Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Hot Off the Press
Marek A. Budzynski, Mikael C. Puustinen, Jenny Joutsen, and Lea Sistonen. Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation. Mol. Cell. Biol. July 2015 35:2530-2540. Pubmed
Li L-L, Melero-Fernandez de Mera RM, Chen J, Ba W, Nadif Kasri N, Zhang M, Courtney MJ. Unexpected heterodivalent recruitment of NOS1AP to nNOS reveals multiple sites for pharmacological intervention in neuronal disease models. J Neurosci. 2015 May 13;35(19):7349-64. Pubmed
Papageorgiou AC, Li D. Expression, purification and crystallization of a family 55 β-1,3-glucanase from Chaetomium thermophilum. Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):680-683. Epub 2015 May 20. Pubmed
De Franceschi N, Ivaska J. Integrin bondage: filamin takes control. Nat Struct Mol Biol. 2015 May 6;22(5):355-7. Pubmed
Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T. CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. Oncotarget. 2015 Apr 19. [Epub ahead of print] Pubmed
Heinonen MT, Laine AP, Söderhäll C, Gruzieva O, Rautio S, Melén E, Pershagen G, Lähdesmäki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R; Finnish Pediatric Diabetes Registry. GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy. J Immunol. 2015 May 11. [Epub ahead of print] Pubmed
Pipsa Saharinen and Johanna Ivaska. Blocking integrin inactivation as an anti-angiogenic therapy. EMBO J. 2015 Mar 31. [Epub ahead of print] Pubmed
Reetta Virtakoivu, Anja Mai, Elina Mattila, Nicola De Franceschi, Susumu Y Imanishi, Garry Corthals, Riina Kaukonen, Markku Saari, Fang Cheng, Elin Torvaldson, Veli-Matti Kosma, Arto Mannermaa, Ghaffar Muharram, Christine Gilles, John Eriksson, Ylermi Soini, James B. Lorens, and Johanna Ivaska. Vimentin-ERK signaling uncouples Slug gene regulatory function. Cancer Res. 2015 Apr 8. [Epub ahead of print] Pubmed
Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports. 2015, 4:519-528. Pubmed
Suni V, Imanishi SY, Maiolica A, Aebersold R, Corthals GL. Confident site localization using a simulated phosphopeptide spectral library. J Proteome Res. 2015 Mar 16. [Epub ahead of print] Pubmed
Tiannan Guo, Petri Kouvonen, Ching Chiek Koh, Ludovic C Gillet, Witold E Wolski, Hannes L Röst, George Rosenberger, Ben C Collins, Lorenz C Blum, Silke Gillessen, Markus Joerger, Wolfram Jochum & Ruedi Aebersold. Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps. Nature Medicine (2015). Published online 02 March 2015 doi:10.1038/nm.38071. Pubmed
Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort with HLA-Conferred Susceptibility. Diabetes. 2015 Jan 23. pii: db140983. [Epub ahead of print] Pubmed
Labrou NE, Papageorgiou AC, Pavli O, Flemetakis E. Plant GSTome: structure and functional role in xenome network and plant stress response. Curr Opin Biotechnol. 2015 Jan 19;32C:186-194. Pubmed
Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM. KSHV Viral Cyclin Interferes with T-Cell Development and Induces Lymphoma through CDK6 and Notch Activation in vivo. Cell Cycle. 2014 Sep 19:0. [Epub ahead of print] Pubmed
Ventelä S, Sittig E, Mannermaa L, Mäkelä JA, Kulmala J, Löyttyniemi E, Strauss L, Cárpen O, Toppari J, Grénman R, Westermarck J. CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance. Oncotarget. 2014 Dec 1. [Epub ahead of print] Pubmed
Skopelitou K, Muleta AW, Papageorgiou AC, Chronopoulou E & Labrou NE. Catalytic features and crystal structure of a tau class glutathione transferase from Glycine max specifically upregulated in response to soybean mosaic virus infections. Biochim Biophys Acta. 2014 Dec 2. [Epub ahead of print] Pubmed
Hrdlickova B, Kumar V, Kanduri K, Zhernakova DV, Tripathi S, Karjalainen J, Lund RJ, Li Y, Ullah U, Modderman R, Abdulahad W, Lähdesmäki H, Franke L, Lahesmaa R, Wijmenga C, Withoff S. Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity. Genome Medicine. 2014, 6:88. Pubmed
Trehan A, Rotgers E, Coffey ET, Huhtaniemi I, Rivero-Müller A. CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures. Cell Commun Signal. 2014 Nov 4;12(1):70. Pubmed
Komulainen E, Zdrojewska J, Freemantle E, Mohammad H, Kulesskaya N, Deshpande P, Marchisella F, Mysore R, Hollos P, Michelsen KA, Mågard M, Rauvala H, James P, Coffey ET. JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination. Front Cell Neurosci. 2014 Sep 12;8:272. Pubmed
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
Molecular Systems Immunology groups awarded 2M€ grant
The Academy of Finland Center of Excellence in Molecular Systems Immunology and Physiology "SyMMyS" groups has been awarded a 2M€ grant from Academy of Finland pHealth programme for project "Personalised medicine to predict and prevent Type 1 Diabetes" (Lahesmaa - coordinator, Knip, Lähdesmäki, Oresic, Toppari, Lahti).
Riitta Lahesmaalle akatemiaprofessuuri
Riitta Lahesmaa aloittaa viisivuotiskautensa akatemiaprofessorina vuoden 2016 alussa. Hän tutkii T-solujen kehitystä ja toimintaa. T-solut vastaavat elimistön immuunipuolustuksesta taudinaiheuttajia ja syöpää vastaan.
Professor Johanna Ivaska selected as EMBO member 2015
EMBO today announced that 58 outstanding researchers in the life sciences were elected to its membership. Fifty of the scientists reside in Europe and neighbouring countries; eight Associate Members were elected from China, Japan, New Zealand and the United States.
The latest scientists to join EMBO come from 19 different countries and include 18 female scientists recognized for their contributions to life science research. The EMBO Membership currently comprises more than 1700 life scientists.
Link to EMBO press release:
New Ways to Shut Down Signals Involved in Brain Diseases
A research team based at the University of Eastern Finland and the Turku Centre for Biotechnology have found new ways to block a pathway that may be responsible for several brain disorders, which could open the door to developing better treatments.
Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis
Emilia Komulainen, Åbo Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks
Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation
Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain
Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification
Tomoko Asaoka, Åbo Akademi University, 13th of December 2013: Regulation of cell fate by c-FLIP phosphorylation
Minna Kyläniemi, University of Turku, 4th of October 2013:
Regulation of lymphocyte response in vitro and in vivo
Nelly Rahkonen, University of Turku, 13th of September 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells
Saima Ferraris, Åbo Akademi University, 13th of August 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation
Anni Laine, University of Turku, 14th of June 2013, The role of an oncoprotein CIP2A in breast cancer.
Antti Arjonen, University of Turku, 14th of June 2013, Integrins on the move.
Soile Tuomela, University of Turku, 26th of April 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.
Mari Björkman, University of Turku, 1st of March 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
Gunilla Högnäs, University of Turku, 8th of February 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion
Tapio Lönnberg, University of Turku, 26th of October 2012:
System-wide approaches to uncover Th2 cell lineage commitment
Elisa Närvä, University of Turku, 19th of October 2012:
Pluripotency and genetic stability of human pluripotent stem cells
Krista Rantanen, University of Turku, 12th of October 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
Bridging Nordic Imaging - Enabling discoveries from atoms to anatomy
Thursday, August 13 at 9:00 - Friday, August 14 at 16:00
Arken, Ã…bo Akademi, Fabriksgatan 2, 20500 Ã…bo
The BioCity Student Symposium - Life in science
Wednesday, August 26 at 9:00 - 16:00
PharmaCity Auditorium, ItÃ¤inen PitkÃ¤katu 4 B, Turku
25th Annual BioCity Symposium: Control and communication - Molecular law and order in biological systems
Thursday, August 27 at 8:15 - Friday, August 28 at 15:30
Mauno Conference Center, President auditorium, BioCity, Turku