Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Hot Off the Press
Haikarainen, T., Loimaranta, V., Prieto-Lopez, C., Battula, P., Finne, J. & Papageorgiou, A.C. (2013). Expression, purification and crystallization of the C-terminal LRR domain of Streptococcus pyogenes 0843 protein. Acta Cryst F 69: 559-561. Pubmed
Battula, P., Dubnovitsky, A.P. & Papageorgiou, A.C. (2013). Structural basis of L-phosphoserine binding to Bacillus alcalophilus phosphoserine aminotransferase. Acta Crystallogr. D 69: 804-811. Pubmed
Prabhakar N, Näreoja T, von Haartman E, Karaman DS, Jiang H, Koho S, Dolenko TA, Hänninen PE, Vlasov DI, Ralchenko VG, Hosomi S, Vlasov II, Sahlgren C, Rosenholm JM. Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application. Nanoscale. 2013 Mar 15. [Epub ahead of print] Pubmed
Tahvanainen J, Kyläniemi MK, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, Rajavuori A, Rasool O, Koskinen PJ, Rao KV, Lähdesmäki H, Lahesmaa R. Proviral integration site for Moloney murine promote human T helper 1 cell differentiation. J Biol Chem. 2012 Dec 3. [Epub ahead of print] Pubmed
Laine A, Sihto H, Come C, Rosenfeldt MT, Zwolinska A, Niemelä M, Khanna A, Chan EK, Kähäri VM,Kellokumpu-Lehtinen PL, Sansom OJ, Evan GI, Junttila MR, Ryan KM, Marine JC, Joensuu H, Westermarck J. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov. 2013 Jan 10. [Epub ahead of print] Pubmed
Benson MJ, Aijö T, Chang X, Gagnon J, Pape UJ, Anantharaman V, Aravind L, Pursiheimo JP, Oberdoerffer S, Liu XS, Lahesmaa R, Lähdesmäki H, Rao A. Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells. Proc Natl Acad Sci U S A. 109: 16252-16257, 2012. Pubmed
Jin S, Mutvei AP, Chivukula IV, Andersson ER, Ramsköld D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling P, Mpindi JP, Kallioniemi O, Screpanti I, Poellinger L, Sahlgren C, Lendahl U. Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ. Oncogene. 2012 Nov 26. [Epub ahead of print] Pubmed
Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R. RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. Stem Cells. 2012 Mar;30(3):452-60. Pubmed
Lund RJ, Nikula T, Rahkonen N, Närvä E, Baker D, Harrison N, Andrews P, Otonkoski T, Lahesmaa R. High-throughput karyotyping of human pluripotent stem cells. Stem Cell Res. 2012 Jul 11;9(3):192-195. Pubmed
Lund RJ, Närvä E, Lahesmaa R. Genetic and epigenetic stability of human pluripotent stem cells. Nature Reviews Genetics, published online 11 September 2012; doi:10.2038/nrg3271. Pubmed

We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors and x-ray crystallography. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
Soile Tuomela, 26th of April, 2013:
System-level characterization of Th2 cell development and immune cell
responses to ZnO and TiO2 nanoparticles.
Mari Björkman, 1st of March, 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Therapeutic Development
Artur Padzik, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
Gunilla Högnäs, 8th of February, 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion
Tapio Lönnberg, 26th of October, 2012:
System-wide approaches to uncover Th2 cell lineage commitment
Elisa Närvä, 19th of October, 2012:
Pluripotency and genetic stability of human pluripotent stem cells
Krista Rantanen, 12th of October, 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
Several speakers:
The Annual BioCity Symposium: Non-coding RNAs in Biology and Medicine
Thursday, August 15 at 8:15 - Friday, August 16 at 15:30
Mauno Koivisto Centre auditorium, BioCity, Turku, Finland
Several speakers:
TuBS symposium on B cells: past, present and future
Monday, August 19 at 9:00 - Tuesday, August 20 at 15:30
PharmaCity Auditorium, Itäinen Pitkäkatu 4 B, Turku
Prof. Phoebe A. Rice:
The biochemistry and structural biology of mobile DNA
Thursday, September 5 at 12:00
Mauno Koivisto Centre auditorium, BioCity, Turku, Finland