Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Hot Off the Press
Guzmán C, Solman M, Abankwa D. Nanoclustering and heterogeneous membrane diffusion of Ras studied by FRAP and RICS analysis. Methods Mol Biol. 2014;1120:307-26. Pubmed
Papageorgiou AC & Mattsson J. Protein structure validation and analysis with x-ray crystallography. Methods Mol Biol. 2014; 1129:397-421. Pubmed
Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C. PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res. 2014 Mar 25 [Epub ahead of print]. Pubmed
Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol. 2014 Apr;15(4):384-92. Pubmed
Hämäläinen S, Nurminen N, Ahlfors H, Oikarinen S, Sioofy-Khojine AB, Frisk G,
Oberste MS, Lahesmaa R, Pesu M, Hyöty H. Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity. J Med Virol. 2014 Feb 20. [Epub ahead of print] Pubmed
Munukka E, Pekkala S, Wiklund P, Rasool O, Borra R, Kong L, Ojanen X, Cheng SM, Roos C, Tuomela S, Alen M, Lahesmaa R, Cheng S. Gut-adipose tissue axis in hepatic fat accumulation in humans. J Hepatol. 2014 Mar 5. pii: S0168-8278(14)00128-7. [Epub ahead of print] Pubmed
Noisa P, Lund C, Kanduri K, Lund R, Lähdesmäki H, Lahesmaa R, Lundin K,
Chokechuwattanalert H, Otonkoski T, Tuuri T, Raivio T. Notch signaling regulates neural crest differentiation from human pluripotent
stem cells. J Cell Sci. 2014 Feb 25. [Epub ahead of print] Pubmed
Kannaste O, Suomi T, Salmi J, Uusipaikka E, Nevalainen O, Corthals GL. Cross-correlation of spectral count ranking to validate quantitative proteome measurements. J Proteome Res. 2014 Mar 10. [Epub ahead of print] PubMed
Araújo JE, Oliveira EJ, Kouvonen P, Corthals GL, Lodeiro C, Santos HM, Capelo JL. A journey through PROTEOSONICS. In Press PubMed
Guzmán C, Bagga M, Kaur A, Westermarck J, Abankwa D. ColonyAreaw: An ImageJ plugin to automatically quantify colony formation in clonogenic assays. In press, PLoS One.
Guzmán C, Solman M, Ligabue A, Blazevitš O, Andrade DM, Reymond L, Eggeling C, Abankwa D. The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer specific nanoclustering. "Paper of the week". J Biol Chem. 2014 Feb 28. [Epub ahead of print] Pubmed Press Release
Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin JC, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo KR, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinun M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky JW, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF, Burgess SM, Moir SL, Gadina M, Sood R, Hershfield MS, Boehm M, Kastner DL, Aksentijevich I. Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2. N Engl J Med. 2014 Feb 19. [Epub ahead of print] Pubmed
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R. Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes. 2014 Feb 18. [Epub ahead of print] Pubmed
Zhang J, Niemelä M, Westermarck J, Rosenholm JM. Mesoporous silica nanoparticles with redox-responsive surface linkers for charge-reversible loading and release of short oligonucleotides. Dalton Trans. 2014 Jan 24. [Epub ahead of print] Pubmed
Lehtimäki S, Lahesmaa R. Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features. Front Immunol. 2013 Sep 23;4:294. Review. Pubmed
Zdrojewska, J., Coffey, E.T. The Impact of JNK on Neuronal Migration. Adv Exp Med Biol. 2014;800:37-57. Pubmed
Finn R, Ahmad T, Coffey ET, Brayden DJ, Baird AW, Boyd A. Translocation of Vibrio parahaemolyticus across an in vitro M cell model. FEMS Microbiol Lett. 2013 Nov 5. doi: 10.1111/1574-6968.12323. Pubmed
Elo LL and Schwikowski B. Analysis of Time-Resolved Gene Expression Measurements Across Individuals. PLoS ONE 8(12): e82340, 2013.
Tuomela S, Lahesmaa R.. Early T helper cell programming of gene expression in human. Semin Immunol. 2013 Nov 15;25(4):282-90. Pubmed
McDonnell LA, Walch A, Stoeckli M, Corthals GL. MSiMass List: A Public Database of Identifications for Protein MALDI MSI. J Proteome Res. 2013 Dec 6. Pubmed
Haikarainen T, Frioux C, Zhnag LQ, Li DC & Papageorgiou AC. Crystal structure and biochemical characterization of a manganese superoxide dismutase from Chaetomium thermophilum. Biochim Biophys Acta. 2013 Dec 3. Pubmed
Dominique Böcking, Oliver Wiltschka, Jenni Niinimäki, Hussein Shokry, Rolf Brenner, Mika Lindén and Cecilia Sahlgren. Mesoporous silica nanoparticle-based substrates for cell directed delivery of Notch signalling modulators to control myoblast differentiation. Nanoscale 2014 Advanced article.
Seyednasrollah F, Laiho A, Elo LL. Comparison of software packages for detecting differential expression in RNA-seq studies. Briefings in Bioinformatics 2013.
Närvä E, Pursiheimo JP, Laiho A, Rahkonen N, Emani MR, Viitala M, Laurila K, Sahla R, Lund R, Lähdesmäki H, Jaakkola P, Lahesmaa R. Continuous Hypoxic Culturing of Human embryonic Stem Cells Enhances SSEA-3 and MYC Levels. PLoS One. 2013 Nov 13;8(11):e78847. Pubmed
Sainio A, Nyman M, Lund R, Vuorikoski S, Boström P, Laato M, Boström PJ, Järveläinen H. Lack of decorin expression by human bladder cancer cells offers new tools in the therapy of urothelial malignancies. PLoS One. 2013 Oct 11;8(10):e76190. Pubmed
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors and x-ray crystallography. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
Minna Kyläniemi, University of Turku, 4th of October, 2013:
Regulation of lymphocyte response in vitro and in vivo
Nelly Rahkonen, University of Turku, 13th of September, 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells
Saima Ferraris, Åbo Akademi University, 13th of August, 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation
Soile Tuomela, University of Turku, 26th of April, 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.
Mari Björkman, University of Turku, 1st of March, 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
Gunilla Högnäs, University of Turku, 8th of February, 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion
Tapio Lönnberg, University of Turku, 26th of October, 2012:
System-wide approaches to uncover Th2 cell lineage commitment
Elisa Närvä, University of Turku, 19th of October, 2012:
Pluripotency and genetic stability of human pluripotent stem cells
Krista Rantanen, University of Turku, 12th of October, 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
Multicolour (>6) flow cytometry
Wednesday, April 23 at 14:00
Turku Center for Biotechnology seminar room, BioCity B stairs, 5th floor
Jarkko J Saarinen :
Antibacterial properties of nanoparticles
Wednesday, April 30 at 11:15
Auditorium of Microbiological Institute, Kiinamyllynkatu 13
FinnBrain minisymposium: Neurobiology of Stress and Parenting
Monday, May 5 at 12:30
Brahea, Data City (A), 2nd floor
We are searching for a talented scientist with a Ph.D diploma and strong publication track record. Extensive hands-on experience from the fields of cell / cancer biology and/or miRNA research is a must. Competences in cloning, microscopy, bio-informatics and/or translational research are highly valued.