Joint SyMMyS and FiDiPro Symposium

Wednesday, August  26th, 2015
More information.

Publications

Hot Off the Press

Fatemeh Seyednasrollah, Krista Rantanen, Panu Jaakkola and Laura L. Elo. ROTS: reproducible RNA-seq biomarker detector—prognostic markers for clear cell
renal cell cancer.  Nucl. Acids Res. August 11, 2015 Abstract

Kauko O, Laajala TD, Jumppanen M, Hintsanen P, Suni V, Haapaniemi P, Corthals G, Aittokallio T, Westermarck J, Imanishi SY. Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling. Sci Rep. 2015 Aug 17;5:13099. Pubmed

Indira V. Chivukula, Daniel Ramsköld, Helena Storvall, Charlotte Anderberg, Shaobo Jin, Veronika Mamaeva, Cecilia Sahlgren, Kristian Pietras, Rickard Sandberg and Urban Lendahl. Decoding breast cancer tissue–stroma interactions using species-specific sequencing. Breast Cancer Research 2015, 17:109 Article

Wang Y, Arjonen A, Pouwels, J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R. Formin-like 2 Promotes b1-Integrin Trafficking and Invasive Motility Downstream of PKCa. Dev. Cell. 2015. Abstract

Myant K, Qiao X, Halonen T, Come C, Laine A, Janghorban M, Partanen JI, Cassidy J, Ogg EL, Cammareri P, Laiterä T, Okkeri J, Klefström J, Sears RC, Sansom OJ, Westermarck J. Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell Rep. 2015 Jul 28. Pubmed

Jessica M. Rosenholm, Riikka M. Korpi, Eveliina Lammentausta, Siri Lehtonen, Petri Lehenkari, Rasmus Niemi, Wangchuan Xiao, Jixi Zhang, Natalie Råtts, Hongchen Gu, Cecilia Sahlgren, Roberto Blanco Sequeiros. Novel, Fast-Processed Crystalline and Amorphous Manganese Oxide Nanoparticles for Stem Cell Labeling. Inorg. Chem. Front., 2015:2 640-648. Abstract

Hussein Shokry, Ulriika Vanamo, Oliver Wiltschka,  Jenni Niinimäki, Martina Lerche,  Kalle Levon, Mika Linden and Cecilia Sahlgren. Mesoporous silica particle-PLG-PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization. Nanoscale, 2015 Advance Article. Abstract

Jaakkola MK and Elo LL. Empirical comparison of structure-based pathway methods. Briefings in bioinformatics. July 2015. PubMed

Guillaume Jacquemet, Hellyeh Hamidi, Johanna Ivaska. Filopodia in cell adhesion, 3D migration and cancer cell invasion. Current Opinion in Cell Biology 36: 23-31. Pubmed

Poudel N, Pfannstiel J, Simon O, Walter N, Papageorgiou AC, Jendrossek D. Pseudomonas aeruginosa Isohexenyl Glutaconyl-CoA Hydratase (AtuE) Is Upregulated in Citronellate-grown Cells and Belongs to the Crotonase Family. Appl Environ Microbiol. 2015. Pubmed

Marek A. Budzynski, Mikael C. Puustinen, Jenny Joutsen, and Lea Sistonen. Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation.  Mol. Cell. Biol. July 2015 35:2530-2540. Pubmed

Li L-L, Melero-Fernandez de Mera RM, Chen J, Ba W, Nadif Kasri N, Zhang M, Courtney MJ. Unexpected heterodivalent recruitment of NOS1AP to nNOS reveals multiple sites for pharmacological intervention in neuronal disease models. J Neurosci. 2015 May 13;35(19):7349-64. Pubmed

Papageorgiou AC, Li D. Expression, purification and crystallization of a family 55 β-1,3-glucanase from Chaetomium thermophilum. Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):680-683. Epub 2015 May 20. Pubmed

De Franceschi N, Ivaska J. Integrin bondage: filamin takes control. Nat Struct Mol Biol. 2015 May 6;22(5):355-7. Pubmed

Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T. CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. Oncotarget. 2015 Apr 19. [Epub ahead of print] Pubmed

Heinonen MT, Laine AP, Söderhäll C, Gruzieva O, Rautio S, Melén E, Pershagen G, Lähdesmäki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R; Finnish Pediatric Diabetes Registry. GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy. J Immunol. 2015 May 11. [Epub ahead of print] Pubmed

Pipsa Saharinen and Johanna Ivaska. Blocking integrin inactivation as an anti-angiogenic therapy. EMBO J. 2015 Mar 31. [Epub ahead of print] Pubmed

Reetta Virtakoivu, Anja Mai, Elina Mattila, Nicola De Franceschi, Susumu Y Imanishi, Garry Corthals, Riina Kaukonen, Markku Saari, Fang Cheng, Elin Torvaldson, Veli-Matti Kosma, Arto Mannermaa, Ghaffar Muharram, Christine Gilles, John Eriksson, Ylermi Soini, James B. Lorens, and Johanna Ivaska. Vimentin-ERK signaling uncouples Slug gene regulatory function. Cancer Res. 2015 Apr 8. [Epub ahead of print] Pubmed

Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports. 2015, 4:519-528. Pubmed

Suni V, Imanishi SY, Maiolica A, Aebersold R, Corthals GL. Confident site localization using a simulated phosphopeptide spectral library. J Proteome Res. 2015 Mar 16. [Epub ahead of print] Pubmed

Tiannan Guo, Petri Kouvonen, Ching Chiek Koh, Ludovic C Gillet, Witold E Wolski, Hannes L Röst, George Rosenberger, Ben C Collins, Lorenz C Blum, Silke Gillessen, Markus Joerger, Wolfram Jochum & Ruedi Aebersold. Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps. Nature Medicine (2015). Published online 02 March 2015 doi:10.1038/nm.38071. Pubmed

Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort with HLA-Conferred Susceptibility. Diabetes. 2015 Jan 23. pii: db140983. [Epub ahead of print] Pubmed

Labrou NE, Papageorgiou AC, Pavli O, Flemetakis E. Plant GSTome: structure and functional role in xenome network and plant stress response. Curr Opin Biotechnol. 2015 Jan 19;32C:186-194. Pubmed

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News

Academy of Finland supports scientific risk-taking with purpose-made funding

Turun yliopisto ja belgialainen CD3 solmivat strategisen syöpälääkkeen kehityssopimuksen

Funding from the Aof Personalized Health Programme
The Academy of Finland Center of Excellence in Molecular Systems Immunology and Physiology "SyMMyS" groups have been awarded a 2M€ grant from the Academy of Finland pHealth programme for project "Personalised medicine to predict and prevent Type 1 Diabetes" (Lahesmaa - coordinator, Oresic, Toppari, Lähdesmäki, Knip, Lahti).

Links:

http://www.aka.fi/en/research-and-science-policy/programmes/current-programmes/phealth/

http://www.utu.fi/fi/Ajankohtaista/mediatiedotteet/Sivut/kohti-sairauksien-ehkaisemista-ja-raataloityja-hoitoja.aspx

Professor Johanna Ivaska selected as EMBO member 2015
EMBO today announced that 58 outstanding researchers in the life sciences were elected to its membership. Fifty of the scientists reside in Europe and neighbouring countries; eight Associate Members were elected from China, Japan, New Zealand and the United States.

The latest scientists to join EMBO come from 19 different countries and include 18 female scientists recognized for their contributions to life science research. The EMBO Membership currently comprises more than 1700 life scientists.

Link to EMBO press release:

http://www.embo.org/news/press-releases/press-releases-2015/embo-announces-new-members-for-2015

New Ways to Shut Down Signals Involved in Brain Diseases
A research team based at the University of Eastern Finland and the Turku Centre for Biotechnology have found new ways to block a pathway that may be responsible for several brain disorders, which could open the door to developing better treatments.

Recently Awarded PhDs

Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis

Emilia Komulainen, Åbo  Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks

Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation

Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain

Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification

Tomoko Asaoka, Åbo Akademi University, 13th of December 2013: Regulation of cell fate by c-FLIP phosphorylation

Minna Kyläniemi, University of Turku, 4th of October 2013:
Regulation of lymphocyte response in vitro and in vivo

Nelly Rahkonen, University of Turku, 13th of September 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells

Saima Ferraris, Åbo Akademi University, 13th of August 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation

Anni Laine, University of Turku, 14th of June 2013, The role of an oncoprotein CIP2A in breast cancer.

Antti Arjonen, University of Turku, 14th of June 2013, Integrins on the move.

Soile Tuomela,  University of Turku, 26th of April 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.

Mari Björkman, University of Turku, 1st of March 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Therapeutic Development

Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics

Gunilla Högnäs, University of Turku, 8th of February 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion

Tapio Lönnberg, University of Turku, 26th of October 2012:
System-wide approaches to uncover Th2 cell lineage commitment

Elisa Närvä, University of Turku, 19th of October 2012:
Pluripotency and genetic stability of human pluripotent stem cells

Krista Rantanen, University of Turku, 12th of October 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival

 

Events

BTK Club

Umar Butt:
How does phosphorylation affect Sharpin function?
Tuesday, September 8 at 12:00
Turku Centre for Biotechnology seminar room, Biocity B stairs, 5th floor

Turku BioNet Seminar series about Nutrition and Health

Pentti Huovinen and Seppo Salminen:
Gut microbiota
Tuesday, September 8 at 14:30
Mauno Koivisto Centre auditorium, Biocity, Turku, Finland

MIKRO Seminars of Infection Biology and Infectious Diseases

Jukka Alinikula :
Targeting of somatic hypermutation in vertebrate genome
Wednesday, September 9 at 11:15
PharmaCity Auditorium, Itäinen Pitkäkatu 4 B, Turku

Frontiers of Science Seminar

Daniel Peeper:
Large-scale genetic in vivo perturbations to reveal novel cancer vulnerabilities
Thursday, September 10 at 12:00
Mauno Conference Center, President auditorium, Biocity, Turku

Careers

Early Stage Researcher Position

at Laura Elo's Computational Biomedicine group. Deadline for applications is October 15, 2015.

New Personnel

Mäkelä Johanna

Research Coordinator
 
Group:
Elo Laura - Computational Biomedicine

Mohammed Shahnoor

Unergraduate student
 
Group:
Sahlgren Cecilia - Cell Fate

Li Greci Lorenzo

Graduate Student
 
Group:
Courtney Michael - Neuronal Signal Pathways

Sarlin Ville-Tapani

Laboratory Technician
 
Group:
Proteomics

Islam Md Ashraful

Research Assistant