Turku Centre for Biotechnology is a joint department of the University of Turku and Åbo Akademi University, providing high-end technologies and expertise to academic and industrial researchers. These services benefit from the internationally competitive, excellent research carried out by CBT investigators. Our researchers discover molecular events underlying biological function and identify how this information can be used to improve life quality.
Wednesday, August 26th, 2015
Hot Off the Press
Suomi T, Corthals GL, Nevalainen OS, Elo LL. Using peptide-level proteomics data for detecting differentially expressed proteins. J Proteome Res. 2015 Sep 29. Pubmed
Routila J, Mäkelä JA, Luukkaa H, Leivo I, Irjala H, Westermarck J, Mäkitie A, Ventelä S, Potential role for inhibition of protein phosphatase 2A tumor suppressor in salivary gland malignancies. Genes Chromosomes Cancer. [Epub ahead of print] Pubmed
Kaur A, Elzagheid A, Birkman EM, Avoranta T, Kytölä V, Korkeila E, Syrjänen K, Westermarck J, Sundström J. Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer. Cancer Med. 2015 Sep 17. [Epub ahead of print] Pubmed
Fatemeh Seyednasrollah, Krista Rantanen, Panu Jaakkola and Laura L. Elo. ROTS: reproducible RNA-seq biomarker detector—prognostic markers for clear cell renal cell cancer. Nucl. Acids Res. August 11, 2015 Abstract
Kauko O, Laajala TD, Jumppanen M, Hintsanen P, Suni V, Haapaniemi P, Corthals G, Aittokallio T, Westermarck J, Imanishi SY. Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling. Sci Rep. 2015 Aug 17;5:13099. Pubmed
Indira V. Chivukula, Daniel Ramsköld, Helena Storvall, Charlotte Anderberg, Shaobo Jin, Veronika Mamaeva, Cecilia Sahlgren, Kristian Pietras, Rickard Sandberg and Urban Lendahl. Decoding breast cancer tissue–stroma interactions using species-specific sequencing. Breast Cancer Research 2015, 17:109 Article
Wang Y, Arjonen A, Pouwels, J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R. Formin-like 2 Promotes b1-Integrin Trafficking and Invasive Motility Downstream of PKCa. Dev. Cell. 2015. Abstract
Myant K, Qiao X, Halonen T, Come C, Laine A, Janghorban M, Partanen JI, Cassidy J, Ogg EL, Cammareri P, Laiterä T, Okkeri J, Klefström J, Sears RC, Sansom OJ, Westermarck J. Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell Rep. 2015 Jul 28. Pubmed
Jessica M. Rosenholm, Riikka M. Korpi, Eveliina Lammentausta, Siri Lehtonen, Petri Lehenkari, Rasmus Niemi, Wangchuan Xiao, Jixi Zhang, Natalie Råtts, Hongchen Gu, Cecilia Sahlgren, Roberto Blanco Sequeiros. Novel, Fast-Processed Crystalline and Amorphous Manganese Oxide Nanoparticles for Stem Cell Labeling. Inorg. Chem. Front., 2015:2 640-648. Abstract
Hussein Shokry, Ulriika Vanamo, Oliver Wiltschka, Jenni Niinimäki, Martina Lerche, Kalle Levon, Mika Linden and Cecilia Sahlgren. Mesoporous silica particle-PLG-PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization. Nanoscale, 2015 Advance Article. Abstract
Jaakkola MK and Elo LL. Empirical comparison of structure-based pathway methods. Briefings in bioinformatics. July 2015. PubMed
Guillaume Jacquemet, Hellyeh Hamidi, Johanna Ivaska. Filopodia in cell adhesion, 3D migration and cancer cell invasion. Current Opinion in Cell Biology 36: 23-31. Pubmed
Poudel N, Pfannstiel J, Simon O, Walter N, Papageorgiou AC, Jendrossek D. Pseudomonas aeruginosa Isohexenyl Glutaconyl-CoA Hydratase (AtuE) Is Upregulated in Citronellate-grown Cells and Belongs to the Crotonase Family. Appl Environ Microbiol. 2015. Pubmed
Marek A. Budzynski, Mikael C. Puustinen, Jenny Joutsen, and Lea Sistonen. Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation. Mol. Cell. Biol. July 2015 35:2530-2540. Pubmed
Li L-L, Melero-Fernandez de Mera RM, Chen J, Ba W, Nadif Kasri N, Zhang M, Courtney MJ. Unexpected heterodivalent recruitment of NOS1AP to nNOS reveals multiple sites for pharmacological intervention in neuronal disease models. J Neurosci. 2015 May 13;35(19):7349-64. Pubmed
Papageorgiou AC, Li D. Expression, purification and crystallization of a family 55 β-1,3-glucanase from Chaetomium thermophilum. Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):680-683. Epub 2015 May 20. Pubmed
De Franceschi N, Ivaska J. Integrin bondage: filamin takes control. Nat Struct Mol Biol. 2015 May 6;22(5):355-7. Pubmed
Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T. CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. Oncotarget. 2015 Apr 19. [Epub ahead of print] Pubmed
Heinonen MT, Laine AP, Söderhäll C, Gruzieva O, Rautio S, Melén E, Pershagen G, Lähdesmäki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R; Finnish Pediatric Diabetes Registry. GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy. J Immunol. 2015 May 11. [Epub ahead of print] Pubmed
Pipsa Saharinen and Johanna Ivaska. Blocking integrin inactivation as an anti-angiogenic therapy. EMBO J. 2015 Mar 31. [Epub ahead of print] Pubmed
Reetta Virtakoivu, Anja Mai, Elina Mattila, Nicola De Franceschi, Susumu Y Imanishi, Garry Corthals, Riina Kaukonen, Markku Saari, Fang Cheng, Elin Torvaldson, Veli-Matti Kosma, Arto Mannermaa, Ghaffar Muharram, Christine Gilles, John Eriksson, Ylermi Soini, James B. Lorens, and Johanna Ivaska. Vimentin-ERK signaling uncouples Slug gene regulatory function. Cancer Res. 2015 Apr 8. [Epub ahead of print] Pubmed
Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports. 2015, 4:519-528. Pubmed
Suni V, Imanishi SY, Maiolica A, Aebersold R, Corthals GL. Confident site localization using a simulated phosphopeptide spectral library. J Proteome Res. 2015 Mar 16. [Epub ahead of print] Pubmed
Tiannan Guo, Petri Kouvonen, Ching Chiek Koh, Ludovic C Gillet, Witold E Wolski, Hannes L Röst, George Rosenberger, Ben C Collins, Lorenz C Blum, Silke Gillessen, Markus Joerger, Wolfram Jochum & Ruedi Aebersold. Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps. Nature Medicine (2015). Published online 02 March 2015 doi:10.1038/nm.38071. Pubmed
Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort with HLA-Conferred Susceptibility. Diabetes. 2015 Jan 23. pii: db140983. [Epub ahead of print] Pubmed
Labrou NE, Papageorgiou AC, Pavli O, Flemetakis E. Plant GSTome: structure and functional role in xenome network and plant stress response. Curr Opin Biotechnol. 2015 Jan 19;32C:186-194. Pubmed
We offer state-of-the-art technology platforms and expertise in the areas of genomics, proteomics and imaging as well as viral vectors, x-ray crystallography and bioinformatics. These core facilities operate within the Biocenter Finland national infrastructure network. Our user base comprises local, national and international scientists. CBT services have contributed significantly to the discovery of creative solutions to biological problems as seen from our publications.
Information on individual services can be found from the above menu. Drop by anytime to learn how CBT can advance your research in ways previously unforeseen!
Palkittu matemaattinen malli ennustaa eturauhasyövän solunsalpaajahoidon sivuvaikutuksia
Turun yliopiston ja Turun yliopistollisen keskussairaalan yhteinen tutkimusryhmä on kehittänyt syövän lääkehoidon onnistumista kuvaavan matemaattisen mallin etäispesäkkeisen eturauhassyövän hoitoon. Tutkijoiden kehittämä malli valittiin parhaiten toimivaksi malliksi Prostate Cancer DREAM 9.5 Challenge -kilpailussa, johon osallistui yhteensä yli 550 tutkijaa eri puolilta maailmaa.
Award-Winning Mathematical Model Predicts Adverse Events of Chemotherapy in Metastatic Prostate Cancer
A group of researchers from the University of Turku and Turku University Hospital has developed a predictive model to assess the efficacy of chemotherapy in patients with metastatic prostate cancer. The developed model has been selected as the top performer model in the Prostate Cancer DREAM 9.5 Challenge competition, where more than 550 researchers participated worldwide.
Funding from the Aof Personalized Health Programme
The Academy of Finland Center of Excellence in Molecular Systems Immunology and Physiology "SyMMyS" groups have been awarded a 2M€ grant from the Academy of Finland pHealth programme for project "Personalised medicine to predict and prevent Type 1 Diabetes" (Lahesmaa - coordinator, Oresic, Toppari, Lähdesmäki, Knip, Lahti).
Professor Johanna Ivaska selected as EMBO member 2015
EMBO today announced that 58 outstanding researchers in the life sciences were elected to its membership. Fifty of the scientists reside in Europe and neighbouring countries; eight Associate Members were elected from China, Japan, New Zealand and the United States.
The latest scientists to join EMBO come from 19 different countries and include 18 female scientists recognized for their contributions to life science research. The EMBO Membership currently comprises more than 1700 life scientists.
Link to EMBO press release:
Mirkka Heinonen, University of Turku, 15th of September 2015: Players of Th-cell differentiation and immune dysregulation - focus on GIMAP family genes
Jenni Mäki-Jouppila, University of Turku, 27th of March 2015: To divide or not to divide; MicroRNAs and small compounds as modulators of mitosis
Emilia Komulainen, Åbo Akademi University, 23rd of January 2015: JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks
Henna Kallionpää, University of Turku, 28th of November 2014: Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation
Justyna Zdrojewska, Åbo Akademi University, 17th of October 2014: The interplay of JNK and SCG10 during corical development and in excitotoxic responses in brain
Subhash Tripathi, University of Turku, 23rd of May 2014: Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage Specification
Tomoko Asaoka, Åbo Akademi University, 13th of December 2013: Regulation of cell fate by c-FLIP phosphorylation
Minna Kyläniemi, University of Turku, 4th of October 2013:
Regulation of lymphocyte response in vitro and in vivo
Nelly Rahkonen, University of Turku, 13th of September 2013:
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells
Saima Ferraris, Åbo Akademi University, 13th of August 2013:
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation
Anni Laine, University of Turku, 14th of June 2013, The role of an oncoprotein CIP2A in breast cancer.
Antti Arjonen, University of Turku, 14th of June 2013, Integrins on the move.
Soile Tuomela, University of Turku, 26th of April 2013:
System-level characterization of Th2 cell development and immune
cell responses to ZnO and TiO2 nanoparticles.
Mari Björkman, University of Turku, 1st of March 2013:
Identification of Epigenetic Targets in Prostate Cancer for
Artur Padzik, Åbo Akademi University, 11th of February 2013:
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
Gunilla Högnäs, University of Turku, 8th of February 2013:
Integrins in Tumorigenesis and Cancer Cell Invasion
Tapio Lönnberg, University of Turku, 26th of October 2012:
System-wide approaches to uncover Th2 cell lineage commitment
Elisa Närvä, University of Turku, 19th of October 2012:
Pluripotency and genetic stability of human pluripotent stem cells
Krista Rantanen, University of Turku, 12th of October 2012:
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
Cardiovascular molecular imaging from mouse to man
Tuesday, October 6 at 14:30
Brahea Auditorium, Data City, LemminkÃ¤isenkatu 14-18, A door, 2nd floor
Emma Haapaniemi :
Novel monogenic autoimmune diseases
Wednesday, October 7 at 11:15
PharmaCity Auditorium, ItÃ¤inen PitkÃ¤katu 4 B, Turku
Physical forces driving collective cell migration and invasion
Thursday, October 8 at 12:00
Mauno Conference Center, President auditorium, BioCity, Turku
at Laura Elo's Computational Biomedicine group. Deadline for applications is October 15, 2015.
for three years in Matej Orešič's group to study early predictive biomarkers associated with progression to type 1 diabetes. Deadline for applications is October 15, 2015.
for two years in Matej Orešič's group to study early predictive biomarkers associated with progression to type 1 diabetes. Deadline for applications is October 22, 2015.
A fixed-term (January 1st, 2016 to December 31st, 2020) position of director for Turku Centre for Biotechnology is open for applications.
to study molecular mechanisms of human T helper lymphocyte differentiation to functionally distinct subsets. Deadline for applications is October 31, 2015.
to study molecular mechanisms of Type 1 Diabetes. Deadline for applications is October 31, 2015.