Hot Off the Press

Guillaume Jacquemet, Habib Baghirov, Maria Georgiadou, Harri Sihto, Emilia Peuhu, Pierre Cettour-Janet, Tao He, Merja Perälä, Pauliina Kronqvist, Heikki Joensuu & Johanna Ivaska. L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nature Communications 7, Article number: 13297 (2016). Link

Suomi T, Elo LL. Accurate Detection of Differential Expression and Splicing Using Low-Level Features. Methods. Mol Biol. 2017. Pubmed

Laajala TD, Seikkula H, Seyednasrollah F, Mirtti T, Boström PJ, Elo LL. Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy. Sci Rep. Nov 2016. Pubmed

Mehrad Mahmoudian*, Fatemeh Seyednasrollah*, Liisa Koivu, Outi Hirvonen, Sirkku Jyrkkiö, Laura L. Elo. A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer. F1000Research. (*Equal contributors) Link

Perveen S, Rashid N, Papageorgiou AC. Crystal structure of a phosphoribosyl anthranilate isomerase from the hyperthermophilic archaeon Thermococcus kodakaraensis. Acta Cryst F 2016. Pubmed

Martinez-Bravo MJ, Wahlund CJ, Qazi KR, Moulder R, Lukic A, Rådmark O, Lahesmaa R, Grunewald J, Eklund A, Gabrielsson S. Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules.J Allergy Clin Immunol. 2016 Aug 23. [Epub ahead of print] Pubmed

Kaur A, Denisova O, Qiao X, Jumppanen M, Peuhu E, Ahmed SU, Raheem O, Haapasalo HK, Eriksson J, Chalmers AJ, Laakkonen PM, Westermarck J. PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Res. 2016 Sep 26. [Epub ahead of print] Pubmed

Tommi Välikangas, Tomi Suomi and Laura L. Elo. A systematic evaluation of normalization methods in quantitative label-free proteomics.  Brief Bioinform (2016)  Published online October 2, 2016. Pubmed

Lehtonen Š, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G. Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models. Antioxid Redox Signal. 2016 Sep 10;25(8):485-97. Pubmed

Axarli I, Muleta AW, Chronopoulou EG, Papageorgiou AC, Labrou NE. Directed Evolution of Glutathione Transferases Towards a Selective Glutathione-Binding Site and Improved Oxidative Stability. Biochim Biophys Acta. 2016 Sep 6.  Pubmed

Waldemarson S, Kurbasic E, Krogh M, Cifani P, Berggård T, Borg Å, James P. Proteomic analysis of breast tumors shows the mRNA intrinsic molecular subtypes with different classifiers. Breast Cancer Res. 18(1):69. Pubmed

Jaakkola MK, Seyednasrollah F, Mehmood A and Elo LL. Comparison of methods to detect differentially expressed genes between single-cell populations. Briefings in bioinformatics. July 2016 [Epub ahead of print] PubMed

Baghirov H, Karaman D, Viitala T, Duchanoy A, Lou YR, Mamaeva V, Pryazhnikov E, Khiroug L, de Lange Davies C, Sahlgren C, Rosenholm JM. Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier. PLoS One. 2016 Aug 22;11(8):e0160705 Pubmed

Siljamäki E, Abankwa D. SPRED1 interferes with K-ras but not H-ras membrane anchorage and signaling. Mol Cell Biol. 2016 Aug 8. pii: MCB.00191-16. PubMed

Posada IM, Serulla M, Zhou Y, Oetken-Lindholm C, Abankwa D, Lectez B. ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold. PLoS One. 2016 Jul 20;11(7). eCollection 2016. Pubmed

Liu C, Skaldin M, Wu C, Lu Y, Zavialov AV. Application of ADA1 as a new marker enzyme in sandwich ELISA to study the effect of adenosine on activated monocytes. Sci Rep. 2016 Aug 11; 6:31370. Pubmed

Fang Cheng, Yue Shen, Ponnuswamy Mohanasundaram, Michelle Lindström, Johanna Ivaska, Tor Ny, and John E. Eriksson. Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling. PNAS 113(30), E4320–E4327. Pubmed

Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. 2016 Aug 4;7:12237. Pubmed

Mahesh Tambe, Elli Narvi, Marko Kallio. Reduced levels of Dusp3/Vhr phosphatase impair normal spindle bipolarity in an Erk1/2 activity-dependent manner. FEBS Lett. 2016 Jul 16. Pubmed

Lundahl MJ, Cunha AG, Rojo E, Papageorgiou AC, Rautkari L, Arboleda JC, Rojas OJ. Strength and Water Interactions of Cellulose I Filaments Wet-Spun from Cellulose Nanofibril Hydrogels. Sci Rep. 2016 Jul 28;6:30695. Pubmed

Rachel Barrow-McGee, Naoki Kishi, Carine Joffre, Ludovic Ménard, Alexia Hervieu, Bakhouche A. Bakhouche, Alejandro J. Noval, Anja Mai, Camilo Guzmán, Luisa Robert-Masson, Xavier Iturrioz, James Hulit, Caroline H. Brennan, Ian R. Hart, Peter J. Parker, Johanna Ivaska & Stéphanie Kermorgant. Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nature Communications 7, Article number: 11942. Pubmed

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Some of Our Recently Awarded PhDs

Anni Vehmas, University of Turku, 2.9.2016, Tissue Proteomes: Quantitative Mass Spectrometry of Murine Liver and Ovarian Endometrioma

Jonna Alanko, University of Turku, 26th of August 2016, Integrin traffic and signalling – from plasma membrane to endosomes

Abdi Muleta, University of Turku, 26th of August 2016, Glutathione Transferases as Detoxification Agents: Structural and Functional Studies

Amanpreet Kaur, University of Turku, 19th of August 2016, The role of PME-1 in cancer: therapeutic implications

Jouko Sandholm, University of Turku, 10th of June 2016, Toll-like receptor 9 in breast cancer

Heidi Högel, University of Turku, 20th of May 2016, Life without PHD? - PHD oxygen sensor proteins in hypoxic carcinoma cell survival

Riina Kaukonen, University of Turku, 22nd of April 2016, Filopodia and stromal extracellular matrix as regulators of cancer cell invasion and growth

Hasan Mohammad, Åbo Akademi University, 6th of April, 2016: JNK regulation of neurogenesis, neuroplasticity and anxiety-related behaviors in mice

Nicola De Franceschi,  University of Turku, 12th of February 2016: Integrin cytoplasmic tail interactors: the insiders' game.  

Arafath Kaja Najumudeen, Åbo Akademi University, 15th of January 2016: Targeting oncogenic signaling proteins - new insights using a FRET-based chemical biology approach

Asta Laiho, University of Turku, 9th of January 2016: Data analysis tools and methods for DNA microarray and high-throughput sequencing data

Sini Junttila, University of Turku, 8th of January 2016: Characterisation of Cladonia rangiferina transcriptome and genome, and the effects of dehydration and rehydration on its gene expression.


Post-doctoral position in membrane traffic in cancer, application DL February 14, 2017.


Thursday, January 19 2017 at 12:00, Frontiers of Science seminar
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6 , Turku
Professor Jussi Taipale, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden:
Systems biology of cancer

Host: Jukka Westermarck

Wednesday, January 25 2017 at 11:15, MIKRO Seminars of Infection Biology and Infectious Diseases
Arje Scheinin auditorium, Dentalia, Lemminkäisenkatu 2, 2nd floor
Tero Ahola, University of Helsinki
Discovering new antivirals agaisnt alphaviruses and other RNA viruses

Host: Petri Susi

Thursday, January 26 2017 at 12:00, Frontiers of Science seminar
Presidentti auditorium, Mauno Conference Center, BioCity, Tykistökatu 6 , Turku
Dr. Marco Fritzsche, MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, UK:
Cytoskeletal actin dynamics underpin immunological synapse formation

Host: Pieta Mattila