Methods. Mol Biol. 2017. Pubmed
Laajala TD, Seikkula H, Seyednasrollah F, Mirtti T, Boström PJ, Elo LL. Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy. Sci Rep. Nov 2016. Pubmed
Mehrad Mahmoudian*, Fatemeh Seyednasrollah*, Liisa Koivu, Outi Hirvonen, Sirkku Jyrkkiö, Laura L. Elo. A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer. F1000Research. (*Equal contributors) Link
Perveen S, Rashid N, Papageorgiou AC. Crystal structure of a phosphoribosyl anthranilate isomerase from the hyperthermophilic archaeon Thermococcus kodakaraensis. Acta Cryst F 2016. Pubmed
Martinez-Bravo MJ, Wahlund CJ, Qazi KR, Moulder R, Lukic A, Rådmark O, Lahesmaa R, Grunewald J, Eklund A, Gabrielsson S. Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules.J Allergy Clin Immunol. 2016 Aug 23. [Epub ahead of print] Pubmed
Kaur A, Denisova O, Qiao X, Jumppanen M, Peuhu E, Ahmed SU, Raheem O, Haapasalo HK, Eriksson J, Chalmers AJ, Laakkonen PM, Westermarck J. PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Res. 2016 Sep 26. [Epub ahead of print] Pubmed
Tommi Välikangas, Tomi Suomi and Laura L. Elo. A systematic evaluation of normalization methods in quantitative label-free proteomics. Brief Bioinform (2016) Published online October 2, 2016. Pubmed
Lehtonen Š, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G. Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models. Antioxid Redox Signal. 2016 Sep 10;25(8):485-97. Pubmed
Axarli I, Muleta AW, Chronopoulou EG, Papageorgiou AC, Labrou NE. Directed Evolution of Glutathione Transferases Towards a Selective Glutathione-Binding Site and Improved Oxidative Stability. Biochim Biophys Acta. 2016 Sep 6. Pubmed
Waldemarson S, Kurbasic E, Krogh M, Cifani P, Berggård T, Borg Å, James P. Proteomic analysis of breast tumors shows the mRNA intrinsic molecular subtypes with different classifiers. Breast Cancer Res. 18(1):69. Pubmed
Jaakkola MK, Seyednasrollah F, Mehmood A and Elo LL. Comparison of methods to detect differentially expressed genes between single-cell populations. Briefings in bioinformatics. July 2016 [Epub ahead of print] PubMed
Baghirov H, Karaman D, Viitala T, Duchanoy A, Lou YR, Mamaeva V, Pryazhnikov E, Khiroug L, de Lange Davies C, Sahlgren C, Rosenholm JM. Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier. PLoS One. 2016 Aug 22;11(8):e0160705 Pubmed
Siljamäki E, Abankwa D. SPRED1 interferes with K-ras but not H-ras membrane anchorage and signaling. Mol Cell Biol. 2016 Aug 8. pii: MCB.00191-16. PubMed
Posada IM, Serulla M, Zhou Y, Oetken-Lindholm C, Abankwa D, Lectez B. ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold. PLoS One. 2016 Jul 20;11(7). eCollection 2016. Pubmed
Liu C, Skaldin M, Wu C, Lu Y, Zavialov AV. Application of ADA1 as a new marker enzyme in sandwich ELISA to study the effect of adenosine on activated monocytes. Sci Rep. 2016 Aug 11; 6:31370. Pubmed
Fang Cheng, Yue Shen, Ponnuswamy Mohanasundaram, Michelle Lindström, Johanna Ivaska, Tor Ny, and John E. Eriksson. Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling. PNAS 113(30), E4320–E4327. Pubmed
Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. 2016 Aug 4;7:12237. Pubmed
Mahesh Tambe, Elli Narvi, Marko Kallio. Reduced levels of Dusp3/Vhr phosphatase impair normal spindle bipolarity in an Erk1/2 activity-dependent manner. FEBS Lett. 2016 Jul 16. Pubmed
Lundahl MJ, Cunha AG, Rojo E, Papageorgiou AC, Rautkari L, Arboleda JC, Rojas OJ. Strength and Water Interactions of Cellulose I Filaments Wet-Spun from Cellulose Nanofibril Hydrogels. Sci Rep. 2016 Jul 28;6:30695. Pubmed
Rachel Barrow-McGee, Naoki Kishi, Carine Joffre, Ludovic Ménard, Alexia Hervieu, Bakhouche A. Bakhouche, Alejandro J. Noval, Anja Mai, Camilo Guzmán, Luisa Robert-Masson, Xavier Iturrioz, James Hulit, Caroline H. Brennan, Ian R. Hart, Peter J. Parker, Johanna Ivaska & Stéphanie Kermorgant. Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nature Communications 7, Article number: 11942. Pubmed
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
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Anni Vehmas, University of Turku, 2.9.2016, Tissue Proteomes: Quantitative Mass Spectrometry of Murine Liver and Ovarian Endometrioma
Jonna Alanko, University of Turku, 26th of August 2016, Integrin traffic and signalling – from plasma membrane to endosomes
Abdi Muleta, University of Turku, 26th of August 2016, Glutathione Transferases as Detoxification Agents: Structural and Functional Studies
Amanpreet Kaur, University of Turku, 19th of August 2016, The role of PME-1 in cancer: therapeutic implications
Jouko Sandholm, University of Turku, 10th of June 2016, Toll-like receptor 9 in breast cancer
Heidi Högel, University of Turku, 20th of May 2016, Life without PHD? - PHD oxygen sensor proteins in hypoxic carcinoma cell survival
Riina Kaukonen, University of Turku, 22nd of April 2016, Filopodia and stromal extracellular matrix as regulators of cancer cell invasion and growth
Hasan Mohammad, Åbo Akademi University, 6th of April, 2016: JNK regulation of neurogenesis, neuroplasticity and anxiety-related behaviors in mice
Nicola De Franceschi, University of Turku, 12th of February 2016: Integrin cytoplasmic tail interactors: the insiders' game.
Arafath Kaja Najumudeen, Åbo Akademi University, 15th of January 2016: Targeting oncogenic signaling proteins - new insights using a FRET-based chemical biology approach
Asta Laiho, University of Turku, 9th of January 2016: Data analysis tools and methods for DNA microarray and high-throughput sequencing data
Sini Junttila, University of Turku, 8th of January 2016: Characterisation of Cladonia rangiferina transcriptome and genome, and the effects of dehydration and rehydration on its gene expression.
Post-doctoral position in membrane traffic in cancer, application DL February 14, 2017.
Thursday, January 19 2017 at 12:00, Frontiers of Science seminar Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6 , Turku Professor Jussi Taipale, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden: Systems biology of cancer
Host: Jukka Westermarck
Wednesday, January 25 2017 at 11:15, MIKRO Seminars of Infection Biology and Infectious Diseases Arje Scheinin auditorium, Dentalia, Lemminkäisenkatu 2, 2nd floor Tero Ahola, University of Helsinki Discovering new antivirals agaisnt alphaviruses and other RNA viruses
Host: Petri Susi
Thursday, January 26 2017 at 12:00, Frontiers of Science seminar Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6 , Turku Dr. Marco Fritzsche, MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, UK: Cytoskeletal actin dynamics underpin immunological synapse formation
Host: Pieta Mattila